PubMed:3969369 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/3969369","sourcedb":"PubMed","sourceid":"3969369","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/3969369","text":"Promotional effects of testosterone and dietary fat on prostate carcinogenesis in genetically susceptible rats.\nGermfree (GF) Lobund strain Wistar (LW) rats, fed vegetable diet L-485, have developed prostate adenocarcinomas spontaneously (10% incidence) at average age 34 months. Conventional LW rats, implanted with testosterone at age 4 months, developed a higher incidence of prostate cancer after an average interval of 14 months: 24% had developed gross tumors, and 40% when it included microscopic tumors. Preliminary results indicate that testosterone-treated LW rats that were fed the same diet, which was supplemented with corn oil up to 20% fat, developed prostate cancer after intervals of 6-12 months. Aged GF Sprague-Dawley (SD) rats have not developed prostate cancer spontaneously. Conventional SD rats fed diet L-485 and treated with testosterone developed only prostatitis. Experimental designs should consider genetic susceptibility as a basic prerequisite for studies on experimental prostate cancer.","tracks":[{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":23,"end":35},"obj":"Chemical"},{"id":"T2","span":{"begin":64,"end":78},"obj":"Disease"},{"id":"T3","span":{"begin":199,"end":223},"obj":"Disease"},{"id":"T4","span":{"begin":317,"end":329},"obj":"Chemical"},{"id":"T5","span":{"begin":379,"end":394},"obj":"Disease"},{"id":"T6","span":{"begin":459,"end":465},"obj":"Disease"},{"id":"T7","span":{"begin":504,"end":510},"obj":"Disease"},{"id":"T8","span":{"begin":546,"end":558},"obj":"Chemical"},{"id":"T9","span":{"begin":666,"end":681},"obj":"Disease"},{"id":"T10","span":{"begin":766,"end":781},"obj":"Disease"},{"id":"T11","span":{"begin":850,"end":862},"obj":"Chemical"},{"id":"T12","span":{"begin":878,"end":889},"obj":"Disease"},{"id":"T13","span":{"begin":1003,"end":1018},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bc5cdr-valid-experiment","color":"#93ecbf","default":true}]}]}}