PubMed:3955572 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/3955572","sourcedb":"PubMed","sourceid":"3955572","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/3955572","text":"Cyclic platelet-activating factor analogues derived from 2-deoxy-D-erythro-pentose.\nA method for the synthesis of chiral cyclic analogues of platelet-activating factor (PAF) is reported. Treatment of suitably substituted derivatives of 2-deoxy-D-erythro-pentose with phosphorus oxychloride, followed by choline p-toluenesulfonate generates cyclic phospholipids in good yield. Further chemical modification produces other compounds including optically active gamma-butyrolactones such as 2-deoxy-5-O-hexadecyl-3-O-phosphocholyl-D-erythro-pentono-1, 4-lactone and 2-deoxy-3-O-hexadecyl-5-O-phosphocholyl-D-erythro-pentono-1, 4-lactone. All phospholipids were poor antagonists of PAF-induced aggregation of human platelets, and two analogs were poor agonists. The chemistry presented should be useful for the syntheses of other conformationally restricted analogues of PAF.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":84,"end":186},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":187,"end":375},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":376,"end":633},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":634,"end":756},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":757,"end":870},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":186},"obj":"Sentence"},{"id":"T3","span":{"begin":187,"end":375},"obj":"Sentence"},{"id":"T4","span":{"begin":376,"end":633},"obj":"Sentence"},{"id":"T5","span":{"begin":634,"end":756},"obj":"Sentence"},{"id":"T6","span":{"begin":757,"end":870},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":704,"end":709},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":7,"end":15},"obj":"Body_part"},{"id":"T2","span":{"begin":141,"end":149},"obj":"Body_part"},{"id":"T3","span":{"begin":710,"end":719},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000233"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000233"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000233"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":7,"end":15},"obj":"Cell"},{"id":"T2","span":{"begin":141,"end":149},"obj":"Cell"},{"id":"T3","span":{"begin":710,"end":719},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000233"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000233"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000233"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#9cec93","default":true},{"id":"NCBITAXON","color":"#ec93b7"},{"id":"Anatomy-UBERON","color":"#93d1ec"},{"id":"CL-cell","color":"#ebec93"}]}]}}