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PubMed:7509852 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-99 Sentence denotes Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.
TextSentencer_T2 100-108 Sentence denotes PURPOSE:
TextSentencer_T3 109-255 Sentence denotes Detection of occult carcinoma in patients with breast cancer may aid the establishment of prognosis and development of new therapeutic approaches.
TextSentencer_T4 256-524 Sentence denotes To improve on existing methods of detection, we have developed a reverse-transcriptase polymerase chain reaction (RT-PCR) assay for keratin 19 (K19) transcripts to identify mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
TextSentencer_T5 525-546 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T6 547-741 Sentence denotes Peripheral-blood or bone marrow samples obtained from 34 patients with stages I to IV breast cancer and 39 control subjects without breast cancer were screened for K19 mRNA by nested primer PCR.
TextSentencer_T7 742-750 Sentence denotes RESULTS:
TextSentencer_T8 751-900 Sentence denotes In reconstitution experiments, K19 RT-PCR reliably detected 10 mammary carcinoma cells in 1 million normal peripheral-blood mononuclear (PBMN) cells.
TextSentencer_T9 901-999 Sentence denotes Four of 19 patients with stage IV breast cancer had detectable K19 transcript in peripheral blood.
TextSentencer_T10 1000-1185 Sentence denotes Five of six patients with histologically negative bone marrow biopsies following preablative chemotherapy and before autologous bone marrow transplant (BMT) were positive by this assay.
TextSentencer_T11 1186-1326 Sentence denotes Stem-cell apheresis harvests obtained from one of these patients and three additional patients immediately before BMT were all K19-negative.
TextSentencer_T12 1327-1437 Sentence denotes K19 RT-PCR analysis of CSF from a breast cancer patient with known carcinomatous meningitis was also positive.
TextSentencer_T13 1438-1515 Sentence denotes Thirty-eight of 39 non-breast cancer patients had negative K19 RT-PCR assays.
TextSentencer_T14 1516-1582 Sentence denotes The one exception was a patient with chronic myelogenous leukemia.
TextSentencer_T15 1583-1771 Sentence denotes CONCLUSION: RT-PCR of K19 is a sensitive, specific, and rapid method for detection of occult mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
TextSentencer_T16 1772-1926 Sentence denotes The presence of residual breast cancer cells in histologically normal bone marrow aspirates but not in stem-cell apheresis harvests is a frequent finding.
TextSentencer_T17 1927-2049 Sentence denotes This assay may be useful in diagnosing metastatic disease, as well as in monitoring the effectiveness of systemic therapy.
T1 0-99 Sentence denotes Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.
T2 100-108 Sentence denotes PURPOSE:
T3 109-255 Sentence denotes Detection of occult carcinoma in patients with breast cancer may aid the establishment of prognosis and development of new therapeutic approaches.
T4 256-524 Sentence denotes To improve on existing methods of detection, we have developed a reverse-transcriptase polymerase chain reaction (RT-PCR) assay for keratin 19 (K19) transcripts to identify mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
T5 525-546 Sentence denotes PATIENTS AND METHODS:
T6 547-741 Sentence denotes Peripheral-blood or bone marrow samples obtained from 34 patients with stages I to IV breast cancer and 39 control subjects without breast cancer were screened for K19 mRNA by nested primer PCR.
T7 742-750 Sentence denotes RESULTS:
T8 751-900 Sentence denotes In reconstitution experiments, K19 RT-PCR reliably detected 10 mammary carcinoma cells in 1 million normal peripheral-blood mononuclear (PBMN) cells.
T9 901-999 Sentence denotes Four of 19 patients with stage IV breast cancer had detectable K19 transcript in peripheral blood.
T10 1000-1185 Sentence denotes Five of six patients with histologically negative bone marrow biopsies following preablative chemotherapy and before autologous bone marrow transplant (BMT) were positive by this assay.
T11 1186-1326 Sentence denotes Stem-cell apheresis harvests obtained from one of these patients and three additional patients immediately before BMT were all K19-negative.
T12 1327-1437 Sentence denotes K19 RT-PCR analysis of CSF from a breast cancer patient with known carcinomatous meningitis was also positive.
