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PubMed:3988743 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Altered secretion and accumulation of kidney glycosphingolipids by mouse pigmentation mutants with lysosomal dysfunctions.
T2 123-276 Sentence denotes The kidney and urine glycosphingolipids of five pigmentation mutants which are known to have altered secretion of kidney lysosomal enzymes were examined.
T3 277-341 Sentence denotes Among 34 pigmentation mutants which have been studied (Novak, E.
T4 342-370 Sentence denotes K., Wieland, F., Jahreis, G.
T5 371-388 Sentence denotes P., and Swank, R.
T6 389-407 Sentence denotes T. (1980) Biochem.
T7 408-414 Sentence denotes Genet.
T8 415-541 Sentence denotes 18, 549-561) eight are known to have a 1.5- to 2.5-fold increase in kidney beta-glucuronidase in testosterone-treated females.
T9 542-775 Sentence denotes These mutants appear to have defects in lysosomal processing, and because the mutations are at separate loci, each mutant probably affects different steps in assembly and/or exocytosis of lysosomes and related subcellular organelles.
T10 776-938 Sentence denotes To test whether the neutral glycosphingolipids, galabiglycosylceramides, and globotriglycosylceramides thought to be associated with kidney lysosomes (McCluer, R.
T11 939-955 Sentence denotes H., Williams, M.
T12 956-969 Sentence denotes A., Gross, S.
T13 970-989 Sentence denotes K., and Meisler, M.
T14 990-1002 Sentence denotes H. (1981) J.
T15 1003-1008 Sentence denotes Biol.
T16 1009-1014 Sentence denotes Chem.
T17 1015-1197 Sentence denotes 256, 13112-13120) also exhibit abnormal secretion in the mutants with lysosomal enzyme abnormalities, the mutants beige-J, pale ear, light ear, pallid, and ruby eye-2-J were studied.
T18 1198-1354 Sentence denotes The kidney and urine neutral glycosphingolipids from males of each mutant and C57BL/6J control mice were analyzed by high performance liquid chromatography.
T19 1355-1506 Sentence denotes Beige-J, light ear, and pale ear showed marked increases in total kidney glycolipids; globotriglycosylceramides accounted for the bulk of the increase.
T20 1507-1652 Sentence denotes Ruby eye-2-J showed less marked but significantly increased quantities of one galabiglycosylceramide and the globotriglycosylceramides in kidney.
T21 1653-1780 Sentence denotes Pallid showed no significant increase in total kidney glycolipids but the globotriglycosylceramides appeared slightly elevated.
T22 1781-1878 Sentence denotes In terms of the decrease in total urinary glycosphingolipids, the mutants fell into 2 categories.
T23 1879-2006 Sentence denotes Beige-J, light ear, and pale ear were severely affected, whereas ruby eye-2-J and pallid were affected to a much lesser extent.
T24 2007-2162 Sentence denotes Within the most severely affected group the excretion of the globotriglycosylceramides was more severely affected than that of the galabiglycosylceramides.
T25 2163-2556 Sentence denotes The galabiglycosylceramides and globotriglycosylceramides appear to be specific markers of lysosomal membranes, but the independent behavior of these two classes of lipids during testosterone induction in normal mice and the differential effects on their secretion by different mutants indicate that they do not always exist in a characteristic ratio in a single type of subcellular organelle.
T26 2557-2712 Sentence denotes All of the mutants accumulate organelles in their kidney proximal tubules which have distinct morphological characteristics as seen by electron microscopy.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 67-72 OrganismTaxon denotes mouse NCBItxid:10088|NCBItxid:10090
T3 1293-1297 OrganismTaxon denotes mice NCBItxid:10088|NCBItxid:10095
T5 2375-2379 OrganismTaxon denotes mice NCBItxid:10088|NCBItxid:10095

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 38-44 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T2 73-85 http://purl.obolibrary.org/obo/MAT_0000159 denotes pigmentation
T3 127-133 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T4 138-143 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine
T5 171-183 http://purl.obolibrary.org/obo/MAT_0000159 denotes pigmentation
T6 237-243 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T7 286-298 http://purl.obolibrary.org/obo/MAT_0000159 denotes pigmentation
T8 483-489 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T9 909-915 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T10 1143-1146 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T11 1143-1146 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T12 1143-1146 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T13 1154-1157 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T14 1154-1157 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T15 1154-1157 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T16 1176-1179 http://purl.obolibrary.org/obo/MAT_0000140 denotes eye
T17 1202-1208 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T18 1213-1218 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine
T19 1251-1256 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T20 1370-1373 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T21 1370-1373 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T22 1370-1373 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T23 1384-1387 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T24 1384-1387 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T25 1384-1387 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T26 1421-1427 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T27 1512-1515 http://purl.obolibrary.org/obo/MAT_0000140 denotes eye
T28 1645-1651 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T29 1700-1706 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T30 1894-1897 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T31 1894-1897 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T32 1894-1897 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T33 1908-1911 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T34 1908-1911 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T35 1908-1911 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T36 1949-1952 http://purl.obolibrary.org/obo/MAT_0000140 denotes eye
T37 2607-2613 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T38 2614-2622 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 67-72 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T2 99-108 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T3 244-253 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T4 582-591 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T5 730-739 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T6 916-925 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T7 1085-1094 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T8 2254-2263 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal