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PubMed:7500028 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1513-1518 gene:6772 denotes Stat1
T1 1638-1647 disease:C0039103 denotes synovitis
T2 1523-1528 gene:6774 denotes Stat3
T3 1638-1647 disease:C0039103 denotes synovitis
R1 T0 T1 associated_with Stat1,synovitis
R2 T2 T3 associated_with Stat3,synovitis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 29-37 protein denotes cytokine
T2 107-111 protein denotes STAT
T3 146-155 protein denotes cytokines
T4 346-354 protein denotes cytokine
T5 423-432 protein denotes cytokines
T6 442-520 protein denotes signal transducer and activation of transcription (STAT) transcription factors
T7 601-634 cell_line denotes mononuclear cell priming cultures
T8 639-667 cell_type denotes inflammatory synovial fluids
T9 669-672 cell_type denotes SFs
T10 735-743 protein denotes cytokine
T11 759-763 protein denotes STAT
T12 831-834 cell_type denotes SFs
T13 883-905 protein denotes interferon (IFN)-gamma
T14 915-933 protein denotes interleukin (IL) 4
T15 949-963 cell_type denotes effector cells
T16 1026-1030 protein denotes IL-4
T17 1035-1040 protein denotes IL-10
T18 1059-1064 protein denotes IL-12
T19 1139-1142 cell_type denotes SFs
T20 1177-1203 protein denotes transcription factor Stat1
T21 1213-1218 protein denotes Stat3
T22 1251-1256 protein denotes Stat1
T23 1298-1307 protein denotes cytokines
T24 1366-1375 protein denotes IFN-gamma
T25 1395-1400 protein denotes Stat3
T26 1410-1415 protein denotes Stat1
T27 1575-1581 cell_type denotes T cell

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7500028-8#52#57#gene6772 1513-1518 gene6772 denotes Stat1
7500028-8#62#67#gene6774 1523-1528 gene6774 denotes Stat3
7500028-8#177#186#diseaseC0039103 1638-1647 diseaseC0039103 denotes synovitis
52#57#gene6772177#186#diseaseC0039103 7500028-8#52#57#gene6772 7500028-8#177#186#diseaseC0039103 associated_with Stat1,synovitis
62#67#gene6774177#186#diseaseC0039103 7500028-8#62#67#gene6774 7500028-8#177#186#diseaseC0039103 associated_with Stat3,synovitis

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 29-48 NP denotes cytokine production
C2 53-142 NP denotes the signal transducer and activator of transcription (STAT) transcription factor activity
C3 146-155 NP denotes cytokines
C4 160-188 NP denotes inflammatory synovial fluids
C5 210-256 NP denotes type 1 and 2 T helper cell cytokine production
C6 442-520 NP denotes signal transducer and activation of transcription (STAT) transcription factors
C7 522-527 NP denotes which
C8 639-673 NP denotes inflammatory synovial fluids (SFs)
C9 735-754 NP denotes cytokine production
C10 759-772 NP denotes STAT activity
C11 831-834 NP denotes SFs
C12 883-945 NP denotes interferon (IFN)-gamma, but not interleukin (IL) 4, production
C13 995-1009 NP denotes SF suppression
C14 1081-1083 NP denotes it
C15 1139-1142 NP denotes SFs
C17 1177-1203 NP denotes transcription factor Stat1
C16 1165-1218 NP denotes activity of transcription factor Stat1, but not Stat3
C18 1251-1265 NP denotes Stat1 activity
C19 1298-1307 NP denotes cytokines
C20 1325-1330 NP denotes their
C21 1366-1386 NP denotes IFN-gamma production
C22 1410-1415 NP denotes Stat1
R1 C5 C1 coref-ident type 1 and 2 T helper cell cytokine production,cytokine production
R2 C7 C6 coref-relat which,signal transducer and activation of transcription (STAT) transcription factors
R3 C8 C4 coref-ident inflammatory synovial fluids (SFs),inflammatory synovial fluids
R4 C9 C1 coref-ident cytokine production,cytokine production
R5 C10 C2 coref-ident STAT activity,the signal transducer and activator of transcription (STAT) transcription factor activity
R6 C11 C8 coref-ident SFs,inflammatory synovial fluids (SFs)
R7 C14 C13 coref-pron it,SF suppression
R8 C15 C11 coref-ident SFs,SFs
R9 C18 C16 coref-ident Stat1 activity,"activity of transcription factor Stat1, but not Stat3"
R10 C19 C3 coref-ident cytokines,cytokines
R11 C20 C19 coref-pron their,cytokines
R12 C21 C12 coref-ident IFN-gamma production,"interferon (IFN)-gamma, but not interleukin (IL) 4, production"
R13 C22 C17 coref-ident Stat1,transcription factor Stat1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-189 Sentence denotes Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids.
