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sentences

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
T2 134-225 Sentence denotes FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.
T3 226-456 Sentence denotes We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).
T4 457-609 Sentence denotes By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.
T5 610-783 Sentence denotes FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.
T6 784-966 Sentence denotes In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.
T7 967-1192 Sentence denotes In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).
T8 1193-1545 Sentence denotes Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.
T9 1546-1759 Sentence denotes Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.
T1 0-133 Sentence denotes The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
T2 134-225 Sentence denotes FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.
T3 226-456 Sentence denotes We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).
T4 457-609 Sentence denotes By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.
T5 610-783 Sentence denotes FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.
T6 784-966 Sentence denotes In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.
T7 967-1192 Sentence denotes In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).
T8 1193-1545 Sentence denotes Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.
T9 1546-1759 Sentence denotes Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-45 DNA denotes interleukin-8 AP-1 and kappa B-like sites
T2 198-207 protein denotes cytokines
T3 211-224 cell_type denotes T lymphocytes
T4 283-303 protein denotes chemotactic cytokine
T5 305-318 protein denotes interleukin-8
T6 320-324 protein denotes IL-8
T7 331-348 cell_line denotes human T cell line
T8 350-362 cell_line denotes Jurkat cells
T9 496-510 DNA denotes IL-8 promoters
T10 516-543 DNA denotes AP-1 and kappa B-like sites
T11 658-662 DNA denotes AP-1
T12 666-684 DNA denotes kappa B-like sites
T13 859-868 DNA denotes AP-1 site
T14 938-947 protein denotes anti-JunD
T15 951-965 protein denotes c-Fos antibody
T16 1046-1081 protein denotes kappa B-like site binding complexes
T17 1116-1126 protein denotes antibodies
T18 1139-1164 protein denotes human Rel family proteins
T19 1166-1171 protein denotes c-Rel
T20 1173-1176 protein denotes p65
T21 1178-1181 protein denotes p50
T22 1187-1190 protein denotes p49
T23 1316-1328 DNA denotes kappa B site
T24 1332-1356 DNA denotes immunoglobulin (Ig) gene
T25 1367-1377 protein denotes NF-kappa B
T26 1436-1458 DNA denotes IL-8 kappa B-like site
T27 1466-1478 DNA denotes kappa B site
T28 1529-1544 protein denotes binding factors
T29 1594-1622 DNA denotes IL-2 NF-AT and NFIL-2A sites
T30 1630-1642 DNA denotes kappa B site
T31 1657-1661 protein denotes IL-8
T32 1662-1666 DNA denotes AP-1
T33 1671-1689 DNA denotes kappa B-like sites

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-45 NP denotes The interleukin-8 AP-1 and kappa B-like sites
C2 73-96 NP denotes FK506-sensitive pathway
C3 134-139 NP denotes FK506
C4 141-161 NP denotes an immunosuppressant
C5 243-248 NP denotes FK506
C6 281-303 NP denotes a chemotactic cytokine
C7 305-325 NP denotes interleukin-8 (IL-8)
C8 329-348 NP denotes a human T cell line
C9 350-362 NP denotes Jurkat cells
C10 377-455 NP denotes phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin)
C11 512-543 NP denotes the AP-1 and kappa B-like sites
C12 591-608 NP denotes PMA and ionomycin
C13 610-615 NP denotes FK506
C15 654-684 NP denotes the AP-1 or kappa B-like sites
C14 627-684 NP denotes the transcriptions through the AP-1 or kappa B-like sites
C16 739-744 NP denotes those
C17 813-818 NP denotes FK506
C18 872-909 NP denotes PMA/ionomycin-induced nuclear factors
C19 911-916 NP denotes which
C20 980-985 NP denotes FK506
C21 1046-1081 NP denotes kappa B-like site binding complexes
C22 1083-1088 NP denotes which
C23 1244-1249 NP denotes FK506
C24 1306-1356 NP denotes authentic kappa B site of immunoglobulin (Ig) gene
C25 1361-1366 NP denotes which
C26 1408-1413 NP denotes FK506
C27 1653-1689 NP denotes the IL-8 AP-1 and kappa B-like sites
C28 1707-1730 NP denotes FK506-sensitive pathway
R1 C4 C3 coref-appos an immunosuppressant,FK506
R2 C5 C3 coref-ident FK506,FK506
R3 C7 C6 coref-appos interleukin-8 (IL-8),a chemotactic cytokine
R4 C9 C8 coref-appos Jurkat cells,a human T cell line
R5 C11 C1 coref-ident the AP-1 and kappa B-like sites,The interleukin-8 AP-1 and kappa B-like sites
R6 C12 C10 coref-ident PMA and ionomycin,phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin)
R7 C13 C5 coref-ident FK506,FK506
R8 C15 C11 coref-ident the AP-1 or kappa B-like sites,the AP-1 and kappa B-like sites
R9 C16 C14 coref-pron those,the transcriptions through the AP-1 or kappa B-like sites
R10 C17 C13 coref-ident FK506,FK506
R11 C19 C18 coref-relat which,PMA/ionomycin-induced nuclear factors
R12 C20 C17 coref-ident FK506,FK506
R13 C22 C21 coref-relat which,kappa B-like site binding complexes
R14 C23 C20 coref-ident FK506,FK506
R15 C25 C24 coref-relat which,authentic kappa B site of immunoglobulin (Ig) gene
R16 C26 C23 coref-ident FK506,FK506
R17 C27 C15 coref-ident the IL-8 AP-1 and kappa B-like sites,the AP-1 or kappa B-like sites
R18 C28 C2 coref-ident FK506-sensitive pathway,FK506-sensitive pathway

