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PubMed:7032594 JSONTXT

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Test-Species-PubTator

Id Subject Object Predicate Lexical cue resolved_to
2 0-7 Chemical denotes Lactose MESH:D007785
3 36-52 Species denotes Escherichia coli 562
23 241-257 Species denotes Escherichia coli 562
24 758-769 Chemical denotes galactoside MESH:D005697
25 978-993 Chemical denotes Ga galactosides -
26 995-1012 Chemical denotes thiodigalactoside MESH:C031803
27 1014-1023 Chemical denotes melibiose MESH:D008553
28 1025-1054 Chemical denotes alpha-p-nitrophenygalactoside -
29 1077-1098 Chemical denotes Class Gb galactosides -
30 1100-1107 Chemical denotes lactose -
31 1109-1138 Chemical denotes beta-o-nitrophenylgalactoside -
32 1140-1169 Chemical denotes beta-isopropylthiogalactoside -
33 1267-1288 Chemical denotes Class Gb galactosides -
34 1330-1345 Chemical denotes Ga galactosides -
35 1391-1396 Chemical denotes thiol MESH:D013438
36 1423-1439 Chemical denotes N-ethylmaleimide MESH:D005033
37 1486-1497 Chemical denotes galactoside MESH:D005697
38 1547-1552 Chemical denotes thiol MESH:D013438
39 1587-1592 Chemical denotes thiol MESH:D013438
40 1710-1716 Chemical denotes thiols MESH:D013438
41 2115-2126 Chemical denotes galactoside MESH:D005697

Test-Species-PubDictionaries

Id Subject Object Predicate Lexical cue db_id
T1 36-52 OrganismTaxon denotes Escherichia coli 562
T2 241-257 OrganismTaxon denotes Escherichia coli 562

Test-Species-PubDictionaries-PubMedBERT

Id Subject Object Predicate Lexical cue db_id
T1 36-52 Species denotes Escherichia coli 562
T2 241-257 Species denotes Escherichia coli 562
T3 528-532 Species denotes axis 9855
T4 549-554 Species denotes plane 106761
T5 556-565 Species denotes Lancaster 499986
T6 935-938 Species denotes moA 2681925
T7 1014-1023 Species denotes melibiose 634906
T8 1361-1364 Species denotes moA 2681925
T9 1397-1402 Species denotes group 536441
T10 1514-1517 Species denotes moA 2681925
T11 1624-1627 Species denotes moA 2681925
T12 1792-1795 Species denotes moA 2681925
T13 1824-1828 Species denotes muiA 51460
T14 1888-1893 Species denotes delta 998453
T15 1917-1923 Species denotes m : mu 317406
T16 1992-1998 Species denotes change 1766596
T17 2019-2025 Species denotes m : mu 317406
T18 2145-2151 Species denotes m : mu 317406
T19 2158-2164 Species denotes m : mu 317406

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 0-7 Glycan denotes Lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T2 451-454 Glycan denotes lac https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T3 1014-1023 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T4 1100-1107 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 0-7 Glycan denotes Lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T2 1014-1023 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T3 1100-1107 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1888-1893 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 36-52 Organism denotes Escherichia coli 562
T2 241-257 Organism denotes Escherichia coli 562

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes Lactose-H+(-OH) transport system of Escherichia coli.
T2 54-175 Sentence denotes Multistate gated pore model based on half-sites stoichiometry for high-affinity substrate binding in a symmetrical dimer.
T3 176-358 Sentence denotes A model is proposed for the D-galactoside-H+(-OH) transporter of Escherichia coli that accounts for essentially all the experimental observations established for this system to date.
T4 359-606 Sentence denotes In this model, the functional unit is postulated to be a dimer (consisting of two copies of lac Y-specified polypeptide) which spans the membrane with a 2-fold symmetry axis in the membrane plane (Lancaster, J.R. (1978) J. Theor. Biol. 75, 35-50).
T5 607-805 Sentence denotes The functional dimer is assumed to possess a single pore flanked by an inner gate (gi) and an outer gate (go) and encompassing two oppositely oriented galactoside binding sites, designated m and mu.
T6 806-1602 Sentence denotes When go is open and gi is closed under non-energized conditions, binding site m adopts a configuration defined as State A (i.e., moA) exhibiting high affinity toward Class Ga galactosides (thiodigalactoside, melibiose, alpha-p-nitrophenygalactoside) but low affinity for Class Gb galactosides (lactose, beta-o-nitrophenylgalactoside, beta-isopropylthiogalactoside), whereas binding site mu adopts State B (i.e., muoB) displaying relatively high affinity toward Class Gb galactosides but comparatively low affinity for Class Ga galactosides; further, each moA : muoB dimer contains one thiol group whose reaction with N-ethylmaleimide inactivates the transporter unless blocked by galactoside binding at site moA, while the second homologous thiol of the dimer is unreactive toward thiol reagents.
T7 1603-1829 Sentence denotes Translocation of the moA : muoB dimer involves closing of go followed by opening of gi, and causes the two thiols (as well as sites m and mu) to interchange roles in a symmetrical fashion: moA : muoB in equilibrium miB : muiA.
T8 1830-2261 Sentence denotes In the presence of a substantial (negative) transmembrane delta potential of muH+, the m : mu dimer is postulated to undergo an electrogenic protein conformation change to a second form, *(m : mu), in which both sites m and mu possess low affinity toward internal Class Gb substrates; galactoside transport in both m : mu and *(m : mu) is assumed to be coupled to H+-symport (-OH-antiport) with a stoichiometry of approximately 1 :
T9 2262-2264 Sentence denotes 1.
T10 2265-2377 Sentence denotes Finally, five characteristic predictions of the half-sites model are outlined for further tests of its validity.

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 71-75 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T2 496-504 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T3 528-532 Body_part denotes axis http://purl.obolibrary.org/obo/UBERON_0001093
T4 540-548 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T5 659-663 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T6 1676-1683 Body_part denotes opening http://purl.obolibrary.org/obo/UBERON_0004111

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 36-52 OrganismTaxon denotes Escherichia coli 562
T2 241-257 OrganismTaxon denotes Escherichia coli 562

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 71-75 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T2 496-504 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 528-532 Body_part denotes axis http://purl.obolibrary.org/obo/UBERON_0001093
T6 540-548 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T9 659-663 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T10 1676-1683 Body_part denotes opening http://purl.obolibrary.org/obo/UBERON_0004111
T11 1874-1887 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1888-1893 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124