PubMed:6637851 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/6637851","sourcedb":"PubMed","sourceid":"6637851","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/6637851","text":"Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.\nAmiodarone was administered to 154 patients who had sustained, symptomatic ventricular tachycardia (VT) (n = 118) or a cardiac arrest (n = 36) and who were refractory to conventional antiarrhythmic drugs. The loading dose was 800 mg/day for 6 weeks and the maintenance dose was 600 mg/day. Sixty-nine percent of patients continued treatment with amiodarone and had no recurrence of symptomatic VT or ventricular fibrillation (VF) over a follow-up of 6 to 52 months (mean +/- standard deviation 14.2 +/- 8.2). Six percent of the patients had a nonfatal recurrence of VT and were successfully managed by continuing amiodarone at a higher dose or by the addition of a conventional antiarrhythmic drug. One or more adverse drug reactions occurred in 51% of patients. Adverse effects forced a reduction in the dose of amiodarone in 41% and discontinuation of amiodarone in 10% of patients. The most common symptomatic adverse reactions were tremor or ataxia (35%), nausea and anorexia (8%), visual halos or blurring (6%), thyroid function abnormalities (6%) and pulmonary interstitial infiltrates (5%). Although large-dose amiodarone is highly effective in the long-term treatment of VT or VF refractory to conventional antiarrhythmic drugs, it causes significant toxicity in approximately 50% of patients. However, when the dose is adjusted based on clinical response or the development of adverse effects, 75% of patients with VT or VF can be successfully managed with amiodarone.","tracks":[{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":23,"end":31},"obj":"Disease"},{"id":"T2","span":{"begin":45,"end":55},"obj":"Chemical"},{"id":"T3","span":{"begin":68,"end":91},"obj":"Disease"},{"id":"T4","span":{"begin":95,"end":119},"obj":"Disease"},{"id":"T5","span":{"begin":121,"end":131},"obj":"Chemical"},{"id":"T6","span":{"begin":196,"end":219},"obj":"Disease"},{"id":"T7","span":{"begin":221,"end":223},"obj":"Disease"},{"id":"T8","span":{"begin":240,"end":254},"obj":"Disease"},{"id":"T9","span":{"begin":467,"end":477},"obj":"Chemical"},{"id":"T10","span":{"begin":515,"end":517},"obj":"Disease"},{"id":"T11","span":{"begin":521,"end":545},"obj":"Disease"},{"id":"T12","span":{"begin":547,"end":549},"obj":"Disease"},{"id":"T13","span":{"begin":687,"end":689},"obj":"Disease"},{"id":"T14","span":{"begin":734,"end":744},"obj":"Chemical"},{"id":"T15","span":{"begin":934,"end":944},"obj":"Chemical"},{"id":"T16","span":{"begin":975,"end":985},"obj":"Chemical"},{"id":"T17","span":{"begin":1057,"end":1063},"obj":"Disease"},{"id":"T18","span":{"begin":1067,"end":1073},"obj":"Disease"},{"id":"T19","span":{"begin":1081,"end":1087},"obj":"Disease"},{"id":"T20","span":{"begin":1092,"end":1100},"obj":"Disease"},{"id":"T21","span":{"begin":1107,"end":1131},"obj":"Disease"},{"id":"T22","span":{"begin":1138,"end":1168},"obj":"Disease"},{"id":"T23","span":{"begin":1178,"end":1212},"obj":"Disease"},{"id":"T24","span":{"begin":1239,"end":1249},"obj":"Chemical"},{"id":"T25","span":{"begin":1300,"end":1302},"obj":"Disease"},{"id":"T26","span":{"begin":1306,"end":1308},"obj":"Disease"},{"id":"T27","span":{"begin":1380,"end":1388},"obj":"Disease"},{"id":"T28","span":{"begin":1545,"end":1547},"obj":"Disease"},{"id":"T29","span":{"begin":1551,"end":1553},"obj":"Disease"},{"id":"T30","span":{"begin":1587,"end":1597},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T26","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T27","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T28","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T29","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T30","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bc5cdr-valid-experiment","color":"#b793ec","default":true}]}]}}