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PubMed:7471212 JSONTXT

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Test-Species-PubTator

Id Subject Object Predicate Lexical cue resolved_to
2 15-24 Chemical denotes galactose MESH:D005690
3 68-79 Chemical denotes Man6P-ricin -
30 81-98 Chemical denotes N-acetylimidazole MESH:C012160
31 100-103 Chemical denotes NAI MESH:C012160
32 185-193 Chemical denotes tyrosine MESH:D014443
33 252-264 Chemical denotes Sepharose 4B MESH:D012685
34 279-287 Disease denotes toxicity MESH:D064420
35 338-342 CellLine denotes HeLa CVCL:0030
36 350-357 Chemical denotes Lactose MESH:D007785
37 436-439 Chemical denotes NAI MESH:C012160
38 467-475 Disease denotes toxicity MESH:D064420
39 482-485 Chemical denotes NAI MESH:C012160
40 520-527 Chemical denotes lactose MESH:D007785
41 557-564 Chemical denotes lactose MESH:D007785
42 613-624 Chemical denotes Man6P-ricin -
43 724-732 Disease denotes toxicity MESH:D064420
44 740-749 Chemical denotes galactose MESH:D005690
45 779-787 Disease denotes toxicity MESH:D064420
46 798-809 Chemical denotes Man6P-ricin -
47 843-850 Chemical denotes lactose MESH:D007785
48 912-923 Chemical denotes Man6P-ricin -
49 1001-1014 Gene denotes neuraminidase 4758
50 1023-1032 Chemical denotes galactose MESH:D005690
51 1124-1132 Disease denotes toxicity MESH:D064420
52 1136-1147 Chemical denotes Man6P-ricin -
53 1196-1205 Chemical denotes galactose MESH:D005690
54 1253-1264 Chemical denotes Man6P-ricin -
55 1309-1318 Chemical denotes galactose MESH:D005690

Test-Species-PubDictionaries-PubMedBERT

Id Subject Object Predicate Lexical cue db_id
T1 100-103 Species denotes NAI 85919|74730
T3 133-143 Species denotes plant seed 58024
T4 436-439 Species denotes NAI 85919|74730
T6 482-485 Species denotes NAI 85919|74730
T8 646-650 Species denotes same 582003
T9 677-681 Species denotes same 582003
T10 1406-1410 Species denotes data 1369087

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 350-357 Glycan denotes Lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T2 520-527 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T3 557-564 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T4 843-850 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 350-357 Glycan denotes Lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T2 520-527 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T3 557-564 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T4 843-850 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 984-995 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 984-995 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T2 1345-1352 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-80 Sentence denotes Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin.
T2 81-156 Sentence denotes N-acetylimidazole (NAI) was used to O-acetylate the plant seed toxin ricin.
T3 157-349 Sentence denotes O-acetylation of one to two tyrosine residues per molecule of ricin inhibited ricin binding to Sepharose 4B and decreased toxicity by 90% in a protein synthesis inhibition assay in HeLa cells.
T4 350-476 Sentence denotes Lactose, known to block the binding site on the ricin B subunit, protected ricin from NAI modification of binding or toxicity.
T5 477-552 Sentence denotes Thus NAI, under these conditions, can be a lactose site-specific inhibitor.
T6 553-819 Sentence denotes The lactose site-specific modification of the hybrid toxin, Man6P-ricin, performed under the same conditions, exhibited the same 90% inhibition of Man6P receptor-mediated toxicity as the galactose-containing receptor-mediated toxicity of either Man6P-ricin or ricin.
T7 820-970 Sentence denotes Thus the ricin B chain lactose-binding site appears to be essential for the high potency of Man6P-ricin via the new cell type-specific Man6P receptor.
T8 971-1095 Sentence denotes Treatment of fibroblasts with neuraminidase exposes galactose residues, thus increasing the sensitivity to ricin eight fold.
T9 1096-1248 Sentence denotes The Man6P receptor-mediated toxicity of Man6P-ricin is not affected by this treatment, although the galactose-inhibited route is potentiated eight fold.
T10 1249-1399 Sentence denotes The Man6P-ricin hybrid appears to require the ricin B chain galactose-binding site to enter the cytosol after initially binding to the Man6P receptor.
T11 1400-1473 Sentence denotes These data provide some insights into the proper design of hybrid toxins.
T12 1474-1536 Sentence denotes We discuss a number of possible models for hybrid toxin entry.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 984-995 Body_part denotes fibroblasts FMA:63877
T2 1345-1352 Body_part denotes cytosol FMA:66836

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 984-995 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T2 1345-1352 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 984-995 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057