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sentences

Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
T2 175-271 Sentence denotes Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
T3 272-406 Sentence denotes Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
T4 407-512 Sentence denotes Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
T5 513-728 Sentence denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
T6 729-841 Sentence denotes Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
T7 842-972 Sentence denotes There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
T8 973-1076 Sentence denotes Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
T9 1077-1162 Sentence denotes As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
T10 1163-1449 Sentence denotes Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
T11 1450-1573 Sentence denotes The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
T12 1574-1809 Sentence denotes We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
T13 1810-2007 Sentence denotes Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
T14 2008-2106 Sentence denotes These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.
T1 0-174 Sentence denotes Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
T2 175-271 Sentence denotes Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
T3 272-406 Sentence denotes Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
T4 407-512 Sentence denotes Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
T5 513-728 Sentence denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
T6 729-841 Sentence denotes Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
T7 842-972 Sentence denotes There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
T8 973-1076 Sentence denotes Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
T9 1077-1162 Sentence denotes As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
T10 1163-1449 Sentence denotes Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
T11 1450-1573 Sentence denotes The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
T12 1574-1809 Sentence denotes We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
T13 1810-2007 Sentence denotes Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
T14 2008-2106 Sentence denotes These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1989-1994 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1989-1994 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-8 protein denotes Thrombin
T2 13-30 protein denotes thrombin receptor
T3 107-110 protein denotes TCR
T4 129-133 protein denotes CD69
T5 175-183 protein denotes Thrombin
T6 203-230 cell_line denotes T leukemic cell line Jurkat
T7 300-306 protein denotes enzyme
T8 342-378 protein denotes diisopropyl fluorophosphate-thrombin
T9 432-449 protein denotes anti-thrombin III
T10 497-511 cell_line denotes Jurkat T cells
T11 525-542 protein denotes thrombin receptor
T12 621-629 protein denotes thrombin
T13 729-737 protein denotes Thrombin
T14 797-840 protein denotes molecular mass 40, 42, 70, 120, and 130 kDa
T15 879-887 protein denotes thrombin
T16 973-981 protein denotes Thrombin
T17 1019-1035 protein denotes protein kinase C
T18 1118-1126 protein denotes thrombin
T19 1141-1161 protein denotes nuclear factor NF-kB
T20 1220-1248 cell_line denotes leukemic T cell line HPB.ALL
T21 1257-1287 cell_line denotes erythroleukemic cell line K562
T22 1307-1315 protein denotes thrombin
T23 1340-1344 cell_line denotes THP1
