PubMed:6101415 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":126},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":127,"end":289},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":290,"end":408},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":409,"end":584},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":585,"end":785},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":786,"end":1034},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":126},"obj":"Sentence"},{"id":"T2","span":{"begin":127,"end":289},"obj":"Sentence"},{"id":"T3","span":{"begin":290,"end":408},"obj":"Sentence"},{"id":"T4","span":{"begin":409,"end":584},"obj":"Sentence"},{"id":"T5","span":{"begin":585,"end":785},"obj":"Sentence"},{"id":"T6","span":{"begin":786,"end":1034},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":21,"end":54},"obj":"gene:2539"},{"id":"T1","span":{"begin":93,"end":117},"obj":"disease:C0043194"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"6101415-0#21#54#gene2539","span":{"begin":21,"end":54},"obj":"gene2539"},{"id":"6101415-0#93#117#diseaseC0043194","span":{"begin":93,"end":117},"obj":"diseaseC0043194"},{"id":"6101415-5#50#53#gene7454","span":{"begin":836,"end":839},"obj":"gene7454"},{"id":"6101415-5#149#152#diseaseC0043194","span":{"begin":935,"end":938},"obj":"diseaseC0043194"},{"id":"6101415-5#223#247#diseaseC0043194","span":{"begin":1009,"end":1033},"obj":"diseaseC0043194"}],"relations":[{"id":"21#54#gene253993#117#diseaseC0043194","pred":"associated_with","subj":"6101415-0#21#54#gene2539","obj":"6101415-0#93#117#diseaseC0043194"},{"id":"50#53#gene7454149#152#diseaseC0043194","pred":"associated_with","subj":"6101415-5#50#53#gene7454","obj":"6101415-5#149#152#diseaseC0043194"},{"id":"50#53#gene7454223#247#diseaseC0043194","pred":"associated_with","subj":"6101415-5#50#53#gene7454","obj":"6101415-5#223#247#diseaseC0043194"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":677,"end":683},"obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":869,"end":875},"obj":"http://purl.obolibrary.org/obo/UBERON_0002370"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":677,"end":683},"obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":869,"end":875},"obj":"http://purl.obolibrary.org/obo/UBERON_0002370"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":154,"end":178},"obj":"ORDO:906"},{"id":"TI1","span":{"begin":93,"end":117},"obj":"ORDO:906"},{"id":"AB2","span":{"begin":1009,"end":1033},"obj":"ORDO:906"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":93,"end":117},"obj":"Modifier:D014923"},{"id":"T2","span":{"begin":154,"end":178},"obj":"SpecificDisease:D014923"},{"id":"T3","span":{"begin":180,"end":183},"obj":"SpecificDisease:D014923"},{"id":"T4","span":{"begin":396,"end":399},"obj":"Modifier:D014923"},{"id":"T5","span":{"begin":836,"end":839},"obj":"Modifier:D014923"},{"id":"T6","span":{"begin":935,"end":938},"obj":"SpecificDisease:D014923"},{"id":"T7","span":{"begin":1009,"end":1033},"obj":"SpecificDisease:D014923"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBI-Disease-Train","denotations":[{"id":"T3486","span":{"begin":93,"end":117},"obj":"Modifier"},{"id":"T3487","span":{"begin":154,"end":178},"obj":"SpecificDisease"},{"id":"T3488","span":{"begin":180,"end":183},"obj":"SpecificDisease"},{"id":"T3489","span":{"begin":396,"end":399},"obj":"Modifier"},{"id":"T3490","span":{"begin":836,"end":839},"obj":"Modifier"},{"id":"T3491","span":{"begin":935,"end":938},"obj":"SpecificDisease"},{"id":"T3492","span":{"begin":1009,"end":1033},"obj":"SpecificDisease"}],"attributes":[{"id":"A3486","pred":"database_id","subj":"T3486","obj":"D014923"},{"id":"A3487","pred":"database_id","subj":"T3487","obj":"D014923"},{"id":"A3488","pred":"database_id","subj":"T3488","obj":"D014923"},{"id":"A3489","pred":"database_id","subj":"T3489","obj":"D014923"},{"id":"A3490","pred":"database_id","subj":"T3490","obj":"D014923"},{"id":"A3491","pred":"database_id","subj":"T3491","obj":"D014923"},{"id":"A3492","pred":"database_id","subj":"T3492","obj":"D014923"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T3486","span":{"begin":93,"end":117},"obj":"Modifier"},{"id":"T3487","span":{"begin":154,"end":178},"obj":"SpecificDisease"},{"id":"T3488","span":{"begin":180,"end":183},"obj":"SpecificDisease"},{"id":"T3489","span":{"begin":396,"end":399},"obj":"Modifier"},{"id":"T3490","span":{"begin":836,"end":839},"obj":"Modifier"},{"id":"T3491","span":{"begin":935,"end":938},"obj":"SpecificDisease"},{"id":"T3492","span":{"begin":1009,"end":1033},"obj":"SpecificDisease"}],"attributes":[{"id":"A3486","pred":"database_id","subj":"T3486","obj":"D014923"},{"id":"A3487","pred":"database_id","subj":"T3487","obj":"D014923"},{"id":"A3488","pred":"database_id","subj":"T3488","obj":"D014923"},{"id":"A3489","pred":"database_id","subj":"T3489","obj":"D014923"},{"id":"A3490","pred":"database_id","subj":"T3490","obj":"D014923"},{"id":"A3491","pred":"database_id","subj":"T3491","obj":"D014923"},{"id":"A3492","pred":"database_id","subj":"T3492","obj":"D014923"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":93,"end":117},"obj":"Modifier"},{"id":"T2","span":{"begin":154,"end":178},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":396,"end":1033},"obj":"Modifier"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":93,"end":117},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":154,"end":178},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":180,"end":183},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":396,"end":399},"obj":"Modifier"},{"id":"T5","span":{"begin":836,"end":839},"obj":"Modifier"},{"id":"T6","span":{"begin":935,"end":938},"obj":"Modifier"},{"id":"T7","span":{"begin":1009,"end":1033},"obj":"SpecificDisease"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":93,"end":117},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":154,"end":178},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":935,"end":938},"obj":"Modifier"},{"id":"T4","span":{"begin":1009,"end":1033},"obj":"SpecificDisease"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}

{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":93,"end":117},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":154,"end":184},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":1009,"end":1033},"obj":"SpecificDisease"}],"text":"Allelic exclusion of glucose-6-phosphate dehydrogenase in platelets and T lymphocytes from a Wiskott-Aldrich syndrome carrier.\nAn obligate carrier of the Wiskott-Aldrich syndrome (WAS) who was also heterozygous for the A and B types of X-linked glucose-6-phosphate dehydrogenase was found. With her it became possible to determine whether allelic exclusion occurs in particular cell-types of the WAS carrier. If so, the remaining cells of a particular cell-type would express only the normal X chromosome and only one glucose-6-phosphate dehydrogenase isoenzyme would be demonstrable. This carrier had only the B isoenzyme of glucose-6-phosphate dehydrogenase in platelets and thymus-derived T lymphocytes, although both isoenzymes A and B were present in erythrocytes and neutrophils. These findings suggest that selection against the WAS gene occurs in platelets and thymus-derived T lymphocytes and that the defects associated with WAS expressed in these cell-types may be implicated in the genesis of the Wiskott-Aldrich syndrome."}