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PubMed:7351028 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Synthesis and antitumor activity of cytosine and adenine nucleosides of unsaturated 5-(aminoacyl)aminopentofuranoses.
TextSentencer_T2 118-454 Sentence denotes Direct synthesis of the 1- and 9-(5-azido-2,3,5-trideoxy-beta-D-glycero-pent-2-enofuranosyl) derivatives (3a and 3b) of cytosine and adenine, respectively, has been accomplished via treatment of the corresponding 2',3'-unsaturated nucleosides (1a and 1b) with triphenylphosphine and carbon tetrabromide in the presence of lithium azide.
TextSentencer_T3 455-814 Sentence denotes Members of a new type of (aminoacyl)amino nucleoside, the 1- and 9-[5-(aminoacyl)amino-2,3,5-trideoxy-beta-D-glycero-pent-2-enofuranosyl] derivatives of cytosine and adenine, respectively, have been obtained by condensation of the corresponding, unsaturated amino nucleosides with the active esters of several amino acid derivatives, followed by deprotection.
TextSentencer_T4 815-1174 Sentence denotes These nucleosides were examined for in vivo antitumor activity against leukemia L-1210 and Sarcoma 180 (solid tumor) in mice; none of them exhibited antitumor activity against L-1210 in mice, but compounds 1a, 3a, and 1-[2,3,5-trideoxy-5-(L-methionyl)amino-beta-D-glycero-pent-2-enofuranosyl]cytosine exhibited weak activity against Sarcoma 180 (solid tumor).
T1 0-117 Sentence denotes Synthesis and antitumor activity of cytosine and adenine nucleosides of unsaturated 5-(aminoacyl)aminopentofuranoses.
T2 118-454 Sentence denotes Direct synthesis of the 1- and 9-(5-azido-2,3,5-trideoxy-beta-D-glycero-pent-2-enofuranosyl) derivatives (3a and 3b) of cytosine and adenine, respectively, has been accomplished via treatment of the corresponding 2',3'-unsaturated nucleosides (1a and 1b) with triphenylphosphine and carbon tetrabromide in the presence of lithium azide.
T3 455-814 Sentence denotes Members of a new type of (aminoacyl)amino nucleoside, the 1- and 9-[5-(aminoacyl)amino-2,3,5-trideoxy-beta-D-glycero-pent-2-enofuranosyl] derivatives of cytosine and adenine, respectively, have been obtained by condensation of the corresponding, unsaturated amino nucleosides with the active esters of several amino acid derivatives, followed by deprotection.
T4 815-1174 Sentence denotes These nucleosides were examined for in vivo antitumor activity against leukemia L-1210 and Sarcoma 180 (solid tumor) in mice; none of them exhibited antitumor activity against L-1210 in mice, but compounds 1a, 3a, and 1-[2,3,5-trideoxy-5-(L-methionyl)amino-beta-D-glycero-pent-2-enofuranosyl]cytosine exhibited weak activity against Sarcoma 180 (solid tumor).

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 886-894 Phenotype denotes leukemia HP:0001909
T2 906-913 Phenotype denotes Sarcoma HP:0100242
T3 925-930 Phenotype denotes tumor HP:0002664
T4 1148-1155 Phenotype denotes Sarcoma HP:0100242
T5 1167-1172 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 886-894 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T2 906-913 Disease denotes Sarcoma http://purl.obolibrary.org/obo/MONDO_0005089
T3 925-930 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 1148-1155 Disease denotes Sarcoma http://purl.obolibrary.org/obo/MONDO_0005089
T5 1167-1172 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 935-939 OrganismTaxon denotes mice 10088
T2 1001-1005 OrganismTaxon denotes mice 10088