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PubMed:6213618 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 185-192 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

sentences

Id Subject Object Predicate Lexical cue
T1 0-34 Sentence denotes Control of glycoprotein synthesis.
T2 35-248 Sentence denotes UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides.
T3 249-323 Sentence denotes Hen oviduct membranes are shown to catalyze the following enzyme reaction:
T4 324-590 Sentence denotes GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-6)GlcNAc-Asn + UDP-GlcNAc leads to GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)GlcNAc beta 1-4)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-6)GlcNAc-Asn + UDP.
T5 591-875 Sentence denotes The enzyme catalyzing this reaction has been named UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III (GlcNAc-transferase III) to distinguish it from two other GlcNAc-transferases (I and II) present in hen oviduct and previously described in several mammalian tissues.
T6 876-1034 Sentence denotes GlcNAc-transferases I and II, respectively, attach GlcNAc in beta 1-2 linkage to the Man alpha 1-3 and Man alpha 1-6 arms of Asn-linked oligosaccharide cores.
T7 1035-1248 Sentence denotes A specific assay for GlcNAc-transferase III was devised by using concanavalin A/Sepharose columns to separate the product of transferase III from other interfering radioactive glycopeptides formed in the reaction.
T8 1249-1354 Sentence denotes The specific activity of GlcNAc-transferase III in hen oviduct membranes is about 5 nmol/mg of protein/h.
T9 1355-1517 Sentence denotes Substrate specificity studies have shown that GlcNAc-transferase III requires both terminal beta 1-2-linked GlcNAc residues in its substrate for maximal activity.
T10 1518-1675 Sentence denotes Removal of the GlcNAc residue on the Man alpha 1-6 arm reduces activity by at least 85% and removal of both GlcNAc residues reduces activity by at least 93%.
T11 1676-1874 Sentence denotes Two large scale preparations of product were subjected to high resolution proton NMR spectroscopy to establish the incorporation by the enzyme of a GlcNAc in beta 1-4 linkage to the beta-linked Man.
T12 1875-2030 Sentence denotes This GlcNAc residue is called a "bisecting" GlcNAc and appears to play important control functions in the synthesis of complex N-glycosyl oligosaccharides.
T13 2031-2157 Sentence denotes Several enzymes in the biosynthetic scheme are unable to act on glycopeptide substrates containing a bisecting GlcNAc residue.
T1 0-34 Sentence denotes Control of glycoprotein synthesis.
T2 35-248 Sentence denotes UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides.
T3 249-323 Sentence denotes Hen oviduct membranes are shown to catalyze the following enzyme reaction:
T4 324-590 Sentence denotes GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-6)GlcNAc-Asn + UDP-GlcNAc leads to GlcNAc beta 1-2Man alpha 1-6(GlcNAc beta 1-2Man alpha 1-3)GlcNAc beta 1-4)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-6)GlcNAc-Asn + UDP.
T5 591-875 Sentence denotes The enzyme catalyzing this reaction has been named UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III (GlcNAc-transferase III) to distinguish it from two other GlcNAc-transferases (I and II) present in hen oviduct and previously described in several mammalian tissues.
T6 876-1034 Sentence denotes GlcNAc-transferases I and II, respectively, attach GlcNAc in beta 1-2 linkage to the Man alpha 1-3 and Man alpha 1-6 arms of Asn-linked oligosaccharide cores.
T7 1035-1248 Sentence denotes A specific assay for GlcNAc-transferase III was devised by using concanavalin A/Sepharose columns to separate the product of transferase III from other interfering radioactive glycopeptides formed in the reaction.
T8 1249-1354 Sentence denotes The specific activity of GlcNAc-transferase III in hen oviduct membranes is about 5 nmol/mg of protein/h.
T9 1355-1517 Sentence denotes Substrate specificity studies have shown that GlcNAc-transferase III requires both terminal beta 1-2-linked GlcNAc residues in its substrate for maximal activity.
T10 1518-1675 Sentence denotes Removal of the GlcNAc residue on the Man alpha 1-6 arm reduces activity by at least 85% and removal of both GlcNAc residues reduces activity by at least 93%.
T11 1676-1874 Sentence denotes Two large scale preparations of product were subjected to high resolution proton NMR spectroscopy to establish the incorporation by the enzyme of a GlcNAc in beta 1-4 linkage to the beta-linked Man.
T12 1875-2030 Sentence denotes This GlcNAc residue is called a "bisecting" GlcNAc and appears to play important control functions in the synthesis of complex N-glycosyl oligosaccharides.
T13 2031-2157 Sentence denotes Several enzymes in the biosynthetic scheme are unable to act on glycopeptide substrates containing a bisecting GlcNAc residue.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 185-192 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 120-127 http://purl.obolibrary.org/obo/MAT_0000126 denotes oviduct
T2 253-260 http://purl.obolibrary.org/obo/MAT_0000126 denotes oviduct
T3 813-820 http://purl.obolibrary.org/obo/MAT_0000126 denotes oviduct
T4 1304-1311 http://purl.obolibrary.org/obo/MAT_0000126 denotes oviduct

glycogenes

Id Subject Object Predicate Lexical cue
PD-GlycoGenes20190927-B_T1 627-630 https://acgg.asia/db/ggdb/info/gg135 denotes has
PD-GlycoGenes20190927-B_T2 794-796 https://acgg.asia/db/ggdb/info/gg111 denotes II
PD-GlycoGenes20190927-B_T3 902-904 https://acgg.asia/db/ggdb/info/gg111 denotes II
PD-GlycoGenes20190927-B_T4 1680-1685 https://acgg.asia/db/ggdb/info/gg171 denotes large

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 139-145 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 324-330 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 353-359 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T4 424-430 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T5 441-447 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T6 457-463 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T7 486-492 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T8 515-521 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T9 573-579 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T10 710-716 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T11 767-773 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T12 876-882 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T13 927-933 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T14 1056-1062 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T15 1274-1280 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T16 1401-1407 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T17 1463-1469 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T18 1533-1539 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T19 1626-1632 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T20 1824-1830 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T21 1880-1886 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T22 1919-1925 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T23 2142-2148 chem:24139 denotes GlcNAc

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 120-127 Body_part denotes oviduct http://purl.obolibrary.org/obo/MAT_0000126
T2 253-260 Body_part denotes oviduct http://purl.obolibrary.org/obo/MAT_0000126
T3 813-820 Body_part denotes oviduct http://purl.obolibrary.org/obo/MAT_0000126
T4 1304-1311 Body_part denotes oviduct http://purl.obolibrary.org/obo/MAT_0000126

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 120-127 Body_part denotes oviduct http://purl.obolibrary.org/obo/UBERON_0000993
T2 253-260 Body_part denotes oviduct http://purl.obolibrary.org/obo/UBERON_0000993
T3 261-270 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T6 813-820 Body_part denotes oviduct http://purl.obolibrary.org/obo/UBERON_0000993
T7 1304-1311 Body_part denotes oviduct http://purl.obolibrary.org/obo/UBERON_0000993
T8 1312-1321 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T11 1569-1572 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460|http://purl.obolibrary.org/obo/UBERON_0003822
T13 1686-1691 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542