PubMed:6203632 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/6203632","sourcedb":"PubMed","sourceid":"6203632","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/6203632","text":"Development of isoproterenol-induced cardiac hypertrophy.\nThe development of cardiac hypertrophy was studied in adult female Wistar rats following daily subcutaneous injections of isoproterenol (ISO) (0.3 mg/kg body weight). A time course was established for the change in tissue mass, RNA and DNA content, as well as hydroxyproline content. Heart weight increased 44% after 8 days of treatment with a half time of 3.4 days. Ventricular RNA content was elevated 26% after 24 h of a single injection and reached a maximal level following 8 days of therapy. The half time for RNA accumulation was 2.0 days. The total content of hydroxyproline remained stable during the first 2 days of treatment but increased 46% after 4 days of therapy. Ventricular DNA content was unchanged during the early stage (1-4 days) of hypertrophic growth but increased to a new steady-state level 19% above the controls after 8 days of treatment. Intraventricular pressures and coronary flow measures were similar for control and experimental animals following 4 days of developed hypertrophy. However, dP/dt in the ISO-treated hearts was slightly but significantly (P less than 0.05) elevated. These data indicate that the adaptive response to ISO shows an early hypertrophic phase (1-4 days) characterized by a substantial increase in RNA content and cardiac mass in the absence of changes in DNA. However, prolonged stimulation (8-12 days) appears to represent a complex integration of both cellular hypertrophy and hyperplasia within the heart.","tracks":[{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":15,"end":28},"obj":"Chemical"},{"id":"T2","span":{"begin":37,"end":56},"obj":"Disease"},{"id":"T3","span":{"begin":77,"end":96},"obj":"Disease"},{"id":"T4","span":{"begin":180,"end":193},"obj":"Chemical"},{"id":"T5","span":{"begin":195,"end":198},"obj":"Chemical"},{"id":"T6","span":{"begin":318,"end":332},"obj":"Chemical"},{"id":"T7","span":{"begin":626,"end":640},"obj":"Chemical"},{"id":"T8","span":{"begin":812,"end":824},"obj":"Disease"},{"id":"T9","span":{"begin":1058,"end":1069},"obj":"Disease"},{"id":"T10","span":{"begin":1093,"end":1096},"obj":"Chemical"},{"id":"T11","span":{"begin":1222,"end":1225},"obj":"Chemical"},{"id":"T12","span":{"begin":1241,"end":1253},"obj":"Disease"},{"id":"T13","span":{"begin":1480,"end":1491},"obj":"Disease"},{"id":"T14","span":{"begin":1496,"end":1507},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bc5cdr-valid-experiment","color":"#9c93ec","default":true}]}]}}