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PubMed:5112201 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-42 Sentence denotes Biological activity of complement in vivo.
T2 43-131 Sentence denotes Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates.
T3 132-248 Sentence denotes The importance of C5 in the generation of complement (C)-dependent chemotactic activity in vitro is well recognized.
T4 249-399 Sentence denotes However, the actual role C5 may play in the accumulation of polymorphonuclear leukocytes (PMN) at inflammatory sites in vivo has not been established.
T5 400-542 Sentence denotes Injection of glycogen or endotoxin into the peritoneal cavities of guinea pigs resulted, shortly thereafter, in the local accumulation of PMN.
T6 543-643 Sentence denotes Preceding the influx of leukocytes, the peritoneal fluid became chemotactic for rabbit PMN in vitro.
T7 644-728 Sentence denotes The majority of this activity could be attributed to a cleavage product of C5 (C5a).
T8 729-943 Sentence denotes Similarly, injection of endotoxin into the peritoneal cavity of C5-normal mice resulted in the generation of a chemotactic factor for mouse PMN which was followed by the accumulation of PMN in the peritoneal fluid.
T9 944-1187 Sentence denotes In contrast, injection of endotoxin into the peritoneal cavity of C5-deficient mice resulted in the generation of virtually no detectable chemotactic activity and a markedly depressed accumulation of PMN during the first 24 hr after injection.
T10 1188-1313 Sentence denotes The data suggest that C5 plays an important role in the early phases of PMN accumulation in response to inflammatory stimuli.
T11 1314-1528 Sentence denotes The rapid accumulation of PMN in response to an inflammatory stimulus such as bacterial endotoxin would be expected to be a major factor in host defense against proliferation and dissemination of infectious agents.
T1 0-42 Sentence denotes Biological activity of complement in vivo.
T2 43-131 Sentence denotes Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates.
T3 132-248 Sentence denotes The importance of C5 in the generation of complement (C)-dependent chemotactic activity in vitro is well recognized.
T4 249-399 Sentence denotes However, the actual role C5 may play in the accumulation of polymorphonuclear leukocytes (PMN) at inflammatory sites in vivo has not been established.
T5 400-542 Sentence denotes Injection of glycogen or endotoxin into the peritoneal cavities of guinea pigs resulted, shortly thereafter, in the local accumulation of PMN.
T6 543-643 Sentence denotes Preceding the influx of leukocytes, the peritoneal fluid became chemotactic for rabbit PMN in vitro.
T7 644-728 Sentence denotes The majority of this activity could be attributed to a cleavage product of C5 (C5a).
T8 729-943 Sentence denotes Similarly, injection of endotoxin into the peritoneal cavity of C5-normal mice resulted in the generation of a chemotactic factor for mouse PMN which was followed by the accumulation of PMN in the peritoneal fluid.
T9 944-1187 Sentence denotes In contrast, injection of endotoxin into the peritoneal cavity of C5-deficient mice resulted in the generation of virtually no detectable chemotactic activity and a markedly depressed accumulation of PMN during the first 24 hr after injection.
T10 1188-1313 Sentence denotes The data suggest that C5 plays an important role in the early phases of PMN accumulation in response to inflammatory stimuli.
T11 1314-1528 Sentence denotes The rapid accumulation of PMN in response to an inflammatory stimulus such as bacterial endotoxin would be expected to be a major factor in host defense against proliferation and dissemination of infectious agents.