T24 1348-1372 cell_line denotes myelomonocytic cell line
T25 1378-1382 cell_line denotes BL2,
T26 1385-1401 cell_line denotes Burkitt lymphoma
T27 1421-1429 protein denotes thrombin
T28 1471-1479 protein denotes thrombin
T29 1550-1572 RNA denotes thrombin receptor mRNA
T30 1602-1616 cell_line denotes Jurkat T cells
T31 1637-1655 protein denotes phytohemagglutinin
T32 1724-1746 RNA denotes thrombin receptor mRNA
T33 1791-1799 protein denotes thrombin
T34 1839-1847 protein denotes thrombin
T35 1865-1869 protein denotes CD69
T36 1885-1898 protein denotes interleukin 2
T37 1921-1936 protein denotes T cell receptor
T38 1959-1973 cell_line denotes Jurkat T cells
T39 1995-2006 cell_type denotes lymphocytes
T40 2045-2053 protein denotes thrombin
T41 2082-2094 cell_type denotes T lymphocyte

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-8 NP denotes Thrombin
C2 13-46 NP denotes thrombin receptor agonist peptide
C3 70-87 NP denotes T cell activation
C4 129-173 NP denotes CD69 expression and interleukin 2 production
C5 199-230 NP denotes the T leukemic cell line Jurkat
C6 263-270 NP denotes [Ca2+]i
C7 398-405 NP denotes [Ca2+]i
C8 497-511 NP denotes Jurkat T cells
C9 513-588 NP denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP)
C10 621-629 NP denotes thrombin
C11 634-654 NP denotes [Ca2+]i mobilization
C12 729-737 NP denotes Thrombin
C13 954-971 NP denotes Ca2+ mobilization
C14 973-981 NP denotes Thrombin
C15 986-989 NP denotes TRP
C16 1118-1126 NP denotes thrombin
C17 1163-1205 NP denotes Several cell lines of hematopoietic origin
C18 1307-1315 NP denotes thrombin
C19 1325-1331 NP denotes others
C20 1340-1344 NP denotes THP1
C21 1346-1372 NP denotes a myelomonocytic cell line
C22 1378-1381 NP denotes BL2
C23 1383-1401 NP denotes a Burkitt lymphoma
C24 1421-1429 NP denotes thrombin
C25 1467-1488 NP denotes the thrombin response
C26 1528-1572 NP denotes the expression of the thrombin receptor mRNA
C28 1602-1616 NP denotes Jurkat T cells
C27 1588-1616 NP denotes activation of Jurkat T cells
C29 1724-1757 NP denotes thrombin receptor mRNA expression
C30 1787-1808 NP denotes the thrombin response
C31 1839-1847 NP denotes thrombin
C32 1852-1855 NP denotes TRP
C33 1865-1909 NP denotes CD69 expression and interleukin 2 production
C34 2045-2053 NP denotes thrombin
C35 2082-2105 NP denotes T lymphocyte activation
R1 C7 C6 coref-ident [Ca2+]i,[Ca2+]i
R2 C8 C5 coref-ident Jurkat T cells,the T leukemic cell line Jurkat
R3 C9 C2 coref-ident A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP),thrombin receptor agonist peptide
R4 C10 C1 coref-ident thrombin,Thrombin
R5 C12 C10 coref-ident Thrombin,thrombin
R6 C13 C11 coref-ident Ca2+ mobilization,[Ca2+]i mobilization
R7 C14 C12 coref-ident Thrombin,Thrombin
R8 C15 C9 coref-ident TRP,A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP)
R9 C16 C14 coref-ident thrombin,Thrombin
R10 C18 C16 coref-ident thrombin,thrombin
R11 C19 C17 coref-pron others,Several cell lines of hematopoietic origin
R12 C21 C20 coref-appos a myelomonocytic cell line,THP1
R13 C23 C22 coref-appos a Burkitt lymphoma,BL2
R14 C24 C18 coref-ident thrombin,thrombin
R15 C28 C8 coref-ident Jurkat T cells,Jurkat T cells
R16 C27 C3 coref-ident activation of Jurkat T cells,T cell activation
R17 C29 C26 coref-ident thrombin receptor mRNA expression,the expression of the thrombin receptor mRNA
R18 C30 C25 coref-ident the thrombin response,the thrombin response
R19 C31 C24 coref-ident thrombin,thrombin
R20 C32 C15 coref-ident TRP,TRP
