| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-104 |
Sentence |
denotes |
Measurement, characterization, and source of somatostatin-like immunoreactivity in human amniotic fluid. |
| TextSentencer_T2 |
105-201 |
Sentence |
denotes |
Somatostatin-like immunoreactivity (SLI) is widely distributed in tissues and biological fluids. |
| TextSentencer_T3 |
202-372 |
Sentence |
denotes |
To determine whether SLI is also present in amniotic fluid, samples obtained by amniocentesis from 30 normal and 27 abnormal pregnancies were studied by radioimmunoassay. |
| TextSentencer_T4 |
373-501 |
Sentence |
denotes |
Direct incubation of [(125)I-Tyr(1)]tetradecapeptide somatostatin (SRIF) with amniotic fluid resulted in 89% tracer degradation. |
| TextSentencer_T5 |
502-584 |
Sentence |
denotes |
Damage was reduced to <5% when samples were acidified and boiled before the assay. |
| TextSentencer_T6 |
585-813 |
Sentence |
denotes |
With this technique, SLI was detectable in all normal amniotic fluid samples; the mean level at 15-20 wk of gestation (320+/-55 pg/ml, n = 15) being 4.5 times higher than the mean at 32-43 wk (70+/-12 pg/ml, n = 15) (P < 0.001). |
| TextSentencer_T7 |
814-1072 |
Sentence |
denotes |
In cases of preeclampsia (n = 6), gestational diabetes (n = 5), anencephaly (n = 1), and meningomyelocele (n = 1), SLI values were in the normal range, but in one juvenile diabetic and one patient with chronic renal failure, SLI was undetectable (<10 pg/ml). |
| TextSentencer_T8 |
1073-1284 |
Sentence |
denotes |
In a pair of monochorionic diamniotic twins, SLI levels were very different (33 and 197 pg/ml), which suggests that fetal factors are more important than materno-placental ones in determining amniotic fluid SLI. |
| TextSentencer_T9 |
1285-1358 |
Sentence |
denotes |
Serial dilutions of amniotic fluid showed parallelism with standard SRIF. |
| TextSentencer_T10 |
1359-1551 |
Sentence |
denotes |
When concentrates of pooled amniotic fluid were chromatographed on Sephadex G-25 columns, all SLI eluted in the void volume ahead of SRIF even after treatment with 8 M urea and dithiothreitol. |
| TextSentencer_T11 |
1552-1713 |
Sentence |
denotes |
This "big" SLI incubated in amniotic fluid showed 100% stability over 24 h at 37 degrees C, whereas SRIF was rapidly inactivated (t((1/2)) congruent with 7 min). |
| TextSentencer_T12 |
1714-1864 |
Sentence |
denotes |
Extracts of placenta and fetal membranes contained no SLI, but small amounts (6-20% of total amniotic fluid SLI) were found in cells from fresh fluid. |
| TextSentencer_T13 |
1865-2037 |
Sentence |
denotes |
Radioimmunoassay of SLI in extracts of seven paired cord arterial and venous plasma samples showed no arteriovenous gradient consistent with fetal origin of cord blood SLI. |
| TextSentencer_T14 |
2038-2164 |
Sentence |
denotes |
It is concluded that (a) amniotic fluid contains SLI which is of fetal origin and (b) normal levels vary with gestational age. |
| TextSentencer_T15 |
2165-2261 |
Sentence |
denotes |
The SLI has a higher molecular weight (>/=5,000) and is more stable in amniotic fluid than SRIF. |
| T1 |
0-104 |
Sentence |
denotes |
Measurement, characterization, and source of somatostatin-like immunoreactivity in human amniotic fluid. |
| T2 |
105-201 |
Sentence |
denotes |
Somatostatin-like immunoreactivity (SLI) is widely distributed in tissues and biological fluids. |
| T3 |
202-372 |
Sentence |
denotes |
To determine whether SLI is also present in amniotic fluid, samples obtained by amniocentesis from 30 normal and 27 abnormal pregnancies were studied by radioimmunoassay. |
| T4 |
373-501 |
Sentence |
denotes |
Direct incubation of [(125)I-Tyr(1)]tetradecapeptide somatostatin (SRIF) with amniotic fluid resulted in 89% tracer degradation. |
| T5 |
502-584 |
Sentence |
denotes |
Damage was reduced to <5% when samples were acidified and boiled before the assay. |
| T6 |
585-813 |
Sentence |
denotes |
With this technique, SLI was detectable in all normal amniotic fluid samples; the mean level at 15-20 wk of gestation (320+/-55 pg/ml, n = 15) being 4.5 times higher than the mean at 32-43 wk (70+/-12 pg/ml, n = 15) (P < 0.001). |
| T7 |
814-1072 |
Sentence |
denotes |
In cases of preeclampsia (n = 6), gestational diabetes (n = 5), anencephaly (n = 1), and meningomyelocele (n = 1), SLI values were in the normal range, but in one juvenile diabetic and one patient with chronic renal failure, SLI was undetectable (<10 pg/ml). |
| T8 |
1073-1284 |
Sentence |
denotes |
In a pair of monochorionic diamniotic twins, SLI levels were very different (33 and 197 pg/ml), which suggests that fetal factors are more important than materno-placental ones in determining amniotic fluid SLI. |
| T9 |
1285-1358 |
Sentence |
denotes |
Serial dilutions of amniotic fluid showed parallelism with standard SRIF. |
| T10 |
1359-1551 |
Sentence |
denotes |
When concentrates of pooled amniotic fluid were chromatographed on Sephadex G-25 columns, all SLI eluted in the void volume ahead of SRIF even after treatment with 8 M urea and dithiothreitol. |
| T11 |
1552-1713 |
Sentence |
denotes |
This "big" SLI incubated in amniotic fluid showed 100% stability over 24 h at 37 degrees C, whereas SRIF was rapidly inactivated (t((1/2)) congruent with 7 min). |
| T12 |
1714-1864 |
Sentence |
denotes |
Extracts of placenta and fetal membranes contained no SLI, but small amounts (6-20% of total amniotic fluid SLI) were found in cells from fresh fluid. |
| T13 |
1865-2037 |
Sentence |
denotes |
Radioimmunoassay of SLI in extracts of seven paired cord arterial and venous plasma samples showed no arteriovenous gradient consistent with fetal origin of cord blood SLI. |
| T14 |
2038-2164 |
Sentence |
denotes |
It is concluded that (a) amniotic fluid contains SLI which is of fetal origin and (b) normal levels vary with gestational age. |
| T15 |
2165-2261 |
Sentence |
denotes |
The SLI has a higher molecular weight (>/=5,000) and is more stable in amniotic fluid than SRIF. |
