| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-132 |
Sentence |
denotes |
Chemical extension and glycodendrimer formation of the matriglycan decasaccharide, -(3Xylα1-3GlcAβ1)5- and its affinity for laminin. |
| T2 |
133-219 |
Sentence |
denotes |
Muscle tissue is stabilized by the strong interaction between laminin and matriglycan. |
| T3 |
220-365 |
Sentence |
denotes |
Matriglycan is a polysaccharide composed of the repeating disaccharide, -3Xylα1-3GlcAβ1-, and is a pivotal part of the core M3 O-mannosyl glycan. |
| T4 |
366-543 |
Sentence |
denotes |
Patients with muscular dystrophy cannot synthesize matriglycan or the core M3 O-mannosyl glycan due to a defect in or the lack of glycosyltransferases owing to glycan synthesis. |
| T5 |
544-653 |
Sentence |
denotes |
Therefore, a supply of matriglycan may be a powerful tool for reconstructing muscle tissue in these patients. |
| T6 |
654-791 |
Sentence |
denotes |
We herein report the synthesis of a matriglycan-repeating decasaccharide and a dendrimer comprising three branches of the decasaccharide. |
| T7 |
792-912 |
Sentence |
denotes |
The glycan was regio- and stereoselectively synthesized by the stepwise addition of the corresponding disaccharide unit. |
| T8 |
913-1017 |
Sentence |
denotes |
The immobilized decasaccharide and glycodendrimer bound to laminin-G-like domains 4 and 5 of laminin-α2. |
| T9 |
1018-1311 |
Sentence |
denotes |
The dissociation constants of the decasaccharide and dendrimer obtained from bio-layer interferometry were estimated to be 4.4 × 10-8 M and 6.8 × 10-8 M, respectively, showing higher affinity than those of a matriglycan-repeating hexasaccharide (1.6 × 10-7 M) and the dendrimer (1.8 × 10-7 M). |