R21 C33 C4 coref-ident CD69 expression and interleukin 2 production,CD69 expression and interleukin 2 production
R22 C34 C31 coref-ident thrombin,thrombin
R23 C35 C27 coref-ident T lymphocyte activation,activation of Jurkat T cells

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-8 cui:C0040018 denotes Thrombin
E2-ti-1 13-30 cui:C0076552 denotes thrombin receptor
E3-ti-1 31-38 cui:C0243192 denotes agonist
E4-ti-1 39-46 cui:C0030956 denotes peptide
E5-ti-1 54-59 cui:C1279919 denotes early
E6-ti-1 60-66 cui:C0441471 denotes events
E7-ti-1 70-87 cui:C1155065 denotes T cell activation
E8-ti-1 107-110 cui:C0034790 denotes TCR
E9-ti-1 129-133 entrez:969 denotes CD69
E10-ti-1 134-144 cui:C0185117 denotes expression
E11-ti-1 149-162 cui:C0021756 denotes interleukin 2
E12-ti-1 163-173 cui:C0033268 denotes production
E1-ab-1 175-183 cui:C0040018 denotes Thrombin
E2-ab-1 184-195 cui:C1292856 denotes stimulation
E3-ab-1 214-223 cui:C0007600 denotes cell line
E4-ab-1 241-250 cui:C0205374 denotes transient
E5-ab-1 251-259 cui:C0442805 denotes increase
E6-ab-1 264-267 entrez:760 denotes Ca2
T1 175-195 USES denotes Thrombin stimulation
E1-ab-2 272-283 cui:C0030946 denotes Proteolytic
E2-ab-2 284-292 cui:C0439167 denotes activity
E3-ab-2 300-306 cui:C0014442 denotes enzyme
E4-ab-2 329-335 cui:C1280500 denotes effect
E5-ab-2 342-369 cui:C0022181 denotes diisopropyl fluorophosphate
E6-ab-2 370-378 cui:C0040018 denotes thrombin
E7-ab-2 399-402 entrez:760 denotes Ca2
E1-ab-3 420-427 cui:C0019573 denotes hirudin
E2-ab-3 437-445 cui:C0040018 denotes thrombin
E3-ab-3 446-449 cui:C0439070 denotes III
E4-ab-3 464-472 cui:C0040018 denotes thrombin
E5-ab-3 473-480 cui:C0205263 denotes induced
E6-ab-3 482-485 entrez:760 denotes Ca2
E7-ab-3 497-511 cui:C0376448 denotes Jurkat T cells
T2 473-480 AUGMENTS denotes induced
E1-ab-4 525-542 cui:C0076552 denotes thrombin receptor
E2-ab-4 543-550 cui:C0243192 denotes agonist
E3-ab-4 515-558 cui:C0597551 denotes synthetic thrombin receptor agonist peptide
E4-ab-4 570-578 cui:C1609982 denotes residues
E5-ab-4 608-617 cui:C1280500 denotes effective
E6-ab-4 621-629 cui:C0040018 denotes thrombin
E7-ab-4 635-638 entrez:760 denotes Ca2
E8-ab-4 642-654 cui:C0300926 denotes mobilization
E9-ab-4 665-673 cui:C0243192 denotes agonists
E10-ab-4 682-685 entrez:760 denotes Ca2
E11-ab-4 712-720 cui:C0205102 denotes internal
T3 618-620 compared_with denotes as
T4 618-620 same_as denotes as
E1-ab-5 729-737 cui:C0040018 denotes Thrombin
E2-ab-5 749-773 cui:C1519726 denotes tyrosine phosphorylation
E3-ab-5 777-784 cui:C0443302 denotes several
E4-ab-5 785-793 cui:C0033684 denotes proteins
E5-ab-5 797-811 cui:C0598892 denotes molecular mass
E6-ab-5 837-840 cui:C1532717 denotes kDa
T5 738-748 AUGMENTS denotes stimulated
E1-ab-6 854-858 cui:C0205170 denotes good
E2-ab-6 879-887 cui:C0040018 denotes thrombin
E3-ab-6 888-895 cui:C0205263 denotes induced
E4-ab-6 896-920 cui:C1519726 denotes tyrosine phosphorylation
E5-ab-6 935-940 cui:C0205449 denotes three
E6-ab-6 941-949 cui:C0033684 denotes proteins
E7-ab-6 954-957 entrez:760 denotes Ca2
E8-ab-6 959-971 cui:C0300926 denotes mobilization
E1-ab-7 973-981 cui:C0040018 denotes Thrombin
E2-ab-7 986-989 cui:C0076552 denotes TRP
E3-ab-7 986-989 cui:C0243192 denotes TRP
E4-ab-7 986-989 cui:C0030956 denotes TRP
E5-ab-7 995-1001 cui:C0015127 denotes caused
E6-ab-7 1019-1035 cui:C0033634 denotes protein kinase C
E7-ab-7 1045-1052 cui:C0010854 denotes cytosol
E8-ab-7 1060-1075 cui:C0007603 denotes plasma membrane
