PubMed:6417659 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/6417659","sourcedb":"PubMed","sourceid":"6417659","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/6417659","text":"Characterization of the human receptor for T-cell growth factor.\nAnti-Tac monoclonal antibody has been identified as a putative antibody against the receptor for T-cell growth factor (TCGF). We now show that: (i) TCGF blocks 85% of 3H-labeled anti-Tac binding to phytohemagglutinin-activated lymphoblasts and (ii) both anti-Tac and anti-TCGF immunoprecipitate a protein band that appears to represent TCGF crosslinked to its receptor on HUT-102B2 cells. In HUT-102B2 cells, the TCGF receptor is a Mr 50,000 glycoprotein with internal disulfide bond(s) and a pI of 5.5-6.0, and it represents approximately equal to 0.05% of total cellular de novo protein synthesis. It contains a peptide of Mr 33,000 that is processed to a mature form that includes N-linked and O-linked sugars and sialic acid.","tracks":[]}