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-133 Sentence denotes The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
S2 134-225 Sentence denotes FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.
S3 226-456 Sentence denotes We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).
S4 457-609 Sentence denotes By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.
S5 610-783 Sentence denotes FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.
S6 784-966 Sentence denotes In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.
S7 967-1192 Sentence denotes In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).
S8 1193-1545 Sentence denotes Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.
S9 1546-1759 Sentence denotes Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 73-96 other_name denotes FK506-sensitive pathway
T2 112-119 atom denotes calcium
T3 134-139 other_organic_compound denotes FK506
T4 144-161 other_name denotes immunosuppressant
T5 198-207 protein_family_or_group denotes cytokines
T6 211-224 cell_type denotes T lymphocytes
T7 243-248 other_organic_compound denotes FK506
T8 283-303 protein_family_or_group denotes chemotactic cytokine
T9 305-318 protein_molecule denotes interleukin-8
T10 320-324 protein_molecule denotes IL-8
T11 331-348 cell_line denotes human T cell line
T12 350-362 cell_line denotes Jurkat cells
T13 377-408 other_organic_compound denotes phorbol 12-myristate 13-acetate
T14 410-413 other_organic_compound denotes PMA
T15 419-426 atom denotes calcium
T16 428-432 atom denotes Ca2+
T17 445-454 other_organic_compound denotes ionomycin
T18 496-500 protein_molecule denotes IL-8
T19 516-520 DNA_domain_or_region denotes AP-1
T20 525-543 DNA_domain_or_region denotes kappa B-like sites
T21 591-594 other_organic_compound denotes PMA
T22 599-608 other_organic_compound denotes ionomycin
T23 610-615 other_organic_compound denotes FK506
T24 658-662 DNA_domain_or_region denotes AP-1
T25 666-684 DNA_domain_or_region denotes kappa B-like sites
T26 696-699 other_organic_compound denotes PMA
T27 813-818 other_organic_compound denotes FK506
T28 859-868 DNA_domain_or_region denotes AP-1 site
T29 872-875 other_organic_compound denotes PMA
T30 876-885 other_organic_compound denotes ionomycin
T31 938-947 protein_family_or_group denotes anti-JunD
T32 951-965 protein_family_or_group denotes c-Fos antibody
T33 980-985 other_organic_compound denotes FK506
T34 989-993 other_organic_compound denotes EGTA
T35 995-999 atom denotes Ca2+
T36 1046-1081 protein_complex denotes kappa B-like site binding complexes
T37 1116-1126 protein_family_or_group denotes antibodies
T38 1139-1164 protein_family_or_group denotes human Rel family proteins
T39 1166-1171 protein_molecule denotes c-Rel
T40 1173-1176 protein_molecule denotes p65
T41 1178-1181 protein_molecule denotes p50
T42 1187-1190 protein_molecule denotes p49
T43 1244-1249 other_organic_compound denotes FK506
T44 1265-1268 other_organic_compound denotes PMA
T45 1269-1278 other_organic_compound denotes ionomycin
T46 1316-1328 DNA_domain_or_region denotes kappa B site
T47 1332-1356 DNA_domain_or_region denotes immunoglobulin (Ig) gene
T48 1367-1377 protein_molecule denotes NF-kappa B
T49 1408-1413 other_organic_compound denotes FK506
T50 1436-1440 protein_molecule denotes IL-8
T51 1466-1478 DNA_domain_or_region denotes kappa B site
T52 1483-1488 other_organic_compound denotes FK506
T53 1529-1544 protein_family_or_group denotes binding factors
T54 1630-1642 DNA_domain_or_region denotes kappa B site
T55 1657-1661 protein_molecule denotes IL-8
T56 1662-1666 DNA_domain_or_region denotes AP-1
T57 1671-1689 DNA_domain_or_region denotes kappa B-like sites
T58 1707-1712 other_organic_compound denotes FK506
T59 1741-1745 atom denotes Ca2+

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 410-413 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T3 591-594 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T5 696-699 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T7 872-875 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T9 1265-1268 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 331-336 OrganismTaxon denotes human 9606
T2 1000-1008 OrganismTaxon denotes chelator 263156
T3 1139-1144 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 211-224 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T2 337-343 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 211-224 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T2 337-343 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084