PubMed:6722765 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":12,"end":33},"obj":"gene:2936"},{"id":"T1","span":{"begin":56,"end":63},"obj":"disease:C0041107"},{"id":"T2","span":{"begin":12,"end":33},"obj":"gene:2936"},{"id":"T3","span":{"begin":78,"end":99},"obj":"disease:C0018939"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Erythrocyte glutathione reductase activity and acquired trisomy #8 in various hematologic disorders.\nThe gene for erythrocyte glutathione reductase (E-GR) activity has been assigned to chromosome #8. In the present series, we examined the E-GR activity in 14 cases with chronic myelodysplastic syndrome (CMS, preleukemia), atypical acute myelogenous leukemia (AML), or chronic myelogenous leukemia (CML), with and without acquired trisomy #8. No difference in the incidence of high levels of this enzyme was found between two groups, i.e., those with and without trisomy #8 suggesting the existence of a complex regulatory system in addition to chromosome #8."}