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sentences

Id Subject Object Predicate Lexical cue
T1 0-77 Sentence denotes Sp1 is a critical factor for the monocytic specific expression of human CD14.
T2 78-251 Sentence denotes CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.
T3 252-374 Sentence denotes In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.
T4 375-493 Sentence denotes A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.
T5 494-650 Sentence denotes One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.
T6 651-861 Sentence denotes A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.
T7 862-957 Sentence denotes Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.
T8 958-1041 Sentence denotes The Sp1 transcription factor bound to three different regions in the CD14 promoter.
T9 1042-1302 Sentence denotes Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.
T10 1303-1600 Sentence denotes CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.
T1 0-77 Sentence denotes Sp1 is a critical factor for the monocytic specific expression of human CD14.
T2 78-251 Sentence denotes CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.
T3 252-374 Sentence denotes In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.
T4 375-493 Sentence denotes A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.
T5 494-650 Sentence denotes One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.
T6 651-861 Sentence denotes A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.
T7 862-957 Sentence denotes Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.
T8 958-1041 Sentence denotes The Sp1 transcription factor bound to three different regions in the CD14 promoter.
T9 1042-1302 Sentence denotes Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.
T10 1303-1600 Sentence denotes CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes Sp1
T2 66-76 protein denotes human CD14
T3 78-82 protein denotes CD14
T4 88-109 protein denotes membrane glycoprotein
T5 136-145 cell_type denotes monocytes
T6 150-161 cell_type denotes macrophages
T7 226-234 cell_type denotes monocyte
T8 270-279 DNA denotes CD14 gene
T9 296-311 DNA denotes human CD14 gene
T10 338-373 DNA denotes EcoRI digested chromosome 5 library
T11 377-403 DNA denotes 5.5-kilobase genomic clone
T12 430-450 DNA denotes CD14 coding sequence
T13 455-492 DNA denotes 4.2 kilobases of 5'-upstream sequence
T14 498-542 DNA denotes major and one minor transcription start site
T15 559-595 DNA denotes 101 and 130 base pairs (bp) upstream
T16 620-649 DNA denotes protein translation start ATG
T17 653-665 DNA denotes DNA fragment
T18 677-704 DNA denotes 128 bp of upstream sequence
T19 760-793 cell_line denotes CD14 positive monocytic cell line
T20 794-804 cell_line denotes Mono Mac 6
T21 824-847 cell_line denotes nonmonocytic cell lines
T22 848-852 cell_line denotes HeLa
T23 857-860 cell_line denotes REX
T24 883-895 DNA denotes DNA fragment
T25 910-926 protein denotes nuclear proteins
T26 941-956 cell_type denotes monocytic cells
T27 962-965 protein denotes Sp1
T28 966-986 protein denotes transcription factor
T29 1027-1040 DNA denotes CD14 promoter
T30 1058-1080 DNA denotes major Sp1 binding site
T31 1082-1089 DNA denotes -110 bp
T32 1215-1218 protein denotes Sp1
T33 1278-1282 protein denotes CD14
T34 1286-1301 cell_type denotes monocytic cells
T35 1303-1307 protein denotes CD14
T36 1308-1311 protein denotes Sp1
T37 1360-1379 protein denotes 105-kDa Sp1 species
T38 1427-1436 cell_type denotes monocytic
T39 1442-1461 cell_type denotes non-monocytic cells
T40 1495-1498 protein denotes Sp1
T41 1545-1548 protein denotes Sp1

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-3 NP denotes Sp1
C3 66-76 NP denotes human CD14
C2 29-76 NP denotes the monocytic specific expression of human CD14
C4 78-82 NP denotes CD14
C6 167-170 NP denotes its
C5 167-181 NP denotes its expression
C7 292-311 NP denotes the human CD14 gene
C8 651-704 NP denotes A DNA fragment containing 128 bp of upstream sequence
C9 717-752 NP denotes monocyte-specific promoter activity
C10 878-895 NP denotes this DNA fragment
C11 941-956 NP denotes monocytic cells
C12 958-986 NP denotes The Sp1 transcription factor
C13 1054-1090 NP denotes the major Sp1 binding site (-110 bp)
C14 1101-1134 NP denotes tissue-specific promoter activity
C15 1215-1218 NP denotes Sp1
C17 1278-1282 NP denotes CD14
C18 1286-1301 NP denotes monocytic cells
C16 1244-1301 NP denotes the tissue-specific expression of CD14 in monocytic cells
C19 1358-1379 NP denotes a 105-kDa Sp1 species
C20 1381-1386 NP denotes which
C21 1495-1498 NP denotes Sp1
C22 1541-1553 NP denotes the Sp1 site
C23 1563-1599 NP denotes monocytic specific promoter activity
R1 C4 C3 coref-ident CD14,human CD14
R2 C6 C4 coref-pron its,CD14
R3 C5 C2 coref-ident its expression,the monocytic specific expression of human CD14
R4 C7 C4 coref-ident the human CD14 gene,CD14
R5 C10 C8 coref-ident this DNA fragment,A DNA fragment containing 128 bp of upstream sequence
R6 C12 C1 coref-ident The Sp1 transcription factor,Sp1
R7 C14 C9 coref-ident tissue-specific promoter activity,monocyte-specific promoter activity
R8 C15 C12 coref-ident Sp1,The Sp1 transcription factor
R9 C17 C7 coref-ident CD14,the human CD14 gene
R10 C18 C11 coref-ident monocytic cells,monocytic cells
R11 C16 C2 coref-ident the tissue-specific expression of CD14 in monocytic cells,the monocytic specific expression of human CD14
R12 C20 C19 coref-relat which,a 105-kDa Sp1 species
R13 C21 C15 coref-ident Sp1,Sp1
R14 C22 C13 coref-ident the Sp1 site,the major Sp1 binding site (-110 bp)
R15 C23 C14 coref-ident monocytic specific promoter activity,tissue-specific promoter activity

