PubMed:479349 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/479349","sourcedb":"PubMed","sourceid":"479349","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/479349","text":"Renal clearance of estriol and its conjugates in normal and abnormal pregnancies.\nRenal clearance of estriol (E3), E3-3-sulfate (E3S), E3-16-glucuronide (E316G), E3-3-glucuronide (E33G), and E3-3-sulfate-16-glucuronide (E3SG) has been measured in 13 normal and 17 abnormal pregnancies between the 33rd and 40th weeks of gestation. The methodology involved a chromatographic separation on a celite column in the presence of tritiated tracers, enzymic hydrolysis of the conjugates, and measurement of the E3 moiety by a specific RIA. Preeclampsia (eight patients) was characterized by a significant decrease of renal clearance for all conjugates except E33G. In contrast to that pattern, a patient with cholestatic icterus had normal clearances except for E33G, which was reduced to less than 15% of its normal mean value. Administration of ampicillin to a pregnant woman induced an important decrease of all E3 clearances, especially for E33G which decreased to nearly 1% of its initial value; normal clearances were resumed within a week after the end of the treatment. In a small number of complicated pregnancies, E3 clearances were normal. A significant correlation between the renal clearance of E316G and that of urea and creatinine has been demonstrated.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":82,"end":330},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":331,"end":531},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":532,"end":656},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":657,"end":820},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":821,"end":1069},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1070,"end":1142},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1143,"end":1260},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"T2","span":{"begin":82,"end":330},"obj":"Sentence"},{"id":"T3","span":{"begin":331,"end":531},"obj":"Sentence"},{"id":"T4","span":{"begin":532,"end":656},"obj":"Sentence"},{"id":"T5","span":{"begin":657,"end":820},"obj":"Sentence"},{"id":"T6","span":{"begin":821,"end":1069},"obj":"Sentence"},{"id":"T7","span":{"begin":1070,"end":1142},"obj":"Sentence"},{"id":"T8","span":{"begin":1143,"end":1260},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"}]},{"project":"Preeclampsia","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":532,"end":544},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"attributes":[{"subj":"PD-Preeclampsia-B_T1","pred":"source","obj":"Preeclampsia"}]},{"project":"Preeclampsia-compare","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":532,"end":544},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"attributes":[{"subj":"PD-Preeclampsia-B_T1","pred":"source","obj":"Preeclampsia-compare"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#ec93c6","default":true},{"id":"Preeclampsia","color":"#93e0ec"},{"id":"Preeclampsia-compare","color":"#ecdd93"}]}]}}