T6 986-989 STIMULATES denotes TRP
T7 1036-1040 LOCATION_OF denotes from
E1-ab-8 1082-1088 cui:C0332148 denotes likely
E2-ab-8 1110-1116 cui:C0441471 denotes events
E3-ab-8 1118-1126 cui:C0040018 denotes thrombin
E4-ab-8 1141-1148 cui:C0521447 denotes nuclear
E5-ab-8 1149-1155 cui:C1521761 denotes factor
E6-ab-8 1156-1161 cui:C0079904 denotes NF-kB
E1-ab-9 1163-1170 cui:C0443302 denotes Several
E2-ab-9 1171-1181 cui:C0007600 denotes cell lines
E3-ab-9 1185-1198 cui:C0018957 denotes hematopoietic
E4-ab-9 1199-1205 cui:C0439659 denotes origin
E5-ab-9 1231-1240 cui:C0007600 denotes cell line
E6-ab-9 1257-1272 cui:C0023440 denotes erythroleukemic
E7-ab-9 1273-1282 cui:C0007600 denotes cell line
E8-ab-9 1283-1287 cui:C1517631 denotes K562
E9-ab-9 1293-1303 cui:C0205342 denotes responsive
E10-ab-9 1307-1315 cui:C0040018 denotes thrombin
E11-ab-9 1325-1331 cui:C0205394 denotes others
E12-ab-9 1340-1344 entrez:2736 denotes THP1
E13-ab-9 1363-1372 cui:C0007600 denotes cell line
E14-ab-9 1378-1381 cui:C0450596 denotes BL2
E15-ab-9 1385-1401 cui:C0006413 denotes Burkitt lymphoma
E16-ab-9 1407-1417 cui:C0205269 denotes refractory
E17-ab-9 1421-1429 cui:C0040018 denotes thrombin
E18-ab-9 1433-1436 cui:C0076552 denotes TRP
E19-ab-9 1433-1436 cui:C0243192 denotes TRP
E20-ab-9 1433-1436 cui:C0030956 denotes TRP
E21-ab-9 1437-1448 cui:C1292856 denotes stimulation
T8 1433-1436 STIMULATES denotes TRP
E1-ab-10 1454-1463 cui:C0449286 denotes magnitude
E2-ab-10 1471-1479 cui:C0040018 denotes thrombin
E3-ab-10 1480-1488 cui:C0871261 denotes response
E4-ab-10 1496-1505 cui:C1547020 denotes different
E5-ab-10 1506-1516 cui:C0007634 denotes cell types
E6-ab-10 1532-1542 cui:C0185117 denotes expression
E7-ab-10 1550-1567 cui:C0076552 denotes thrombin receptor
E8-ab-10 1568-1572 cui:C0035696 denotes mRNA
E1-ab-11 1602-1616 cui:C0376448 denotes Jurkat T cells
E2-ab-11 1622-1633 cui:C0205195 denotes combination
E3-ab-11 1637-1655 cui:C0031858 denotes phytohemagglutinin
E4-ab-11 1660-1691 cui:C0039654 denotes phorbol 12-myristate 13-acetate
E5-ab-11 1701-1709 cui:C0013109 denotes dramatic
E6-ab-11 1724-1741 cui:C0076552 denotes thrombin receptor
E7-ab-11 1742-1757 cui:C1515670 denotes mRNA expression
E8-ab-11 1767-1778 cui:C1516780 denotes concomitant
E9-ab-11 1779-1783 cui:C1517945 denotes loss
E10-ab-11 1791-1799 cui:C0040018 denotes thrombin
E11-ab-11 1800-1808 cui:C0871261 denotes response
T9 1588-1598 AUGMENTS denotes activation
T10 1588-1598 AUGMENTS denotes activation
E1-ab-12 1839-1847 cui:C0040018 denotes thrombin
E2-ab-12 1852-1855 cui:C0076552 denotes TRP
E3-ab-12 1852-1855 cui:C0243192 denotes TRP
E4-ab-12 1852-1855 cui:C0030956 denotes TRP
E5-ab-12 1865-1869 entrez:969 denotes CD69
E6-ab-12 1870-1880 cui:C0185117 denotes expression
E7-ab-12 1885-1898 cui:C0021756 denotes interleukin 2
E8-ab-12 1899-1909 cui:C0033268 denotes production
E9-ab-12 1921-1936 cui:C0034790 denotes T cell receptor
E10-ab-12 1959-1973 cui:C0376448 denotes Jurkat T cells
E11-ab-12 1978-2006 cui:C1518997 denotes peripheral blood lymphocytes
T11 1856-1864 STIMULATES denotes enhanced
T12 1856-1864 STIMULATES denotes enhanced
T13 1856-1864 STIMULATES denotes enhanced
T14 1856-1864 STIMULATES denotes enhanced
T15 1910-1917 STIMULATES denotes induced
T16 1910-1917 STIMULATES denotes induced
E1-ab-13 2014-2022 cui:C0243095 denotes findings
E2-ab-13 2037-2041 cui:C0035820 denotes role
E3-ab-13 2045-2053 cui:C0040018 denotes thrombin
E4-ab-13 2059-2068 cui:C0237399 denotes potential