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-77 Sentence denotes Sp1 is a critical factor for the monocytic specific expression of human CD14.
S2 78-251 Sentence denotes CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.
S3 252-374 Sentence denotes In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.
S4 375-493 Sentence denotes A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.
S5 494-650 Sentence denotes One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.
S6 651-861 Sentence denotes A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.
S7 862-957 Sentence denotes Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.
S8 958-1041 Sentence denotes The Sp1 transcription factor bound to three different regions in the CD14 promoter.
S9 1042-1302 Sentence denotes Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.
S10 1303-1600 Sentence denotes CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 protein_molecule denotes Sp1
T2 66-76 protein_molecule denotes human CD14
T3 78-82 protein_molecule denotes CD14
T4 88-109 protein_family_or_group denotes membrane glycoprotein
T5 136-145 cell_type denotes monocytes
T6 150-161 cell_type denotes macrophages
T7 226-234 cell_type denotes monocyte
T8 270-274 protein_molecule denotes CD14
T9 296-301 protein_molecule denotes human
T10 302-306 protein_molecule denotes CD14
T11 338-343 protein_molecule denotes EcoRI
T12 353-365 DNA_molecule denotes chromosome 5
T13 377-403 DNA_molecule denotes 5.5-kilobase genomic clone
T14 430-434 protein_molecule denotes CD14
T15 455-492 DNA_domain_or_region denotes 4.2 kilobases of 5'-upstream sequence
T16 559-595 DNA_domain_or_region denotes 101 and 130 base pairs (bp) upstream
T17 620-649 DNA_domain_or_region denotes protein translation start ATG
T18 653-665 DNA_molecule denotes DNA fragment
T19 677-704 DNA_domain_or_region denotes 128 bp of upstream sequence
T20 717-752 other_name denotes monocyte-specific promoter activity
T21 760-764 protein_molecule denotes CD14
T22 794-804 cell_line denotes Mono Mac 6
T23 824-847 cell_line denotes nonmonocytic cell lines
T24 848-852 cell_line denotes HeLa
T25 857-860 cell_line denotes REX
T26 883-895 DNA_molecule denotes DNA fragment
T27 910-926 protein_family_or_group denotes nuclear proteins
T28 941-956 cell_type denotes monocytic cells
T29 962-965 protein_molecule denotes Sp1
T30 966-986 protein_family_or_group denotes transcription factor
T31 1027-1031 protein_molecule denotes CD14
T32 1058-1063 DNA_domain_or_region denotes major
T33 1064-1067 protein_molecule denotes Sp1
T34 1082-1089 DNA_domain_or_region denotes -110 bp
T35 1169-1196 other_name denotes transactivation experiments
T36 1215-1218 protein_molecule denotes Sp1
T37 1278-1282 protein_molecule denotes CD14
T38 1286-1301 cell_type denotes monocytic cells
T39 1303-1307 protein_molecule denotes CD14
T40 1308-1311 protein_molecule denotes Sp1
T41 1360-1367 protein_molecule denotes 105-kDa
T42 1368-1371 protein_molecule denotes Sp1
T43 1427-1436 cell_type denotes monocytic
T44 1442-1461 cell_type denotes non-monocytic cells
T45 1495-1498 protein_molecule denotes Sp1
T46 1545-1548 protein_molecule denotes Sp1
T47 1563-1599 other_name denotes monocytic specific promoter activity

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 794-802 Disease denotes Mono Mac http://purl.obolibrary.org/obo/MONDO_0013607

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 66-71 OrganismTaxon denotes human 9606
T2 296-301 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 88-96 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 136-145 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T6 150-161 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 226-234 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T9 353-363 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T10 717-725 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T12 760-783 Body_part denotes CD14 positive monocytic http://purl.obolibrary.org/obo/CL_0001054
T13 1101-1107 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 1248-1254 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 33-42 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 136-145 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 150-161 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T7 226-234 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T9 717-725 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T11 760-783 Cell denotes CD14 positive monocytic http://purl.obolibrary.org/obo/CL:0001054
T12 941-950 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T14 1286-1295 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T16 1427-1436 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T18 1446-1455 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T20 1563-1572 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054