S2 190-417 Sentence denotes The balance between type 1 and 2 T helper cell cytokine production plays an important role in several animal models of autoimmunity, and skewed patterns of cytokine expression have been described in human inflammatory diseases.
S3 418-592 Sentence denotes Many cytokines activate signal transducer and activation of transcription (STAT) transcription factors, which, in turn, activate transcription of inflammatory effector genes.
S4 593-818 Sentence denotes We used mononuclear cell priming cultures and inflammatory synovial fluids (SFs) derived from arthritis patients to examine the regulation of cytokine production and STAT activity by an inflammatory synovial microenvironment.
S5 819-994 Sentence denotes Exposure to SFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma, but not interleukin (IL) 4, production by effector cells generated in priming cultures.
S6 995-1138 Sentence denotes SF suppression was mediated by IL-4 and IL-10 and inhibition of IL-12 expression, and it was reversed in a dominant fashion by exogenous IL-12.
S7 1139-1387 Sentence denotes SFs blocked the sustained activity of transcription factor Stat1, but not Stat3, during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production.
S8 1388-1460 Sentence denotes Active Stat3, but not Stat1, was detected in cells from inflamed joints.
S9 1461-1648 Sentence denotes These results suggest a role for altered balance of Stat1 and Stat3 transcriptional activity in the regulation of T cell differentiation and in the pathogenesis of inflammatory synovitis.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 29-37 protein_family_or_group denotes cytokine
T2 57-107 other_name denotes signal transducer and activator of transcription (
T3 107-111 protein_family_or_group denotes STAT
T4 146-155 protein_family_or_group denotes cytokines
T5 346-354 protein_family_or_group denotes cytokine
T6 389-416 other_name denotes human inflammatory diseases
T7 423-432 protein_family_or_group denotes cytokines
T8 442-493 protein_family_or_group denotes signal transducer and activation of transcription (
T9 493-497 protein_family_or_group denotes STAT
T10 601-634 cell_line denotes mononuclear cell priming cultures
T11 639-667 cell_type denotes inflammatory synovial fluids
T12 669-672 cell_type denotes SFs
T13 687-696 multi_cell denotes arthritis
T14 697-705 multi_cell denotes patients
T15 735-743 protein_family_or_group denotes cytokine
T16 759-763 protein_family_or_group denotes STAT
T17 779-817 other_name denotes inflammatory synovial microenvironment
T18 831-834 cell_type denotes SFs
T19 883-905 protein_molecule denotes interferon (IFN)-gamma
T20 915-933 protein_molecule denotes interleukin (IL) 4
T21 949-963 cell_type denotes effector cells
T22 995-1009 other_name denotes SF suppression
T23 1026-1030 protein_molecule denotes IL-4
T24 1035-1040 protein_molecule denotes IL-10
T25 1059-1064 protein_molecule denotes IL-12
T26 1139-1142 cell_type denotes SFs
T27 1177-1203 protein_molecule denotes transcription factor Stat1
T28 1213-1218 protein_molecule denotes Stat3
T29 1251-1256 protein_family_or_group denotes Stat1
T30 1298-1307 protein_family_or_group denotes cytokines
T31 1366-1375 protein_molecule denotes IFN-gamma
T32 1395-1400 protein_molecule denotes Stat3
T33 1410-1415 protein_family_or_group denotes Stat1
T34 1444-1459 body_part denotes inflamed joints
T35 1575-1581 cell_type denotes T cell
T36 1609-1621 other_name denotes pathogenesis
T37 1625-1647 other_name denotes inflammatory synovitis