E5-ab-13 2084-2105 cui:C0024262 denotes lymphocyte activation
T17 2069-2078 AFFECTS denotes regulator
R1 E2-ab-1 T1 subjectOf stimulation,Thrombin stimulation
R2 E1-ab-1 T1 objectOf Thrombin,Thrombin stimulation
R3 E1-ab-3 T2 subjectOf hirudin,induced
R4 E7-ab-3 T2 objectOf Jurkat T cells,induced
R5 E3-ab-4 T3 subjectOf synthetic thrombin receptor agonist peptide,as
R6 E6-ab-4 T3 objectOf thrombin,as
R7 E3-ab-4 T4 subjectOf synthetic thrombin receptor agonist peptide,as
R8 E6-ab-4 T4 objectOf thrombin,as
R9 E1-ab-5 T5 subjectOf Thrombin,stimulated
R10 E2-ab-5 T5 objectOf tyrosine phosphorylation,stimulated
R11 E2-ab-7 T6 subjectOf TRP,TRP
R12 E6-ab-7 T6 objectOf protein kinase C,TRP
R13 E7-ab-7 T7 subjectOf cytosol,from
R14 E6-ab-7 T7 objectOf protein kinase C,from
R15 E12-ab-9 T8 subjectOf THP1,TRP
R16 E18-ab-9 T8 objectOf TRP,TRP
R17 E3-ab-11 T9 subjectOf phytohemagglutinin,activation
R18 E1-ab-11 T9 objectOf Jurkat T cells,activation
R19 E4-ab-11 T10 subjectOf phorbol 12-myristate 13-acetate,activation
R20 E1-ab-11 T10 objectOf Jurkat T cells,activation
R21 E3-ab-12 T11 subjectOf TRP,enhanced
R22 E5-ab-12 T11 objectOf CD69,enhanced
R23 E3-ab-12 T12 subjectOf TRP,enhanced
R24 E7-ab-12 T12 objectOf interleukin 2,enhanced
R25 E1-ab-12 T13 subjectOf thrombin,enhanced
R26 E5-ab-12 T13 objectOf CD69,enhanced
R27 E1-ab-12 T14 subjectOf thrombin,enhanced
R28 E7-ab-12 T14 objectOf interleukin 2,enhanced
R29 E9-ab-12 T15 subjectOf T cell receptor,induced
R30 E7-ab-12 T15 objectOf interleukin 2,induced
R31 E9-ab-12 T16 subjectOf T cell receptor,induced
R32 E5-ab-12 T16 objectOf CD69,induced
R33 E3-ab-13 T17 subjectOf thrombin,regulator
R34 E5-ab-13 T17 objectOf lymphocyte activation,regulator

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-174 Sentence denotes Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
S2 175-271 Sentence denotes Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
S3 272-406 Sentence denotes Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
S4 407-512 Sentence denotes Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
S5 513-728 Sentence denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
S6 729-841 Sentence denotes Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
S7 842-972 Sentence denotes There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
S8 973-1076 Sentence denotes Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
S9 1077-1162 Sentence denotes As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
S10 1163-1449 Sentence denotes Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
S11 1450-1573 Sentence denotes The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
S12 1574-1809 Sentence denotes We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
S13 1810-2007 Sentence denotes Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
S14 2008-2106 Sentence denotes These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-8 protein_molecule denotes Thrombin
T2 13-30 protein_family_or_group denotes thrombin receptor
T3 70-87 other_name denotes T cell activation
T4 107-110 protein_family_or_group denotes TCR
T5 129-133 protein_molecule denotes CD69
T6 175-183 protein_molecule denotes Thrombin
T7 203-230 cell_line denotes T leukemic cell line Jurkat
T8 241-259 other_name denotes transient increase
T9 263-264 other_name denotes [
T10 264-268 atom denotes Ca2+
T11 272-292 other_name denotes Proteolytic activity
T12 300-306 protein_family_or_group denotes enzyme
T13 342-378 protein_molecule denotes diisopropyl fluorophosphate-thrombin
