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PubMed:5556631 JSONTXT

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Inflammaging

Id	Subject	Object	Predicate	Lexical cue
T1	0-103	Sentence	denotes	A new form of localized allergic encephalomyelitis featuring polymorphonuclear neutrophilic leukocytes.
T2	104-209	Sentence	denotes	Mononuclear inflammatory infiltrates are characteristic of experimental allergic encephalomyelitis (EAE).
T3	210-384	Sentence	denotes	Localized EAE was produced in rats in a single day by passive transfer of living lymphoid cells from immunized donors to non-immunized recipients with thermal brain injuries.
T4	385-567	Sentence	denotes	When the recipients were pretreated with cyclophosphamide 1 or 2 days before cell transfer, neutrophils in the EAE infiltrates notably increased and mononuclear leukocytes decreased.
T5	568-740	Sentence	denotes	This neutrophilic form of EAE was produced with cells from donors immunized with whole neural tissue or purified myelin basic protein and with adjuvants of different types.
T6	741-961	Sentence	denotes	This lesion could not be reproduced if the EAE cells were replaced by EAE serum or by irrelevantly immunized cells, or if their activity was foiled by specific "desensitization" or by use of histoincompatible recipients.
T7	962-1135	Sentence	denotes	The 2-day period during which cyclophosphamide prepared recipients for neutrophilic EAE coincided with a transient lymphopenia and relative neutrocytosis caused by the drug.
T8	1136-1293	Sentence	denotes	The passive transfer system made it possible for the drug to unbalance the recipient's hemopoietic system without risking adverse effects on the donor cells.
T9	1294-1449	Sentence	denotes	The rapid development of the localized form of EAE made it possible to produce lesions before the recipient's transient imbalance gave way to pancytopenia.
T10	1450-1637	Sentence	denotes	The new form of EAE may be useful for investigating autoimmune diseases because the neutrophils which indicate the immunologic injury are instantly recognized as reactive recipient cells.
T11	1638-1741	Sentence	denotes	Preexisting conventional (mononuclear) EAE prevented subsequent production of neutrophilic infiltrates.
T12	1742-1865	Sentence	denotes	This inhibitory effect may be due to local blockade of vessels by mononuclear cells, a concept for which there is evidence.
T13	1866-2125	Sentence	denotes	These considerations suggest that the exudation of neutrophils in the new form of EAE may be due to suppression by cyclophosphamide of the mononuclear component of the inflammatory reaction, with loss of its blockading and protective influence on the vessels.
T1	0-103	Sentence	denotes	A new form of localized allergic encephalomyelitis featuring polymorphonuclear neutrophilic leukocytes.
T2	104-209	Sentence	denotes	Mononuclear inflammatory infiltrates are characteristic of experimental allergic encephalomyelitis (EAE).
T3	210-384	Sentence	denotes	Localized EAE was produced in rats in a single day by passive transfer of living lymphoid cells from immunized donors to non-immunized recipients with thermal brain injuries.
T4	385-567	Sentence	denotes	When the recipients were pretreated with cyclophosphamide 1 or 2 days before cell transfer, neutrophils in the EAE infiltrates notably increased and mononuclear leukocytes decreased.
T5	568-740	Sentence	denotes	This neutrophilic form of EAE was produced with cells from donors immunized with whole neural tissue or purified myelin basic protein and with adjuvants of different types.
T6	741-961	Sentence	denotes	This lesion could not be reproduced if the EAE cells were replaced by EAE serum or by irrelevantly immunized cells, or if their activity was foiled by specific "desensitization" or by use of histoincompatible recipients.
T7	962-1135	Sentence	denotes	The 2-day period during which cyclophosphamide prepared recipients for neutrophilic EAE coincided with a transient lymphopenia and relative neutrocytosis caused by the drug.
T8	1136-1293	Sentence	denotes	The passive transfer system made it possible for the drug to unbalance the recipient's hemopoietic system without risking adverse effects on the donor cells.
T9	1294-1449	Sentence	denotes	The rapid development of the localized form of EAE made it possible to produce lesions before the recipient's transient imbalance gave way to pancytopenia.
T10	1450-1637	Sentence	denotes	The new form of EAE may be useful for investigating autoimmune diseases because the neutrophils which indicate the immunologic injury are instantly recognized as reactive recipient cells.
T11	1638-1741	Sentence	denotes	Preexisting conventional (mononuclear) EAE prevented subsequent production of neutrophilic infiltrates.
T12	1742-1865	Sentence	denotes	This inhibitory effect may be due to local blockade of vessels by mononuclear cells, a concept for which there is evidence.
T13	1866-2125	Sentence	denotes	These considerations suggest that the exudation of neutrophils in the new form of EAE may be due to suppression by cyclophosphamide of the mononuclear component of the inflammatory reaction, with loss of its blockading and protective influence on the vessels.