PubMed:4028047 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":160,"end":320},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":321,"end":727},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":728,"end":918},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T2","span":{"begin":160,"end":320},"obj":"Sentence"},{"id":"T3","span":{"begin":321,"end":727},"obj":"Sentence"},{"id":"T4","span":{"begin":728,"end":918},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Synthesis of a tri- and a hepta-saccharide which contain alpha-L-fucopyranosyl groups and are part of the complex type of carbohydrate moiety of glycoproteins.\nReaction of a thioglycoside with methyl trifluoromethanesulfonate (methyl triflate) in the presence of a hydroxyl compound is an efficient glycosylation method. Thus, methyl triflate-promoted condensation of ethyl 4,6-O-benzylidene-2-deoxy-2-phthalimido-1-thio-3-O-(2,3,4-tri-O-benzyl-a lpha-L- fucopyranosyl)-beta-D-glucopyranoside with benzyl 3,4,6-tri-O-benzyl-alpha-D-mannopyranoside and with benzyl 2,4-di-O-benzyl-3,6-di-O-(3,4,6-tri-O-benzyl-alpha-D-mannopyranosyl)-alp ha-D- mannopyranoside gave a trisaccharide and a heptasaccharide derivative, respectively. The trisaccharide 1 and the heptasaccharide 2, which are parts of the complex type of glycoproteins, were obtained by removal of the protecting groups and N-acetylation. (formula: see text)."}