PubMed:6695415 JSONTXT

{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":19},"obj":"Disease"},{"id":"T2","span":{"begin":36,"end":55},"obj":"Chemical"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Chemical"},{"id":"T4","span":{"begin":86,"end":105},"obj":"Chemical"},{"id":"T5","span":{"begin":107,"end":110},"obj":"Chemical"},{"id":"T6","span":{"begin":183,"end":189},"obj":"Disease"},{"id":"T7","span":{"begin":217,"end":225},"obj":"Chemical"},{"id":"T8","span":{"begin":296,"end":299},"obj":"Chemical"},{"id":"T9","span":{"begin":300,"end":308},"obj":"Chemical"},{"id":"T10","span":{"begin":321,"end":327},"obj":"Disease"},{"id":"T11","span":{"begin":351,"end":363},"obj":"Disease"},{"id":"T12","span":{"begin":517,"end":529},"obj":"Disease"},{"id":"T13","span":{"begin":517,"end":553},"obj":"Disease"},{"id":"T14","span":{"begin":534,"end":553},"obj":"Disease"},{"id":"T15","span":{"begin":543,"end":553},"obj":"Disease"},{"id":"T16","span":{"begin":578,"end":590},"obj":"Disease"},{"id":"T17","span":{"begin":606,"end":609},"obj":"Chemical"},{"id":"T18","span":{"begin":610,"end":618},"obj":"Chemical"},{"id":"T19","span":{"begin":660,"end":672},"obj":"Disease"},{"id":"T20","span":{"begin":702,"end":714},"obj":"Disease"},{"id":"T21","span":{"begin":751,"end":754},"obj":"Chemical"},{"id":"T22","span":{"begin":755,"end":763},"obj":"Chemical"},{"id":"T23","span":{"begin":776,"end":795},"obj":"Disease"},{"id":"T24","span":{"begin":810,"end":822},"obj":"Disease"}],"text":"Cerebral hemorrhage associated with phenylpropanolamine in combination with caffeine.\nPhenylpropanolamine (PPA) is a drug that has been associated with serious side effects including stroke. It is often combined with caffeine in diet preparations and \"look-alike\" pills. In order to determine if PPA/caffeine can lead to stroke in normotensive and/or hypertensive rats, we administered the combination in six times the allowed human dose calculated on a per weight basis for the rats two times per day for five days. Subarachnoid and cerebral hemorrhage was noted in 18% of the hypertensive rats. A single PPA/caffeine administration (same dose) lead to acute hypertension in both the normotensive and hypertensive animals. These results suggest that PPA/caffeine can lead to cerebral hemorrhage in previously hypertensive animals when administered in greater than the allowed dosage. An acute elevation in blood pressure may be a contributing factor."}