PubMed:6867654 JSONTXT

{"project":"QFMC_MEDLINE","denotations":[{"id":"T1","span":{"begin":55,"end":132},"obj":"DISO"},{"id":"T1c","span":{"begin":55,"end":132},"obj":"UMLS:C0947622"},{"id":"T2","span":{"begin":287,"end":365},"obj":"PROC"},{"id":"T2c","span":{"begin":287,"end":365},"obj":"UMLS:C0087111"},{"id":"T3","span":{"begin":536,"end":677},"obj":"CHEM"},{"id":"T3c","span":{"begin":536,"end":677},"obj":"UMLS:C0042105"}],"relations":[{"id":"#1","pred":"Normalization","subj":"T1","obj":"T1c"},{"id":"#2","pred":"Normalization","subj":"T2","obj":"T2c"},{"id":"#3","pred":"Normalization","subj":"T3","obj":"T3c"}],"namespaces":[{"prefix":"UMLS","uri":"https://uts.nlm.nih.gov/metathesaurus.html#"}],"text":"[Dissolution of gallstones based on 6 months treatment with a single daily dose of ursodeoxycholic acid].\n51 patients with radiolucent gallstones of diameter less than or equal to 15 mm were treated for 6 months with a new form of ursodeoxycholic acid (UDCA) in a single dose of 450 mg at bedtime. This new form has 3 components with fractionate liberation. The rate of partial and complete dissolution after 6 months was 63.4%, reaching 85% for gallstones of less than 5 mm diameter. The results show that a single dose of 450 mg UDCA at bedtime is as effective as UDCA at mealtimes in the dissolution of radiolucent gallstones. Administration of the drug once a day should be more acceptable to patients."}