PubMed:6248216 JSONTXT

{"project":"PennBioIE","denotations":[{"id":"T1","span":{"begin":0,"end":52},"obj":"protein"},{"id":"T2","span":{"begin":78,"end":91},"obj":"protein"},{"id":"T3","span":{"begin":115,"end":135},"obj":"protein"},{"id":"T4","span":{"begin":160,"end":219},"obj":"protein"},{"id":"T5","span":{"begin":244,"end":264},"obj":"protein"},{"id":"T6","span":{"begin":415,"end":430},"obj":"protein"},{"id":"T7","span":{"begin":441,"end":461},"obj":"protein"},{"id":"T8","span":{"begin":490,"end":504},"obj":"protein"},{"id":"T9","span":{"begin":534,"end":554},"obj":"protein"},{"id":"T10","span":{"begin":629,"end":641},"obj":"protein"},{"id":"T11","span":{"begin":716,"end":736},"obj":"protein"},{"id":"T12","span":{"begin":746,"end":783},"obj":"protein"},{"id":"T13","span":{"begin":844,"end":856},"obj":"protein"}],"text":"Cyclic adenosine 3':5'-monophosphate-binding protein, a biochemical marker of neuroblastoma differentiation.\nMouse neuroblastoma tumors show reduced amounts of cyclic adenosine 3':5'-monophosphate (cAMP) binding protein. However, the levels of cAMP-binding protein were increased by 2-fold when the tumor cells were established in tissue culture, and these levels were comparable to that found in mouse brain. This binding protein is a free cAMP-binding protein that is not associated with protein kinase. The reduced amounts of free cAMP-binding protein in tumors are not a consequence of a defective gene, but the synthesis of this protein is regulated at the transcriptional and/or translational levels. The free cAMP-binding protein like the neurotransmitter-synthesizing enzymes can be used as a biochemical marker of differentiation, and this protein may play a role in neuronal differentiation."}