PubMed:5003721 / 99-920 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T2","span":{"begin":0,"end":821},"obj":"Sentence"},{"id":"T2","span":{"begin":0,"end":821},"obj":"Sentence"}],"text":"In penetrating the heart and developing in it, Trypanosoma cruzi produces an immunoallergic reaction that leads to changes in the histological structure of the myocardium; these changes alter the fundamental properties of the heart, causing fundamental dynamic disorders and morphological changes in the organ.In Chagas' cardiomyopathy, the velocity of impulse propagation diminishes in the auricular and ventricular musculature, altering the activation mechanism, this being shown by changes in the P-wave and in ventricular focal blocks.The functional refractory period (FRP) is shortened in the auricular and ventricular tissue and constitutes, together with changes in conductivity, the physiopathological basis that explains the circus movement-the fundamental factor of the arrhythmias of this stage of the disease."}