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skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma.\nSixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Conversely, a long-term CR occurred in only one of five patients with tumor-phase intracutaneous CTCL (Stage IIB) and in none of the 5 patients with histopathologically proven nodal involvement (Stage IVA). Radiotherapy was well tolerated with the major toxicity being bone marrow suppression. We conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment."}

{"project":"oger-json-test","denotations":[{"id":"T1","span":{"begin":11,"end":19},"obj":"CHEBI:10545"},{"id":"T2","span":{"begin":35,"end":40},"obj":"PR:000000105"},{"id":"T3","span":{"begin":35,"end":40},"obj":"P43021"},{"id":"T4","span":{"begin":84,"end":109},"obj":"D016410"},{"id":"T5","span":{"begin":94,"end":100},"obj":"CL:0000084"},{"id":"T6","span":{"begin":94,"end":109},"obj":"D016399"},{"id":"T7","span":{"begin":96,"end":100},"obj":"GO:0005623"},{"id":"T8","span":{"begin":96,"end":100},"obj":"CL:0000000"},{"id":"T9","span":{"begin":101,"end":109},"obj":"D008223"},{"id":"T10","span":{"begin":142,"end":167},"obj":"D016410"},{"id":"T11","span":{"begin":152,"end":158},"obj":"CL:0000084"},{"id":"T12","span":{"begin":152,"end":167},"obj":"D016399"},{"id":"T13","span":{"begin":154,"end":158},"obj":"GO:0005623"},{"id":"T14","span":{"begin":154,"end":158},"obj":"CL:0000000"},{"id":"T15","span":{"begin":159,"end":167},"obj":"D008223"},{"id":"T16","span":{"begin":312,"end":320},"obj":"CHEBI:10545"},{"id":"T17","span":{"begin":351,"end":356},"obj":"PR:000000105"},{"id":"T18","span":{"begin":351,"end":356},"obj":"P43021"},{"id":"T19","span":{"begin":370,"end":373},"obj":"Q7M3Y3"},{"id":"T20","span":{"begin":370,"end":373},"obj":"P05547"},{"id":"T21","span":{"begin":370,"end":373},"obj":"PR:P36188"},{"id":"T22","span":{"begin":370,"end":373},"obj":"PR:P23693"},{"id":"T23","span":{"begin":721,"end":725},"obj":"original_id"},{"id":"T24","span":{"begin":772,"end":777},"obj":"D009369"},{"id":"T25","span":{"begin":823,"end":827},"obj":"32644"},{"id":"T26","span":{"begin":878,"end":883},"obj":"PR:000000105"},{"id":"T27","span":{"begin":878,"end":883},"obj":"P43021"},{"id":"T28","span":{"begin":903,"end":906},"obj":"C538167"},{"id":"T29","span":{"begin":1031,"end":1034},"obj":"Q7M3Y3"},{"id":"T30","span":{"begin":1031,"end":1034},"obj":"P05547"},{"id":"T31","span":{"begin":1031,"end":1034},"obj":"PR:P36188"},{"id":"T32","span":{"begin":1031,"end":1034},"obj":"PR:P23693"},{"id":"T33","span":{"begin":1116,"end":1127},"obj":"GO:0032502"},{"id":"T34","span":{"begin":1160,"end":1164},"obj":"original_id"}],"text":"Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma.\nSixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Conversely, a long-term CR occurred in only one of five patients with tumor-phase intracutaneous CTCL (Stage IIB) and in none of the 5 patients with histopathologically proven nodal involvement (Stage IVA). Radiotherapy was well tolerated with the major toxicity being bone marrow suppression. We conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment."}