PubMed:492812 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":137},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":138,"end":271},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":272,"end":412},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":413,"end":574},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":575,"end":718},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":719,"end":883},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":137},"obj":"Sentence"},{"id":"T2","span":{"begin":138,"end":271},"obj":"Sentence"},{"id":"T3","span":{"begin":272,"end":412},"obj":"Sentence"},{"id":"T4","span":{"begin":413,"end":574},"obj":"Sentence"},{"id":"T5","span":{"begin":575,"end":718},"obj":"Sentence"},{"id":"T6","span":{"begin":719,"end":883},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":24,"end":34},"obj":"HP:0001287"},{"id":"AB1","span":{"begin":194,"end":204},"obj":"HP:0001287"},{"id":"AB2","span":{"begin":303,"end":334},"obj":"HP:0005430"},{"id":"AB3","span":{"begin":791,"end":822},"obj":"HP:0005430"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":417,"end":422},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":605,"end":610},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":645,"end":650},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"PubCasesORDO","denotations":[{"id":"TI1","span":{"begin":10,"end":34},"obj":"ORDO:33475"},{"id":"AB1","span":{"begin":180,"end":204},"obj":"ORDO:33475"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":417,"end":422},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":605,"end":610},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":645,"end":650},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":10,"end":34},"obj":"SpecificDisease:D008585"},{"id":"T2","span":{"begin":40,"end":84},"obj":"SpecificDisease:OMIM:612446"},{"id":"T3","span":{"begin":180,"end":204},"obj":"SpecificDisease:D008585"},{"id":"T4","span":{"begin":209,"end":253},"obj":"SpecificDisease:OMIM:612446"},{"id":"T5","span":{"begin":313,"end":334},"obj":"SpecificDisease:D016870"},{"id":"T6","span":{"begin":338,"end":351},"obj":"SpecificDisease:OMIM:612446"},{"id":"T7","span":{"begin":592,"end":604},"obj":"Modifier:OMIM:612446"},{"id":"T8","span":{"begin":801,"end":822},"obj":"SpecificDisease:D016870"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBI-Disease-Train","denotations":[{"id":"T4078","span":{"begin":10,"end":34},"obj":"SpecificDisease"},{"id":"T4079","span":{"begin":40,"end":84},"obj":"SpecificDisease"},{"id":"T4080","span":{"begin":180,"end":204},"obj":"SpecificDisease"},{"id":"T4081","span":{"begin":209,"end":253},"obj":"SpecificDisease"},{"id":"T4082","span":{"begin":313,"end":334},"obj":"SpecificDisease"},{"id":"T4083","span":{"begin":338,"end":351},"obj":"SpecificDisease"},{"id":"T4084","span":{"begin":592,"end":604},"obj":"Modifier"},{"id":"T4085","span":{"begin":801,"end":822},"obj":"SpecificDisease"}],"attributes":[{"id":"A4078","pred":"database_id","subj":"T4078","obj":"D008585"},{"id":"A4079","pred":"database_id","subj":"T4079","obj":"OMIM:612446"},{"id":"A4080","pred":"database_id","subj":"T4080","obj":"D008585"},{"id":"A4081","pred":"database_id","subj":"T4081","obj":"OMIM:612446"},{"id":"A4082","pred":"database_id","subj":"T4082","obj":"D016870"},{"id":"A4083","pred":"database_id","subj":"T4083","obj":"OMIM:612446"},{"id":"A4084","pred":"database_id","subj":"T4084","obj":"OMIM:612446"},{"id":"A4085","pred":"database_id","subj":"T4085","obj":"D016870"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T4078","span":{"begin":10,"end":34},"obj":"SpecificDisease"},{"id":"T4079","span":{"begin":40,"end":84},"obj":"SpecificDisease"},{"id":"T4080","span":{"begin":180,"end":204},"obj":"SpecificDisease"},{"id":"T4081","span":{"begin":209,"end":253},"obj":"SpecificDisease"},{"id":"T4082","span":{"begin":313,"end":334},"obj":"SpecificDisease"},{"id":"T4083","span":{"begin":338,"end":351},"obj":"SpecificDisease"},{"id":"T4084","span":{"begin":592,"end":604},"obj":"Modifier"},{"id":"T4085","span":{"begin":801,"end":822},"obj":"SpecificDisease"}],"attributes":[{"id":"A4078","pred":"database_id","subj":"T4078","obj":"D008585"},{"id":"A4079","pred":"database_id","subj":"T4079","obj":"OMIM:612446"},{"id":"A4080","pred":"database_id","subj":"T4080","obj":"D008585"},{"id":"A4081","pred":"database_id","subj":"T4081","obj":"OMIM:612446"},{"id":"A4082","pred":"database_id","subj":"T4082","obj":"D016870"},{"id":"A4083","pred":"database_id","subj":"T4083","obj":"OMIM:612446"},{"id":"A4084","pred":"database_id","subj":"T4084","obj":"OMIM:612446"},{"id":"A4085","pred":"database_id","subj":"T4085","obj":"D016870"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":10,"end":34},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":180,"end":204},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":801,"end":822},"obj":"SpecificDisease"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":10,"end":34},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":180,"end":204},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":313,"end":334},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":801,"end":822},"obj":"DiseaseClass"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":10,"end":34},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":180,"end":204},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":255,"end":257},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":313,"end":334},"obj":"Modifier"},{"id":"T5","span":{"begin":338,"end":351},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":801,"end":822},"obj":"Modifier"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}

{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":10,"end":34},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":180,"end":204},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":313,"end":334},"obj":"CompositeMention"},{"id":"T4","span":{"begin":338,"end":351},"obj":"DiseaseClass"},{"id":"T5","span":{"begin":592,"end":604},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":801,"end":822},"obj":"CompositeMention"}],"text":"Recurrent meningococcal meningitis with absence of the sixth component of complement: an evaluation of underlying immunologic mechanisms.\nA 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. To explore the pathogenesis of recurrent neisserial infections in C6 deficiency, a detailed analysis of her immune competence was conducted. Her serum had normal chemotactic, opsonic, alternative complement pathway, and specific antibody activity, but lacked complement-mediated bacteriolytic activity. In addition, her C6-deficient serum was indistinguishable from normal serum in a complement-dependent assay of phagocyte bactericidal activity. Absent bacteriolysis remains the only consistent defect associated with recurrent neisserial infections and absence of one of the late-acting complement components."}