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PubMed:6256086 JSONTXT

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Test-Species-PubTator

Id Subject Object Predicate Lexical cue resolved_to
4 50-53 Gene denotes EGF 13645
5 54-61 Chemical denotes ricin A -
6 86-89 Gene denotes EGF 13645
7 101-111 Chemical denotes fragment A -
30 144-170 Chemical denotes 2-pyridyl-dithiopropionate -
31 185-208 Gene denotes epidermal growth factor 13645
32 210-213 Gene denotes EGF 13645
33 248-257 Chemical denotes disulfide MESH:D004220
34 306-316 Chemical denotes fragment A -
35 348-351 Gene denotes EGF 13645
36 379-382 CellLine denotes 3T3 CVCL:0594
37 453-456 Gene denotes EGF 13645
38 528-536 Disease denotes toxicity MESH:D064420
39 547-554 Chemical denotes Ricin A -
40 710-713 Gene denotes EGF 13645
41 773-776 Gene denotes EGF 13645
42 815-823 Disease denotes Toxicity MESH:D064420
43 831-834 Gene denotes EGF 13645
44 852-855 CellLine denotes 3T3 CVCL:0594
45 878-881 Gene denotes EGF 13645
46 931-938 Chemical denotes lactose MESH:D007785
47 1000-1003 Gene denotes EGF 13645
48 1023-1026 Gene denotes EGF 13645
49 1146-1149 Gene denotes EGF 13645
50 1283-1292 Chemical denotes disulfide MESH:D004220
51 1315-1318 Gene denotes EGF 13645

Test-Species-PubDictionaries-PubMedBERT

Id Subject Object Predicate Lexical cue db_id
T1 90-100 Species denotes diphtheria 695653
T2 320-330 Species denotes diphtheria 695653

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 931-938 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 90-100 Disease denotes diphtheria http://purl.obolibrary.org/obo/MONDO_0005504
T2 320-330 Disease denotes diphtheria http://purl.obolibrary.org/obo/MONDO_0005504

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 931-938 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-16 Body_part denotes Epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T2 185-201 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 90-100 Disease denotes diphtheria MONDO:0005504
T2 320-330 Disease denotes diphtheria MONDO:0005504

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Epidermal growth factor-toxin A chain conjugates: EGF-ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic.
T2 125-343 Sentence denotes We have prepared a 2-pyridyl-dithiopropionate derivative of epidermal growth factor (EGF) and conjugated the derivative by disulfide interchange to the A chain of ricin (RTA) or to fragment A of diphtheria toxin (DTA).
T3 344-546 Sentence denotes The EGF-RTA conjugate was toxic to 3T3 cells at concentrations (10(-9)--10(-11) M) similar to those at which EGF exerts its biological activity and within an order of magnitude of the toxicity of ricin.
T4 547-737 Sentence denotes Ricin A chain alone only exerted toxic effects at concentrations (10(-6)--10(-7) M) three to four orders of magnitude higher than required for the activity of the EGF-RTA conjugate or ricin.
T5 738-814 Sentence denotes An unconjugated mixture of RTA and EGF had no greater effect than RTA alone.
T6 815-980 Sentence denotes Toxicity of the EGF-RTA conjugate on 3T3 cells was competed by EGF and was blocked by antibodies to RTA, but not by lactose or antibodies to the ricin B chain (RTB).
T7 981-1341 Sentence denotes In contrast to the EGF-RTA conjugate, the EGF-DTA conjugate proved virtually nontoxic at concentrations as high as 3 X 10(-8) M. Control experiments showed that the EGF-DTA conjugate retained EGF receptor binding activity; the DTA moiety of the hybrid retained ADP-ribosyltransferase activity; and the disulfide bridge linking DTA to EGF was readily reducible.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-16 Body_part denotes Epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T2 185-201 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021