PubMed:74953 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/74953","sourcedb":"PubMed","sourceid":"74953","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/74953","text":"Amniotic fluid alpha-fetoprotein elevation with fetal omphalocele and a possible mechanism for its occurrence.\nPrenatal diagnosis of genetic disease and congenital malformations has become a major area of study in obstetrics. The assessment of amniotic fluid alpha-fetoprotein (AFP) is useful for the diagnosis of neural tube defects. As more patients have been evaluated abnormal increases have been found in other defects, such as omphalocele, duodenal atresia, and congenital nephrosis. Two patients with omphalocele are reported with AFP measurement. A tenfold elevation of AFP was found in the first patient. In the second case a small omphalocele associated with exstrophy of the cloaca was not accompanied by an abnormal AFP increase. The mechanism of AFP elevation is discussed.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":0,"end":14},"obj":"http://purl.obolibrary.org/obo/UBERON_0000173"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":244,"end":258},"obj":"http://purl.obolibrary.org/obo/UBERON_0000173"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":314,"end":325},"obj":"http://purl.obolibrary.org/obo/UBERON_0001049"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":321,"end":325},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":686,"end":692},"obj":"http://purl.obolibrary.org/obo/UBERON_0000162"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":110},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":111,"end":225},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":226,"end":334},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":335,"end":489},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":490,"end":554},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":555,"end":613},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":614,"end":741},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":742,"end":786},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":110},"obj":"Sentence"},{"id":"T2","span":{"begin":111,"end":225},"obj":"Sentence"},{"id":"T3","span":{"begin":226,"end":334},"obj":"Sentence"},{"id":"T4","span":{"begin":335,"end":489},"obj":"Sentence"},{"id":"T5","span":{"begin":490,"end":554},"obj":"Sentence"},{"id":"T6","span":{"begin":555,"end":613},"obj":"Sentence"},{"id":"T7","span":{"begin":614,"end":741},"obj":"Sentence"},{"id":"T8","span":{"begin":742,"end":786},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":0,"end":14},"obj":"http://purl.obolibrary.org/obo/UBERON_0000173"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":244,"end":258},"obj":"http://purl.obolibrary.org/obo/UBERON_0000173"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":314,"end":325},"obj":"http://purl.obolibrary.org/obo/UBERON_0001049"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":321,"end":325},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":686,"end":692},"obj":"http://purl.obolibrary.org/obo/UBERON_0000162"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"UBERON-AE"}]},{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":54,"end":65},"obj":"HP:0001539"},{"id":"AB1","span":{"begin":314,"end":333},"obj":"HP:0045005"},{"id":"AB2","span":{"begin":433,"end":444},"obj":"HP:0001539"},{"id":"AB3","span":{"begin":446,"end":462},"obj":"HP:0002247"},{"id":"AB4","span":{"begin":508,"end":519},"obj":"HP:0001539"},{"id":"AB5","span":{"begin":641,"end":652},"obj":"HP:0001539"},{"id":"AB6","span":{"begin":669,"end":678},"obj":"HP:0100548"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"},{"subj":"AB3","pred":"source","obj":"PubCasesHPO"},{"subj":"AB4","pred":"source","obj":"PubCasesHPO"},{"subj":"AB5","pred":"source","obj":"PubCasesHPO"},{"subj":"AB6","pred":"source","obj":"PubCasesHPO"}]},{"project":"PubCasesORDO","denotations":[{"id":"TI1","span":{"begin":54,"end":65},"obj":"ORDO:660"},{"id":"AB1","span":{"begin":433,"end":444},"obj":"ORDO:660"},{"id":"AB2","span":{"begin":446,"end":462},"obj":"ORDO:1203"},{"id":"AB3","span":{"begin":508,"end":519},"obj":"ORDO:660"},{"id":"AB4","span":{"begin":641,"end":652},"obj":"ORDO:660"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB2","pred":"source","obj":"PubCasesORDO"},{"subj":"AB3","pred":"source","obj":"PubCasesORDO"},{"subj":"AB4","pred":"source","obj":"PubCasesORDO"}]},{"project":"sonoma","denotations":[{"id":"T-0","span":{"begin":15,"end":32},"obj":"GENE"},{"id":"T-1","span":{"begin":33,"end":42},"obj":"POSREG"},{"id":"T-2","span":{"begin":54,"end":65},"obj":"