T14 398-399 other_name denotes [
T15 399-403 atom denotes Ca2+
T16 420-427 peptide denotes hirudin
T17 432-449 protein_family_or_group denotes anti-thrombin III
T18 464-480 other_name denotes thrombin-induced
T19 481-482 other_name denotes [
T20 482-486 atom denotes Ca2+
T21 497-511 cell_line denotes Jurkat T cells
T22 525-542 protein_family_or_group denotes thrombin receptor
T23 560-563 peptide denotes TRP
T24 568-578 peptide denotes 7 residues
T25 580-587 peptide denotes SFLLRNP
T26 621-629 protein_molecule denotes thrombin
T27 634-635 other_name denotes [
T28 635-639 atom denotes Ca2+
T29 682-686 atom denotes Ca2+
T30 712-727 cell_component denotes internal stores
T31 729-737 protein_molecule denotes Thrombin
T32 749-757 amino_acid_monomer denotes tyrosine
T33 879-887 protein_molecule denotes thrombin
T34 896-904 amino_acid_monomer denotes tyrosine
T35 954-958 atom denotes Ca2+
T36 973-981 protein_molecule denotes Thrombin
T37 986-989 peptide denotes TRP
T38 1019-1035 protein_molecule denotes protein kinase C
T39 1045-1052 cell_component denotes cytosol
T40 1060-1075 cell_component denotes plasma membrane
T41 1118-1126 protein_molecule denotes thrombin
T42 1141-1161 protein_molecule denotes nuclear factor NF-kB
T43 1220-1248 cell_line denotes leukemic T cell line HPB.ALL
T44 1257-1287 cell_line denotes erythroleukemic cell line K562
T45 1307-1315 protein_molecule denotes thrombin
T46 1340-1344 cell_line denotes THP1
T47 1348-1372 cell_line denotes myelomonocytic cell line
T48 1378-1382 cell_line denotes BL2,
T49 1385-1401 cell_line denotes Burkitt lymphoma
T50 1421-1429 protein_molecule denotes thrombin
T51 1433-1436 peptide denotes TRP
T52 1471-1479 protein_molecule denotes thrombin
T53 1550-1558 protein_molecule denotes thrombin
T54 1602-1616 cell_line denotes Jurkat T cells
T55 1637-1655 protein_molecule denotes phytohemagglutinin
T56 1660-1691 other_organic_compound denotes phorbol 12-myristate 13-acetate
T57 1724-1732 protein_molecule denotes thrombin
T58 1791-1799 protein_molecule denotes thrombin
T59 1839-1847 protein_molecule denotes thrombin
T60 1852-1855 peptide denotes TRP
T61 1865-1869 protein_molecule denotes CD69
T62 1885-1898 protein_molecule denotes interleukin 2
T63 1921-1936 protein_family_or_group denotes T cell receptor
T64 1959-1973 cell_line denotes Jurkat T cells
T65 1995-2006 cell_type denotes lymphocytes
T66 2045-2053 protein_molecule denotes thrombin
T67 2082-2094 cell_type denotes T lymphocyte

metamap-sample

Id Subject Object Predicate Lexical cue
T1 1922-1937 C0034790 denotes cell receptor
T2 108-111 C0034790 denotes CR
T3 2046-2054 C0040018 denotes hrombin
T4 1840-1848 C0040018 denotes hrombin
T5 1472-1480 C0040018 denotes hrombin
T6 1119-1127 C0040018 denotes hrombin
T7 987-990 C0040018 denotes RP
T8 974-982 C0040018 denotes hrombin
T9 880-888 C0040018 denotes hrombin-
T10 730-738 C0040018 denotes hrombin
T11 622-630 C0040018 denotes hrombin
T12 371-379 C0040018 denotes hrombin
T13 176-184 C0040018 denotes hrombin
T14 1-9 C0040018 denotes hrombin
T15 1853-1856 C0668084 denotes RP
T16 1725-1742 C0668084 denotes hrombin receptor
T17 1551-1568 C0668084 denotes hrombin receptor
T18 1434-1437 C0668084 denotes RP
T19 526-543 C0668084 denotes hrombin receptor
T20 14-31 C0668084 denotes hrombin receptor
T21 1853-1856 C0030956 denotes RP
T22 1434-1437 C0030956 denotes RP
T23 987-990 C0030956 denotes RP
T24 40-47 C0030956 denotes eptide
T25 150-174 C1819447 denotes nterleukin 2 production.
