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PubMed:39567616 JSONTXT

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GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1109-1112 Glycan denotes LC3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 67-73 Phenotype denotes sepsis HP:0100806
T2 187-193 Phenotype denotes sepsis HP:0100806
T3 348-354 Phenotype denotes sepsis HP:0100806
T4 370-376 Phenotype denotes sepsis HP:0100806
T5 1051-1057 Phenotype denotes sepsis HP:0100806
T6 1964-1970 Phenotype denotes sepsis HP:0100806

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes The impact of ulinastatin on lymphocyte apoptosis and autophagy in sepsis patients.
T2 84-355 Sentence denotes This study aimed to assess the influence of ulinastatin (UTI) on lymphocyte apoptosis and autophagy in sepsis patients, as well as its effect on inflammatory factors and vital organ function, with the goal of providing insights for improved clinical management of sepsis.
T3 356-447 Sentence denotes A total of 40 sepsis patients were randomly assigned to the UTI group or the control group.
T4 448-570 Sentence denotes The UTI group received standard treatment plus intravenous UTI, while the control group received standard treatment alone.
T5 571-725 Sentence denotes Peripheral blood samples were collected at multiple time points for analysis of lymphocyte apoptosis, autophagy, inflammatory markers, and organ function.
T6 726-941 Sentence denotes Various experimental techniques including Hoechst staining, transmission electron microscopy, and Western blot analysis were utilized to assess lymphocyte apoptosis, autophagy, and related protein expression levels.
T7 942-1067 Sentence denotes The study revealed that UTI treatment significantly inhibited lymphocyte apoptosis and promoted autophagy in sepsis patients.
T8 1068-1257 Sentence denotes The levels of autophagy-related proteins LC3-II and Beclin-1 were substantially elevated, while the ratio of anti-apoptotic Bcl-2 to pro-apoptotic Bax was increased following UTI treatment.
T9 1258-1419 Sentence denotes Furthermore, the levels of inflammatory markers IL-6, procalcitonin, and C-reactive protein were markedly reduced in the UTI group compared to the control group.
T10 1420-1583 Sentence denotes Additionally, UTI treatment led to improved liver, kidney and cardiac function as evidenced by reduced levels of liver enzymes and creatinine, and cardiac enzymes.
T11 1584-1773 Sentence denotes The findings of this study demonstrate that UTI exerts a protective effect on septic patients by inhibiting lymphocyte apoptosis, promoting autophagy, and attenuating systemic inflammation.
T12 1774-1882 Sentence denotes Moreover, UTI treatment was associated with improved liver, kidney, and cardiac function in septic patients.
T13 1883-2056 Sentence denotes These results contribute to a better understanding of the clinical management of sepsis and underscore the potential of UTI as a therapeutic intervention in septic patients.

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 74-82 Organism denotes patients 9606
T2 194-202 Organism denotes patients 9606
T3 377-385 Organism denotes patients 9606
T4 1058-1066 Organism denotes patients 9606
T5 1669-1677 Organism denotes patients 9606
T6 1873-1881 Organism denotes patients 9606
T7 2047-2055 Organism denotes patients 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 29-39 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T2 149-159 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T3 260-265 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T5 582-587 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 651-661 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T7 710-715 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T9 870-880 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T10 1004-1014 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T11 1464-1469 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T12 1471-1477 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T13 1533-1538 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T14 1692-1702 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T15 1827-1832 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T16 1834-1840 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 29-39 Body_part denotes lymphocyte FMA:62863
T2 149-159 Body_part denotes lymphocyte FMA:62863
T3 260-265 Body_part denotes organ FMA:67498
T4 582-587 Body_part denotes blood FMA:9670
T5 651-661 Body_part denotes lymphocyte FMA:62863
T6 710-715 Body_part denotes organ FMA:67498
T7 870-880 Body_part denotes lymphocyte FMA:62863
T8 1004-1014 Body_part denotes lymphocyte FMA:62863
T9 1464-1469 Body_part denotes liver FMA:7197
T10 1471-1477 Body_part denotes kidney FMA:7203
T11 1533-1538 Body_part denotes liver FMA:7197
T12 1692-1702 Body_part denotes lymphocyte FMA:62863
T13 1827-1832 Body_part denotes liver FMA:7197
T14 1834-1840 Body_part denotes kidney FMA:7203

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 582-587 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000315
T2 1464-1469 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 1471-1477 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T4 1533-1538 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T5 1827-1832 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T6 1834-1840 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119