DISEASE"},{"id":"T-3","span":{"begin":99,"end":109},"obj":"REG"},{"id":"T-4","span":{"begin":259,"end":276},"obj":"GENE"},{"id":"T-5","span":{"begin":278,"end":281},"obj":"GENE"},{"id":"T-6","span":{"begin":286,"end":292},"obj":"REG"},{"id":"T-7","span":{"begin":301,"end":310},"obj":"REG"},{"id":"T-8","span":{"begin":314,"end":333},"obj":"DISEASE"},{"id":"T-9","span":{"begin":381,"end":390},"obj":"POSREG"},{"id":"T-10","span":{"begin":401,"end":406},"obj":"REG"},{"id":"T-11","span":{"begin":433,"end":444},"obj":"DISEASE"},{"id":"T-12","span":{"begin":446,"end":462},"obj":"DISEASE"},{"id":"T-13","span":{"begin":468,"end":488},"obj":"DISEASE"},{"id":"T-14","span":{"begin":508,"end":519},"obj":"DISEASE"},{"id":"T-15","span":{"begin":538,"end":541},"obj":"GENE"},{"id":"T-16","span":{"begin":565,"end":574},"obj":"POSREG"},{"id":"T-17","span":{"begin":578,"end":581},"obj":"GENE"},{"id":"T-18","span":{"begin":586,"end":591},"obj":"REG"},{"id":"T-19","span":{"begin":641,"end":652},"obj":"DISEASE"},{"id":"T-20","span":{"begin":653,"end":663},"obj":"REG"},{"id":"T-21","span":{"begin":669,"end":692},"obj":"DISEASE"},{"id":"T-22","span":{"begin":701,"end":712},"obj":"REG"},{"id":"T-23","span":{"begin":728,"end":731},"obj":"GENE"},{"id":"T-24","span":{"begin":732,"end":740},"obj":"POSREG"},{"id":"T-25","span":{"begin":759,"end":762},"obj":"GENE"},{"id":"T-26","span":{"begin":763,"end":772},"obj":"POSREG"}],"relations":[{"id":"R-20","pred":"ThemeOf","subj":"T-16","obj":"T-17"},{"id":"R-21","pred":"ThemeOf","subj":"T-16","obj":"T-18"},{"id":"R-22","pred":"ThemeOf","subj":"T-17","obj":"T-18"},{"id":"R-23","pred":"ThemeOf","subj":"T-19","obj":"T-20"},{"id":"R-24","pred":"ThemeOf","subj":"T-19","obj":"T-22"},{"id":"R-25","pred":"ThemeOf","subj":"T-20","obj":"T-21"},{"id":"R-26","pred":"ThemeOf","subj":"T-21","obj":"T-22"},{"id":"R-27","pred":"ThemeOf","subj":"T-22","obj":"T-23"},{"id":"R-28","pred":"ThemeOf","subj":"T-23","obj":"T-24"},{"id":"R-29","pred":"ThemeOf","subj":"T-25","obj":"T-26"},{"id":"R-0","pred":"ThemeOf","subj":"T-0","obj":"T-1"},{"id":"R-1","pred":"A","subj":"T-0","obj":"T-2"},{"id":"R-2","pred":"ThemeOf","subj":"T-1","obj":"T-2"},{"id":"R-3","pred":"ThemeOf","subj":"T-2","obj":"T-3"},{"id":"R-4","pred":"ThemeOf","subj":"T-4","obj":"T-6"},{"id":"R-5","pred":"ThemeOf","subj":"T-4","obj":"T-7"},{"id":"R-6","pred":"A","subj":"T-4","obj":"T-8"},{"id":"R-7","pred":"ThemeOf","subj":"T-5","obj":"T-6"},{"id":"R-8","pred":"ThemeOf","subj":"T-5","obj":"T-7"},{"id":"R-9","pred":"A","subj":"T-5","obj":"T-8"},{"id":"R-10","pred":"ThemeOf","subj":"T-6","obj":"T-7"},{"id":"R-11","pred":"ThemeOf","subj":"T-6","obj":"T-8"},{"id":"R-12","pred":"ThemeOf","subj":"T-7","obj":"T-8"},{"id":"R-13","pred":"ThemeOf","subj":"T-9","obj":"T-10"},{"id":"R-14","pred":"ThemeOf","subj":"T-9","obj":"T-11"},{"id":"R-15","pred":"ThemeOf","subj":"T-9","obj":"T-12"},{"id":"R-16","pred":"ThemeOf","subj":"T-9","obj":"T-13"},{"id":"R-17","pred":"ThemeOf","subj":"T-10","obj":"T-11"},{"id":"R-18","pred":"ThemeOf","subj":"T-10","obj":"T-12"},{"id":"R-19","pred":"ThemeOf","subj":"T-10","obj":"T-13"}],"attributes":[{"subj":"T-0","pred":"source","obj":"sonoma"},{"subj":"T-1","pred":"source","obj":"sonoma"},{"subj":"T-2","pred":"source","obj":"sonoma"},{"subj":"T-3","pred":"source","obj":"sonoma"},{"subj":"T-4","pred":"source","obj":"sonoma"},{"subj":"T-5","pred":"source","obj":"sonoma"},{"subj":"T-6","pred":"source","obj":"sonoma"},{"subj":"T-7","pred":"source","obj":"sonoma"},{"subj":"T-8","pred":"source","obj":"sonoma"},{"subj":"T-9","pred":"source","obj":"sonoma"},{"subj":"T-10","pred":"source","obj":"sonoma"},{"subj":"T-11","pred":"source","obj":"sonoma"},{"subj":"T-12","pred":"source","obj":"sonoma"},{"subj":"T-13","pred":"source","obj":"sonoma"},{"subj":"T-14","pred":"source","obj":"sonoma"},{"subj":"T-15","pred":"source","obj":"sonoma"},{"subj":"T-16","pred":"source","obj":"sonoma"},{"subj":"T-17","pred":"source","obj":"sonoma"},{"subj":"T-18","pred":"source","obj":"sonoma"},{"subj":"T-19","pred":"source","obj":"sonoma"},{"subj":"T-20","pred":"source","obj":"sonoma"},{"subj":"T-21","pred":"source","obj":"sonoma"},{"subj":"T-22","pred":"source","obj":"sonoma"},{"subj":"T-23","pred":"source","obj":"sonoma"},{"subj":"T-24","pred":"source","obj":"sonoma"},{"subj":"T-25","pred":"source","obj":"sonoma"},{"subj":"T-26","pred":"source","obj":"sonoma"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#b7ec93","default":true},{"id":"sentences","color":"#ec93d1"},{"id":"UBERON-AE","color":"#93ebec"},{"id":"PubCasesHPO","color":"#ecd393"},{"id":"PubCasesORDO","color":"#b993ec"},{"id":"sonoma","color":"#93ec9f"}]}]}}