PubMed:3933563
Annnotations
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 271-279 | Glycan | denotes | F1 alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G61730RY |
| T2 | 628-636 | Glycan | denotes | F1 alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G61730RY |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 271-279 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | F1 alpha | http://www.glycoepitope.jp/epitopes/EP0024 |
| T2 | 628-636 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | F1 alpha | http://www.glycoepitope.jp/epitopes/EP0024 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 271-279 | Glycan | denotes | F1 alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G61730RY |
| T2 | 628-636 | Glycan | denotes | F1 alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G61730RY |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 24-45 | Cell | denotes | peritoneal macrophage | http://purl.obolibrary.org/obo/CL:0000581 |
| T2 | 35-45 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T4 | 216-221 | Cell | denotes | basal | http://purl.obolibrary.org/obo/CL:0002324 |
| T5 | 327-329 | Cell | denotes | I2 | http://purl.obolibrary.org/obo/CL:0004120 |
| T6 | 411-433 | Cell | denotes | peritoneal macrophages | http://purl.obolibrary.org/obo/CL:0000581 |
| T7 | 1344-1355 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T9 | 1424-1429 | Cell | denotes | basal | http://purl.obolibrary.org/obo/CL:0002324 |
| T10 | 1649-1660 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T12 | 1996-2001 | Cell | denotes | basal | http://purl.obolibrary.org/obo/CL:0002324 |
| T13 | 2094-2105 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 35-45 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 422-433 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T3 | 1344-1355 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 1649-1660 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T5 | 2094-2105 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 20-23 | Organism | denotes | rat | 10114|10116 |
| T3 | 407-410 | Organism | denotes | rat | 10114|10116 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-130 | Sentence | denotes | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. |
| T2 | 131-434 | Sentence | denotes | Altering the buffer K+/Na+ ratio ([K+]o/[Na+]o) resulted in a biphasic change in the basal release of prostaglandin E2, 6-ketoprostaglandin F1 alpha (the stable breakdown product of prostaglandin I2) and thromboxane B2 (the stable metabolite of thromboxane A2), from resident rat peritoneal macrophages. |
| T3 | 435-664 | Sentence | denotes | Changing the [K+]o (at the expense of [Na+]o) from 15 mM to 0 mM or 75 mM (combined concentration of [K+]o and [Na+]o was maintained at 150 mM) resulted in a stimulation of 6-ketoprostaglandin F1 alpha and thromboxane B2 release. |
| T4 | 665-760 | Sentence | denotes | Prostaglandin E2 synthesis was also stimulated when the [K+]o was decreased from 15 mM to 0 mM. |
| T5 | 761-931 | Sentence | denotes | When the [K+]o was increased to 45 mM, prostaglandin E2 formation was inhibited but returned to values observed at 15 mM K+ when the [K+]o was further increased to 75 mM. |
| T6 | 932-1037 | Sentence | denotes | Prostaglandin E2 synthesis at 75 mM K+ was still only 40% of that measured in the absence of K+, however. |
| T7 | 1038-1252 | Sentence | denotes | When cells were incubated in a Ca2+-free medium (+EDTA) eicosanoid release was drastically reduced and the changes in arachidonic acid metabolite release observed on changing the buffer [K+]o/[Na+]o were abolished. |
| T8 | 1253-1553 | Sentence | denotes | Total release of radiolabel ([14C]arachidonic acid and its radiolabelled metabolites) from macrophages prelabelled with [14C]arachidonic acid followed the same pattern as basal eicosanoid release, suggesting that changing [K+]o influenced phospholipase A2 activity, and hence, substrate availability. |
| T9 | 1554-1715 | Sentence | denotes | At all [K+]o values, from 0 mM to 75 mM, cicletanide reduced the release of radioactivity from macrophages prelabelled with [14C]arachidonic acid (by about 15%). |
| T10 | 1716-1941 | Sentence | denotes | In the presence of [K+]o, cicletanide had a stimulatory effect on the metabolism of the free fatty acid which masked the decrease in eicosanoid release expected due to inhibition of arachidonic acid release from phospholipid. |
| T11 | 1942-2280 | Sentence | denotes | In the presence of 5 mM K+, cicletanide inhibited the basal release but enhanced the arachidonic acid-stimulated synthesis of eicosanoids from resident macrophages in a dose-related fashion, confirming the dual action of the drug, i.e., the inhibitory effect on arachidonic acid release and the stimulation of arachidonic acid metabolism. |
| T12 | 2281-2345 | Sentence | denotes | The possible in vivo significance of these results is discussed. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 271-279 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | F1 alpha | http://www.glycoepitope.jp/epitopes/EP0024 |
| T2 | 628-636 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | F1 alpha | http://www.glycoepitope.jp/epitopes/EP0024 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 24-45 | Body_part | denotes | peritoneal macrophage | FMA:83025 |
| T2 | 411-433 | Body_part | denotes | peritoneal macrophages | FMA:83025 |
| T3 | 1344-1355 | Body_part | denotes | macrophages | FMA:63261 |
| T4 | 1649-1660 | Body_part | denotes | macrophages | FMA:63261 |
| T5 | 2094-2105 | Body_part | denotes | macrophages | FMA:63261 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 20-23 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 407-410 | OrganismTaxon | denotes | rat | 10114|10116 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 35-45 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 422-433 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T3 | 1344-1355 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 1649-1660 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T5 | 2094-2105 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 24-45 | Cell | denotes | peritoneal macrophage | http://purl.obolibrary.org/obo/CL:0000581 |
| T2 | 35-45 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T4 | 216-221 | Cell | denotes | basal | http://purl.obolibrary.org/obo/CL:0002324 |
| T5 | 327-329 | Cell | denotes | I2 | http://purl.obolibrary.org/obo/CL:0004120 |
| T6 | 411-433 | Cell | denotes | peritoneal macrophages | http://purl.obolibrary.org/obo/CL:0000581 |
| T7 | 1344-1355 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T9 | 1424-1429 | Cell | denotes | basal | http://purl.obolibrary.org/obo/CL:0002324 |
| T10 | 1649-1660 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T12 | 1996-2001 | Cell | denotes | basal | http://purl.obolibrary.org/obo/CL:0002324 |
| T13 | 2094-2105 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |