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PubMed:7512079 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1178-1181 gene:4067 denotes lyn
T1 1252-1268 disease:C0023470 denotes myeloid leukemia
R1 T0 T1 associated_with lyn,myeloid leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 108-141 cell_line denotes human myeloid leukemia cell lines
T2 206-236 cell_type denotes monocyte/macrophage-like cells
T3 255-271 protein denotes protein kinase C
T4 345-377 cell_line denotes THP-1 myeloid leukemia cell line
T5 710-715 DNA denotes c-myc
T6 734-739 DNA denotes c-myb
T7 805-826 DNA denotes beta 2-integrin genes
T8 828-833 DNA denotes CD11a
T9 838-843 DNA denotes CD11b
T10 920-952 DNA denotes src-family tyrosine kinase genes
T11 969-972 DNA denotes hck
T12 1106-1114 RNA denotes lyn mRNA
T13 1137-1142 cell_line denotes HL-60
T14 1178-1186 DNA denotes lyn gene
T15 1252-1274 cell_type denotes myeloid leukemia cells
T16 1299-1312 DNA denotes AP-1 enhancer
T17 1375-1386 cell_line denotes THP-1 cells
T18 1423-1477 DNA denotes chloramphenicol acetyl transferase (CAT)-reporter gene
T19 1505-1523 DNA denotes AP-1 binding sites
T20 1567-1570 protein denotes CAT
T21 1715-1728 DNA denotes AP-1 enhancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7512079-7#89#92#gene4067 1178-1181 gene4067 denotes lyn
7512079-7#163#179#diseaseC0023470 1252-1268 diseaseC0023470 denotes myeloid leukemia
89#92#gene4067163#179#diseaseC0023470 7512079-7#89#92#gene4067 7512079-7#163#179#diseaseC0023470 associated_with lyn,myeloid leukemia

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 73-98 NP denotes monocytic differentiation
C2 307-310 NP denotes PMA
C3 327-330 NP denotes PMA
C4 332-377 NP denotes cells of the THP-1 myeloid leukemia cell line
C5 439-467 NP denotes all-trans retinoic acid (RA)
C6 526-528 NP denotes RA
C7 563-573 NP denotes PMA and RA
C8 595-600 NP denotes genes
C9 601-606 NP denotes which
C10 640-665 NP denotes monocytic differentiation
C11 667-682 NP denotes Both RA and PMA
C12 801-826 NP denotes the beta 2-integrin genes
C13 828-843 NP denotes CD11a and CD11b
C14 899-904 NP denotes Their
C15 1026-1040 NP denotes lyn expression
C16 1089-1091 NP denotes RA
C17 1178-1197 NP denotes lyn gene expression
C18 1295-1321 NP denotes the AP-1 enhancer activity
C19 1375-1386 NP denotes THP-1 cells
C20 1540-1543 NP denotes PMA
C21 1545-1547 NP denotes RA
C22 1583-1594 NP denotes these cells
C23 1711-1737 NP denotes the AP-1 enhancer activity
R1 C3 C2 coref-ident PMA,PMA
R2 C6 C5 coref-ident RA,all-trans retinoic acid (RA)
R3 C9 C8 coref-relat which,genes
R4 C10 C1 coref-ident monocytic differentiation,monocytic differentiation
R5 C11 C7 coref-ident Both RA and PMA,PMA and RA
R6 C13 C12 coref-appos CD11a and CD11b,the beta 2-integrin genes
R7 C14 C11 coref-pron Their,Both RA and PMA
R8 C16 C6 coref-ident RA,RA
R9 C17 C15 coref-ident lyn gene expression,lyn expression
R10 C19 C4 coref-ident THP-1 cells,cells of the THP-1 myeloid leukemia cell line
R11 C20 C3 coref-ident PMA,PMA
R12 C21 C16 coref-ident RA,RA
R13 C22 C19 coref-ident these cells,THP-1 cells
R14 C23 C18 coref-ident the AP-1 enhancer activity,the AP-1 enhancer activity

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-99 Sentence denotes Comparison of retinoic acid and phorbol myristate acetate as inducers of monocytic differentiation.
S2 100-311 Sentence denotes Several human myeloid leukemia cell lines growing in vitro can be induced to differentiate to more mature monocyte/macrophage-like cells by treatment with protein kinase C-activating phorbol esters, such as PMA.