T26 1111-1117 C0441471 denotes vents,
T27 61-67 C0441471 denotes vents
T28 1911-1918 C0205263 denotes nduced
T29 889-896 C0205263 denotes nduced
T30 675-682 C0205263 denotes nduced
T31 474-481 C0205263 denotes nduced
T32 232-239 C0205263 denotes nduced
T33 48-54 C0205263 denotes nduce
T34 2083-2106 C1155065 denotes lymphocyte activation.
T35 1871-1881 C0185117 denotes xpression
T36 135-145 C0185117 denotes xpression
T37 1938-1951 C0332220 denotes ross-linking
T38 112-125 C0332220 denotes ross-linking
T39 1866-1870 C3540471 denotes D69
T40 130-134 C3540471 denotes D69
T41 1853-1856 C2987634 denotes RP
T42 1434-1437 C2987634 denotes RP
T43 987-990 C2987634 denotes RP
T44 544-551 C2987634 denotes gonist
T45 32-39 C2987634 denotes gonist
T46 55-60 C1279919 denotes arly
T47 1967-1974 C0039194 denotes cells
T48 505-512 C0039194 denotes cells.
T49 1172-1182 C0007600 denotes ell lines
T50 1386-1402 C0006413 denotes urkitt lymphoma
T51 955-958 C0596235 denotes a2+
T52 483-486 C0596235 denotes a2+
T53 400-403 C0596235 denotes a2+
T54 265-268 C0596235 denotes a2+
T55 421-428 C0019573 denotes irudin
T56 1258-1273 C0023440 denotes rythroleukemic
T57 1046-1053 C1383501 denotes ytosol
T58 1638-1656 C0031858 denotes hytohemagglutinin
T59 1003-1016 C0040715 denotes ranslocation
T60 343-370 C0022181 denotes iisopropyl fluorophosphate-
T61 641-641 C0221138 denotes
T62 488-488 C0221138 denotes
T63 405-406 C0221138 denotes .
T64 270-271 C0221138 denotes .
T65 581-588 C0252816 denotes FLLRNP)
T66 1157-1162 C0079904 denotes F-kB.
T67 1061-1076 C0007603 denotes lasma membrane.
T68 666-674 C0243192 denotes gonists
T69 1578-1583 C0150312 denotes ound
T70 594-599 C0150312 denotes ound
T71 600-602 C1883351 denotes o
T72 387-389 C1883351 denotes o
T73 960-972 C0185112 denotes obilization.
T74 643-655 C0185112 denotes obilization,
T75 390-398 C0442805 denotes ncrease
T76 252-260 C0442805 denotes ncrease
T77 273-284 C1947941 denotes roteolytic
T78 1438-1449 C1292856 denotes timulation.
T79 185-196 C1292856 denotes timulation
T80 897-921 C1519726 denotes yrosine phosphorylation
T81 750-774 C1519726 denotes yrosine phosphorylation
T82 1801-1809 C0871261 denotes esponse.
