PubMed:7426320 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7426320","sourcedb":"PubMed","sourceid":"7426320","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7426320","text":"Circulating immunoreactive and bioassayable opsonic plasma fibronectin during experimental tumour growth.\nImmunoreactive and bioassayable plasma fibronectin (opsonic α(2) surface-binding (SB) glycoprotein) was measured during experimental Sarcoma-180 tumour growth in mice. Male C57BL/6 mice were challenged s.c. with 2 × 10(6) viable Sarcoma-180 tumour cells and evaluated sequentially in parallel with saline-injected controls over a 21-day experimental period. Before challenge, immunoreactive plasma fibronectin was 1050-1150 μg/ml. Minimal tumour growth occurred until 6 days after tumour challenge. There was then a rapid increase in primary tumour size, especially over the 7-14-day interval, with a plateau of growth over the 18-21-day interval. Immunoreactive plasma fibronectin was significantly (P \u003c 0·05) raised at 3 and 7 days after tumour challenge. A rapid rise (P \u003c 0·001) to 2816·6 ± 158·9 μg/ml was observed at 14 days followed by a modest decline at 21 days. Bioassayable opsonic activity increased (P \u003c 0·5) with the rise in immunoreactive fibronectin 3 and 7 days after tumour challenge, but the rapid rise in immunoreactive fibronectin over the 7-14-day interval was associated with a significant (P \u003c 0·5) fall in bioassayable opsonic activity. Thus, the rapid rise in immunoreactive plasma fibronectin parallels the rapid rate of tumour growth, but is associated with a fall in opsonically active plasma fibronectin. Dissociation between immunoreactive and opsonically active plasma fibronectin may be mediated by inhibition and/or alteration of circulating fibronectin during rapid tumour growth. Alternatively, it may reflect increased release of antigenically related protein (i.e. cell-surface fibronectin) during rapid tumour growth, which may have limited biological opsonic activity.","tracks":[{"project":"NEUROSES","denotations":[{"id":"T1","span":{"begin":59,"end":70},"obj":"CHEBI_5058"},{"id":"T2","span":{"begin":145,"end":156},"obj":"CHEBI_5058"},{"id":"T3","span":{"begin":504,"end":515},"obj":"CHEBI_5058"},{"id":"T4","span":{"begin":776,"end":787},"obj":"CHEBI_5058"},{"id":"T5","span":{"begin":1060,"end":1071},"obj":"CHEBI_5058"},{"id":"T6","span":{"begin":1146,"end":1157},"obj":"CHEBI_5058"},{"id":"T7","span":{"begin":1314,"end":1325},"obj":"CHEBI_5058"},{"id":"T8","span":{"begin":1428,"end":1439},"obj":"CHEBI_5058"},{"id":"T9","span":{"begin":1507,"end":1518},"obj":"CHEBI_5058"},{"id":"T10","span":{"begin":1582,"end":1593},"obj":"CHEBI_5058"},{"id":"T11","span":{"begin":1722,"end":1733},"obj":"CHEBI_5058"},{"id":"T12","span":{"begin":192,"end":204},"obj":"CHEBI_17089"},{"id":"T13","span":{"begin":274,"end":278},"obj":"PATO_0000384"},{"id":"T14","span":{"begin":274,"end":278},"obj":"CHEBI_30780"},{"id":"T15","span":{"begin":328,"end":334},"obj":"PATO_0000719"},{"id":"T16","span":{"begin":456,"end":462},"obj":"PATO_0001309"},{"id":"T17","span":{"begin":537,"end":544},"obj":"PATO_0002123"},{"id":"T18","span":{"begin":655,"end":659},"obj":"PATO_0000117"},{"id":"T19","span":{"begin":817,"end":823},"obj":"PATO_0001369"},{"id":"T20","span":{"begin":1008,"end":1017},"obj":"PATO_0000470"},{"id":"T21","span":{"begin":1652,"end":1661},"obj":"PATO_0000470"},{"id":"T24","span":{"begin":1346,"end":1350},"obj":"PATO_0001470"},{"id":"T25","span":{"begin":1346,"end":1350},"obj":"PATO_0000161"},{"id":"T26","span":{"begin":1414,"end":1420},"obj":"PATO_0002354"},{"id":"T27","span":{"begin":1493,"end":1499},"obj":"PATO_0002354"},{"id":"T28","span":{"begin":1695,"end":1702},"obj":"CHEBI_36080"},{"id":"T29","span":{"begin":1695,"end":1702},"obj":"CHEBI_16541"},{"id":"T30","span":{"begin":1778,"end":1785},"obj":"PATO_0000392"}],"attributes":[{"subj":"T1","pred":"source","obj":"NEUROSES"},{"subj":"T2","pred":"source","obj":"NEUROSES"},{"subj":"T3","pred":"source","obj":"NEUROSES"},{"subj":"T4","pred":"source","obj":"NEUROSES"},{"subj":"T5","pred":"source","obj":"NEUROSES"},{"subj":"T6","pred":"source","obj":"NEUROSES"},{"subj":"T7","pred":"source","obj":"NEUROSES"},{"subj":"T8","pred":"source","obj":"NEUROSES"},{"subj":"T9","pred":"source","obj":"NEUROSES"},{"subj":"T10","pred":"source","obj":"NEUROSES"},{"subj":"T11","pred":"source","obj":"NEUROSES"},{"subj":"T12","pred":"source","obj":"NEUROSES"},{"subj":"T13","pred":"source","obj":"NEUROSES"},{"subj":"T14","pred":"source","obj":"NEUROSES"},{"subj":"T15","pred":"source","obj":"NEUROSES"},{"subj":"T16","pred":"source","obj":"NEUROSES"},{"subj":"T17","pred":"source","obj":"NEUROSES"},{"subj":"T18","pred":"source","obj":"NEUROSES"},{"subj":"T19","pred":"source","obj":"NEUROSES"},{"subj":"T20","pred":"source","obj":"NEUROSES"},{"subj":"T21","pred":"source","obj":"NEUROSES"},{"subj":"T24","pred":"source","obj":"NEUROSES"},{"subj":"T25","pred":"source","obj":"NEUROSES"},{"subj":"T26","pred":"source","obj":"NEUROSES"},{"subj":"T27","pred":"source","obj":"NEUROSES"},{"subj":"T28","pred":"source","obj":"NEUROSES"},{"subj":"T29","pred":"source","obj":"NEUROSES"},{"subj":"T30","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#a7ec93","default":true}]}]}}