PubMed:6256461 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/6256461","sourcedb":"PubMed","sourceid":"6256461","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/6256461","text":"In vitro generation of cytotoxic lymphocytes against radiation- and radiation leukemia virus-induced tumors. III. Suppression of anti-tumor immunity in vitro by lymphocytes of mice undergoing radiation leukemia virus-induced leukemogenesis.\nAdult C57BL/6 mice exposed to fractionated irradiation or inoculated with the radiation leukemia virus (RadLV), develop high incidence (80-100%) of lymphatic leukemias within 3-6 mo. RadLV-induced lymphomas can elicit cytotoxic responses in vitro in lymphocytes of preimmunized syngeneic mice, a reaction that is dependent on the expression of membrane-associated viral antigenicity. As soon as 5 d after RadLV inoculation, and during the entire leukemogenic process, suppressor T cells are detectable in the spleen that are capable of specifically abrogating generation of syngeneic anti-tumor cytotoxic cells in vitro. Mice exposed to fractionated x irradiation do not develop suppressor cells and their splenocytes may be stimulated in vitro to generate cytotoxicity toward RadLV-induced leukemias. These findings suggest that although RadLV has been isolated from radiation-induced leukemias, x-ray- and RadLV-induced leukemogenesis do not seem to involve a common viral etiology, and that induction of suppressor cells during RadLV leukemogenesis may be essential for tumor progression.","tracks":[{"project":"NEUROSES","denotations":[{"id":"T1","span":{"begin":260,"end":267},"obj":"PATO_0001646"},{"id":"T2","span":{"begin":867,"end":874},"obj":"PATO_0001646"},{"id":"T3","span":{"begin":260,"end":267},"obj":"PATO_0002425"},{"id":"T4","span":{"begin":867,"end":874},"obj":"PATO_0002425"},{"id":"T5","span":{"begin":361,"end":365},"obj":"PATO_0000469"},{"id":"T6","span":{"begin":366,"end":375},"obj":"PATO_0000057"},{"id":"T7","span":{"begin":594,"end":604},"obj":"PATO_0001668"},{"id":"T8","span":{"begin":700,"end":707},"obj":"PATO_0000006"}],"attributes":[{"subj":"T1","pred":"source","obj":"NEUROSES"},{"subj":"T2","pred":"source","obj":"NEUROSES"},{"subj":"T3","pred":"source","obj":"NEUROSES"},{"subj":"T4","pred":"source","obj":"NEUROSES"},{"subj":"T5","pred":"source","obj":"NEUROSES"},{"subj":"T6","pred":"source","obj":"NEUROSES"},{"subj":"T7","pred":"source","obj":"NEUROSES"},{"subj":"T8","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#af93ec","default":true}]}]}}