T83 1481-1489 C0871261 denotes esponse
T84 1186-1199 C0018957 denotes ematopoietic
T85 786-794 C0033684 denotes roteins
T86 1128-1137 C1879547 denotes ctivated
T87 1379-1382 C1416373 denotes L2,
T88 1857-1865 C2349975 denotes nhanced
T89 380-386 C0231175 denotes ailed
T90 1207-1216 C0332257 denotes ncluding
T91 451-460 C0311403 denotes nhibited
T92 739-749 C1948023 denotes timulated
T93 1623-1634 C1947911 denotes ombination
T94 2015-2023 C2607943 denotes indings
T95 1518-1528 C2348042 denotes aralleled
T96 1979-2007 C1518997 denotes eripheral blood lymphocytes.
T97 1090-1101 C0686907 denotes onsequence
T98 838-841 C1532717 denotes Da.
T99 2070-2079 C1704735 denotes egulator
T100 447-450 C0439070 denotes II
T101 1284-1288 C1517631 denotes 562
T102 609-618 C1280519 denotes ffective
T103 603-605 C2987476 denotes e
T104 1294-1304 C0205342 denotes esponsive
T105 1408-1418 C0205269 denotes efractory
T106 330-336 C1280500 denotes ffect
T107 2038-2042 C1705810 denotes ole
T108 1326-1332 C1955473 denotes thers
T109 312-320 C1514873 denotes equired
T110 285-293 C0441655 denotes ctivity
T111 688-695 C0439180 denotes elease
T112 1177-1182 C0205132 denotes ines
T113 1455-1464 C1704240 denotes agnitude
T114 1759-1762 C1515981 denotes nd
T115 1780-1784 C1517945 denotes oss
T116 1768-1779 C0521115 denotes oncomitant
T117 1693-1696 C1708698 denotes ed
T118 1711-1721 C0021469 denotes nhibition
T119 860-871 C1707520 denotes orrelation
T120 2060-2069 C3245505 denotes otential
T121 1083-1089 C0750492 denotes ikely
T122 1497-1506 C1705242 denotes ifferent
T123 1150-1156 C1521761 denotes actor
T124 1142-1149 C0521447 denotes uclear
T125 242-250 C0205374 denotes ransient
T126 1341-1345 C0812306 denotes HP1,
T127 206-219 C1517806 denotes eukemic cell
T128 798-812 C3152252 denotes olecular mass
T129 1200-1206 C0439659 denotes rigin
T130 713-720 C0205102 denotes nternal
T131 1164-1171 C0439064 denotes everal
T132 813-815 C0439509 denotes 0,
T133 220-224 C1550648 denotes ine
T134 855-859 C0205170 denotes ood
T135 936-941 C0205449 denotes hree
T136 722-728 C1698986 denotes tores.
T137 571-579 C1882936 denotes esidues
T138 996-1002 C1524003 denotes aused

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1385-1401 Disease denotes Burkitt lymphoma http://purl.obolibrary.org/obo/MONDO_0007243

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1989-1994 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1385-1401 Phenotype denotes Burkitt lymphoma HP:0030080

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
T2 175-271 Sentence denotes Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
T3 272-406 Sentence denotes Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
T4 407-512 Sentence denotes Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
T5 513-728 Sentence denotes A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
T6 729-841 Sentence denotes Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
T7 842-972 Sentence denotes There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
T8 973-1076 Sentence denotes Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
T9 1077-1162 Sentence denotes As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
T10 1163-1449 Sentence denotes Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
T11 1450-1573 Sentence denotes The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
T12 1574-1809 Sentence denotes We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
T13 1810-2007 Sentence denotes Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
T14 2008-2106 Sentence denotes These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 70-76 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T2 1045-1052 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T3 1060-1075 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T4 1229-1235 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T5 1921-1927 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T6 1989-2006 Body_part denotes blood lymphocytes http://purl.obolibrary.org/obo/CL_4030029
T7 2082-2094 Body_part denotes T lymphocyte http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 70-76 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 504-511 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 1229-1235 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 1609-1616 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 1921-1927 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T6 1966-1973 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T7 1978-2006 Cell denotes peripheral blood lymphocytes http://purl.obolibrary.org/obo/CL:4030030
T8 2082-2094 Cell denotes T lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T9 2084-2094 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542