S3 312-468 Sentence denotes In addition to PMA, cells of the THP-1 myeloid leukemia cell line acquire macrophage-like characteristics after treatment with all-trans retinoic acid (RA).
S4 469-666 Sentence denotes To analyze the signal transduction mechanisms induced by RA, we first compared the effects of PMA and RA on the expression of genes which are known to be regulated during monocytic differentiation.
S5 667-786 Sentence denotes Both RA and PMA effectively down-regulated c-myc expression, while c-myb expression decreased only after PMA treatment.
S6 787-898 Sentence denotes Expression of the beta 2-integrin genes, CD11a and CD11b, was clearly increased after both of these treatments.
S7 899-1088 Sentence denotes Their effects on the src-family tyrosine kinase genes were different: hck expression was similarly induced by these agents but lyn expression was stronger and more rapid after RA treatment.
S8 1089-1275 Sentence denotes RA also enhanced lyn mRNA production rapidly in HL-60, indicating that the activation of lyn gene expression is common in monocytic and granulocytic maturation of myeloid leukemia cells.
S9 1276-1524 Sentence denotes To examine whether the AP-1 enhancer activity is involved in RA-induced monocytic differentiation, THP-1 cells were transiently transfected with a chloramphenicol acetyl transferase (CAT)-reporter gene containing 5 copies of the AP-1 binding sites.
S10 1525-1738 Sentence denotes In contrast to PMA, RA did not induce any CAT activity in these cells, thus suggesting that the RA-induced changes in the expression of those genes described above were not dependent on the AP-1 enhancer activity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-27 other_organic_compound denotes retinoic acid
T2 32-57 other_organic_compound denotes phorbol myristate acetate
T3 73-98 other_name denotes monocytic differentiation
T4 108-141 cell_line denotes human myeloid leukemia cell lines
T5 206-236 cell_type denotes monocyte/macrophage-like cells
T6 255-271 protein_molecule denotes protein kinase C
T7 283-297 other_organic_compound denotes phorbol esters
T8 307-310 other_organic_compound denotes PMA
T9 327-330 other_organic_compound denotes PMA
T10 345-377 cell_line denotes THP-1 myeloid leukemia cell line
T11 386-417 other_name denotes macrophage-like characteristics
T12 439-448 other_organic_compound denotes all-trans
T13 449-462 other_organic_compound denotes retinoic acid
T14 464-466 other_organic_compound denotes RA
T15 484-514 other_name denotes signal transduction mechanisms
T16 526-528 other_organic_compound denotes RA
T17 563-566 other_organic_compound denotes PMA
T18 571-573 other_organic_compound denotes RA
T19 640-665 other_name denotes monocytic differentiation
T20 672-674 other_organic_compound denotes RA
T21 679-682 other_organic_compound denotes PMA
T22 710-715 DNA_domain_or_region denotes c-myc
T23 734-739 DNA_domain_or_region denotes c-myb
T24 772-775 other_organic_compound denotes PMA
T25 805-826 DNA_family_or_group denotes beta 2-integrin genes
T26 828-833 DNA_domain_or_region denotes CD11a
T27 838-843 DNA_domain_or_region denotes CD11b
T28 920-952 DNA_family_or_group denotes src-family tyrosine kinase genes
T29 969-972 DNA_domain_or_region denotes hck
T30 1026-1040 other_name denotes lyn expression
T31 1075-1077 other_organic_compound denotes RA
T32 1089-1091 other_organic_compound denotes RA
T33 1106-1114 RNA_molecule denotes lyn mRNA
T34 1137-1142 cell_line denotes HL-60
T35 1178-1186 DNA_domain_or_region denotes lyn gene
T36 1252-1274 cell_type denotes myeloid leukemia cells
T37 1299-1312 DNA_domain_or_region denotes AP-1 enhancer
T38 1337-1339 other_organic_compound denotes RA
T39 1348-1373 other_name denotes monocytic differentiation
T40 1375-1386 cell_line denotes THP-1 cells
T41 1423-1457 protein_molecule denotes chloramphenicol acetyl transferase
T42 1459-1462 protein_molecule denotes CAT
T43 1505-1509 protein_molecule denotes AP-1
T44 1540-1543 other_organic_compound denotes PMA
T45 1545-1547 other_organic_compound denotes RA
T46 1567-1570 protein_molecule denotes CAT
T47 1621-1623 other_organic_compound denotes RA
T48 1715-1719 protein_molecule denotes AP-1