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injection manufactured by a hospital pharmacy.\nA method used by a hospital pharmacy department for manufacturing and testing a ready-to-administer i.v. nitroglycerin injection is described, and costs for this extemporaneously prepared injection are compared with costs for commercially available nitroglycerin products for i.v. use. A powder adsorbate containing one part nitroglycerin and nine parts lactose was used to prepare nitroglycerin injection in two strengths: 0.04 mg/mL (250-mL quantities) in 0.9% sodium chloride injection and 0.4 mg/mL (400-mL quantities) in 5% dextrose injection. Each batch was tested for sterility, for presence of pyrogens (endotoxin testing), and for nitroglycerin concentration (spectrophotometric assay). In one year, a total of 1217 bottles of nitroglycerin injection were prepared. This required 75 hours; preparation from commercial i.v. nitroglycerin products would have required approximately 200 hours (including admixture preparation). First-year costs for extemporaneous preparation (excluding costs of i.v. solutions and containers) were approximately $2200, far less than drug costs alone for the commercial i.v. nitroglycerin products. Nitroglycerin injection of high quality and confirmed potency was prepared extemporaneously in a hospital pharmacy department. Costs for this method were substantially less than those for use of commercial i.v. nitroglycerin products."}

{"project":"oger-json-test","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"D005996"},{"id":"T2","span":{"begin":0,"end":13},"obj":"CHEBI:28787"},{"id":"T3","span":{"begin":166,"end":179},"obj":"D005996"},{"id":"T4","span":{"begin":166,"end":179},"obj":"CHEBI:28787"},{"id":"T5","span":{"begin":310,"end":323},"obj":"D005996"},{"id":"T6","span":{"begin":310,"end":323},"obj":"CHEBI:28787"},{"id":"T7","span":{"begin":333,"end":338},"obj":"PR:000001053"},{"id":"T8","span":{"begin":386,"end":399},"obj":"D005996"},{"id":"T9","span":{"begin":386,"end":399},"obj":"CHEBI:28787"},{"id":"T10","span":{"begin":415,"end":422},"obj":"CHEBI:36219"},{"id":"T11","span":{"begin":415,"end":422},"obj":"D007785"},{"id":"T12","span":{"begin":415,"end":422},"obj":"CHEBI:17716"},{"id":"T13","span":{"begin":415,"end":422},"obj":"CHEBI:36218"},{"id":"T14","span":{"begin":443,"end":456},"obj":"D005996"},{"id":"T15","span":{"begin":443,"end":456},"obj":"CHEBI:28787"},{"id":"T16","span":{"begin":524,"end":530},"obj":"CHEBI:26708"},{"id":"T17","span":{"begin":524,"end":539},"obj":"CHEBI:26710"},{"id":"T18","span":{"begin":524,"end":539},"obj":"D012965"},{"id":"T19","span":{"begin":531,"end":539},"obj":"CHEBI:17996"},{"id":"T20","span":{"begin":590,"end":598},"obj":"D005947"},{"id":"T21","span":{"begin":590,"end":598},"obj":"CHEBI:17634"},{"id":"T22","span":{"begin":590,"end":598},"obj":"CHEBI:4167"},{"id":"T23","span":{"begin":590,"end":598},"obj":"CHEBI:42758"},{"id":"T24","span":{"begin":636,"end":645},"obj":"D007246"},{"id":"T25","span":{"begin":663,"end":671},"obj":"D011749"},{"id":"T26","span":{"begin":673,"end":682},"obj":"CHEBI:89981"},{"id":"T27","span":{"begin":701,"end":714},"obj":"D005996"},{"id":"T28","span":{"begin":701,"end":714},"obj":"CHEBI:28787"},{"id":"T29","span":{"begin":797,"end":810},"obj":"D005996"},{"id":"T30","span":{"begin":797,"end":810},"obj":"CHEBI:28787"},{"id":"T31","span":{"begin":893,"end":906},"obj":"D005996"},{"id":"T32","span":{"begin":893,"end":906},"obj":"CHEBI:28787"},{"id":"T33","span":{"begin":1120,"end":1123},"obj":"PR:000022738"},{"id":"T34","span":{"begin":1134,"end":1138},"obj":"CHEBI:23888"},{"id":"T35","span":{"begin":1175,"end":1188},"obj":"D005996"},{"id":"T36","span":{"begin":1175,"end":1188},"obj":"CHEBI:28787"},{"id":"T37","span":{"begin":1199,"end":1212},"obj":"D005996"},{"id":"T38","span":{"begin":1199,"end":1212},"obj":"CHEBI:28787"},{"id":"T39","span":{"begin":1410,"end":1423},"obj":"D005996"},{"id":"T40","span":{"begin":1410,"end":1423},"obj":"CHEBI:28787"}],"text":"Nitroglycerin injection manufactured by a hospital pharmacy.\nA method used by a hospital pharmacy department for manufacturing and testing a ready-to-administer i.v. nitroglycerin injection is described, and costs for this extemporaneously prepared injection are compared with costs for commercially available nitroglycerin products for i.v. use. A powder adsorbate containing one part nitroglycerin and nine parts lactose was used to prepare nitroglycerin injection in two strengths: 0.04 mg/mL (250-mL quantities) in 0.9% sodium chloride injection and 0.4 mg/mL (400-mL quantities) in 5% dextrose injection. Each batch was tested for sterility, for presence of pyrogens (endotoxin testing), and for nitroglycerin concentration (spectrophotometric assay). In one year, a total of 1217 bottles of nitroglycerin injection were prepared. This required 75 hours; preparation from commercial i.v. nitroglycerin products would have required approximately 200 hours (including admixture preparation). First-year costs for extemporaneous preparation (excluding costs of i.v. solutions and containers) were approximately $2200, far less than drug costs alone for the commercial i.v. nitroglycerin products. Nitroglycerin injection of high quality and confirmed potency was prepared extemporaneously in a hospital pharmacy department. Costs for this method were substantially less than those for use of commercial i.v. nitroglycerin products."}