T13 1438-1515 Sentence denotes Thirty-eight of 39 non-breast cancer patients had negative K19 RT-PCR assays.
T14 1516-1582 Sentence denotes The one exception was a patient with chronic myelogenous leukemia.
T15 1583-1771 Sentence denotes CONCLUSION: RT-PCR of K19 is a sensitive, specific, and rapid method for detection of occult mammary carcinoma cells in the peripheral blood and bone marrow of patients with breast cancer.
T16 1772-1926 Sentence denotes The presence of residual breast cancer cells in histologically normal bone marrow aspirates but not in stem-cell apheresis harvests is a frequent finding.
T17 1927-2049 Sentence denotes This assay may be useful in diagnosing metastatic disease, as well as in monitoring the effectiveness of systemic therapy.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 388-398 gene:3880 denotes keratin 19
T1 429-446 disease:C0678222 denotes mammary carcinoma
T2 388-398 gene:3880 denotes keratin 19
T3 510-523 disease:C0006142 denotes breast cancer
T4 388-398 gene:3880 denotes keratin 19
T5 510-523 disease:C0678222 denotes breast cancer
T6 400-403 gene:3880 denotes K19
T7 429-446 disease:C0678222 denotes mammary carcinoma
T8 400-403 gene:3880 denotes K19
T9 510-523 disease:C0006142 denotes breast cancer
T10 400-403 gene:3880 denotes K19
T11 510-523 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with keratin 19,mammary carcinoma
R2 T2 T3 associated_with keratin 19,breast cancer
R3 T4 T5 associated_with keratin 19,breast cancer
R4 T6 T7 associated_with K19,mammary carcinoma
R5 T8 T9 associated_with K19,breast cancer
R6 T10 T11 associated_with K19,breast cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7509852-11#10#13#gene3880 1605-1608 gene3880 denotes K19
7509852-11#81#98#diseaseC0678222 1676-1693 diseaseC0678222 denotes mammary carcinoma
7509852-5#63#66#gene3880 964-967 gene3880 denotes K19
7509852-5#25#47#diseaseC0278488 926-948 diseaseC0278488 denotes stage IV breast cancer
10#13#gene388081#98#diseaseC0678222 7509852-11#10#13#gene3880 7509852-11#81#98#diseaseC0678222 associated_with K19,mammary carcinoma
63#66#gene388025#47#diseaseC0278488 7509852-5#63#66#gene3880 7509852-5#25#47#diseaseC0278488 associated_with K19,stage IV breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2255 1350-1353 gene:1437 denotes CSF
T2256 1361-1374 disease:C0006142 denotes breast cancer
T2257 1394-1418 disease:C0220654 denotes carcinomatous meningitis
R1 T2255 T2256 associated_with CSF,breast cancer
R2 T2255 T2256 associated_with CSF,breast cancer
R3 T2255 T2256 associated_with CSF,breast cancer
R4 T2255 T2256 associated_with CSF,breast cancer
R5 T2255 T2257 associated_with CSF,carcinomatous meningitis
R6 T2255 T2257 associated_with CSF,carcinomatous meningitis
R7 T2255 T2257 associated_with CSF,carcinomatous meningitis
R8 T2255 T2257 associated_with CSF,carcinomatous meningitis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 30-36 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 156-162 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 510-516 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 633-639 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 679-685 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 935-941 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1361-1367 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1461-1467 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1757-1763 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 1797-1803 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T11 471-476 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T12 558-563 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T13 869-874 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T14 993-998 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T15 1718-1723 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T16 481-492 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T17 567-578 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T18 1050-1061 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T19 1128-1139 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T20 1728-1739 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T21 1842-1853 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 471-476 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 558-563 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T3 869-874 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T4 993-998 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T5 1718-1723 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T6 30-36 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 156-162 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 510-516 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 633-639 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 679-685 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T11 935-941 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T12 1361-1367 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T13 1461-1467 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T14 1757-1763 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T15 1797-1803 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T16 481-492 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T17 567-578 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T18 1050-1061 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T19 1128-1139 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T20 1728-1739 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T21 1842-1853 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow