PubMed:3921233 JSONTXT

{"project":"spacy-test","denotations":[{"id":"spaCy_T0","span":{"begin":0,"end":10},"obj":"NNP"},{"id":"spaCy_T1","span":{"begin":11,"end":30},"obj":"JJ"},{"id":"spaCy_T2","span":{"begin":31,"end":36},"obj":"JJ"},{"id":"spaCy_T3","span":{"begin":37,"end":45},"obj":"NN"},{"id":"spaCy_T4","span":{"begin":46,"end":57},"obj":"NN"},{"id":"spaCy_T5","span":{"begin":58,"end":66},"obj":"NN"},{"id":"spaCy_T6","span":{"begin":66,"end":67},"obj":":"},{"id":"spaCy_T7","span":{"begin":68,"end":78},"obj":"NN"},{"id":"spaCy_T8","span":{"begin":79,"end":81},"obj":"IN"},{"id":"spaCy_T9","span":{"begin":82,"end":85},"obj":"DT"},{"id":"spaCy_T10","span":{"begin":86,"end":94},"obj":"NN"},{"id":"spaCy_T11","span":{"begin":95,"end":97},"obj":"IN"},{"id":"spaCy_T12","span":{"begin":98,"end":114},"obj":"NN"},{"id":"spaCy_T13","span":{"begin":114,"end":115},"obj":"."},{"id":"spaCy_T14","span":{"begin":116,"end":124},"obj":"RB"},{"id":"spaCy_T15","span":{"begin":124,"end":125},"obj":","},{"id":"spaCy_T16","span":{"begin":126,"end":142},"obj":"NN"},{"id":"spaCy_T17","span":{"begin":143,"end":144},"obj":"-LRB-"},{"id":"spaCy_T18","span":{"begin":144,"end":153},"obj":"NNP"},{"id":"spaCy_T19","span":{"begin":153,"end":154},"obj":"-RRB-"},{"id":"spaCy_T20","span":{"begin":155,"end":158},"obj":"VBZ"},{"id":"spaCy_T21","span":{"begin":159,"end":163},"obj":"VBN"},{"id":"spaCy_T22","span":{"begin":164,"end":169},"obj":"VBN"},{"id":"spaCy_T23","span":{"begin":170,"end":172},"obj":"TO"},{"id":"spaCy_T24","span":{"begin":173,"end":175},"obj":"VB"},{"id":"spaCy_T25","span":{"begin":176,"end":180},"obj":"VB"},{"id":"spaCy_T26","span":{"begin":181,"end":184},"obj":"DT"},{"id":"spaCy_T27","span":{"begin":185,"end":193},"obj":"NN"},{"id":"spaCy_T28","span":{"begin":194,"end":196},"obj":"TO"},{"id":"spaCy_T29","span":{"begin":197,"end":205},"obj":"VB"},{"id":"spaCy_T30","span":{"begin":206,"end":217},"obj":"NNS"},{"id":"spaCy_T31","span":{"begin":218,"end":220},"obj":"IN"},{"id":"spaCy_T32","span":{"begin":221,"end":228},"obj":"JJ"},{"id":"spaCy_T33","span":{"begin":229,"end":235},"obj":"NN"},{"id":"spaCy_T34","span":{"begin":236,"end":239},"obj":"CC"},{"id":"spaCy_T35","span":{"begin":240,"end":245},"obj":"JJ"},{"id":"spaCy_T36","span":{"begin":246,"end":253},"obj":"NNS"},{"id":"spaCy_T37","span":{"begin":253,"end":254},"obj":"."},{"id":"spaCy_T38","span":{"begin":255,"end":258},"obj":"DT"},{"id":"spaCy_T39","span":{"begin":259,"end":266},"obj":"NNS"},{"id":"spaCy_T40","span":{"begin":267,"end":275},"obj":"VBD"},{"id":"spaCy_T41","span":{"begin":276,"end":280},"obj":"RB"},{"id":"spaCy_T42","span":{"begin":281,"end":285},"obj":"VBD"},{"id":"spaCy_T43","span":{"begin":286,"end":296},"obj":"VBN"},{"id":"spaCy_T44","span":{"begin":297,"end":299},"obj":"TO"},{"id":"spaCy_T45","span":{"begin":300,"end":309},"obj":"VB"},{"id":"spaCy_T46","span":{"begin":310,"end":313},"obj":"DT"},{"id":"spaCy_T47","span":{"begin":314,"end":322},"obj":"NN"},{"id":"spaCy_T48","span":{"begin":323,"end":325},"obj":"IN"},{"id":"spaCy_T49","span":{"begin":326,"end":329},"obj":"DT"},{"id":"spaCy_T50","span":{"begin":330,"end":340},"obj":"NN"},{"id":"spaCy_T51","span":{"begin":341,"end":352},"obj":"JJ"},{"id":"spaCy_T52","span":{"begin":353,"end":356},"obj":"IN"},{"id":"spaCy_T53","span":{"begin":357,"end":367},"obj":"NN"},{"id":"spaCy_T54","span":{"begin":368,"end":370},"obj":"IN"},{"id":"spaCy_T55","span":{"begin":371,"end":376},"obj":"JJ"},{"id":"spaCy_T56","span":{"begin":377,"end":386},"obj":"NNS"},{"id":"spaCy_T57","span":{"begin":387,"end":389},"obj":"TO"},{"id":"spaCy_T58","span":{"begin":390,"end":391},"obj":"DT"},{"id":"spaCy_T59","span":{"begin":392,"end":403},"obj":"JJ"},{"id":"spaCy_T60","span":{"begin":404,"end":409},"obj":"NN"},{"id":"spaCy_T61","span":{"begin":409,"end":410},"obj":"."},{"id":"spaCy_T62","span":{"begin":411,"end":432},"obj":"JJ"},{"id":"spaCy_T63","span":{"begin":433,"end":439},"obj":"NN"},{"id":"spaCy_T64","span":{"begin":440,"end":441},"obj":"-LRB-"},{"id":"spaCy_T65","span":{"begin":441,"end":444},"obj":"NNP"},{"id":"spaCy_T66","span":{"begin":444,"end":445},"obj":"-RRB-"},{"id":"spaCy_T67","span":{"begin":446,"end":454},"obj":"NN"},{"id":"spaCy_T68","span":{"begin":455,"end":458},"obj":"VBD"},{"id":"spaCy_T69","span":{"begin":459,"end":467},"obj":"VBN"},{"id":"spaCy_T70","span":{"begin":468,"end":473},"obj":"VBG"},{"id":"spaCy_T71","span":{"begin":474,"end":475},"obj":"DT"},{"id":"spaCy_T72","span":{"begin":476,"end":480},"obj":"JJ"},{"id":"spaCy_T73","span":{"begin":481,"end":485},"obj":"JJ"},{"id":"spaCy_T74","span":{"begin":486,"end":493},"obj":"NN"},{"id":"spaCy_T75","span":{"begin":494,"end":499},"obj":"NN"},{"id":"spaCy_T76","span":{"begin":500,"end":504},"obj":"IN"},{"id":"spaCy_T77","span":{"begin":505,"end":510},"obj":"JJ"},{"id":"spaCy_T78","span":{"begin":511,"end":520},"obj":"NNS"},{"id":"spaCy_T79","span":{"begin":521,"end":523},"obj":"IN"},{"id":"spaCy_T80","span":{"begin":524,"end":532},"obj":"NN"},{"id":"spaCy_T81","span":{"begin":533,"end":538},"obj":"NNS"},{"id":"spaCy_T82","span":{"begin":539,"end":542},"obj":"CC"},{"id":"spaCy_T83","span":{"begin":543,"end":548},"obj":"NN"},{"id":"spaCy_T84","span":{"begin":549,"end":556},"obj":"NNS"},{"id":"spaCy_T85","span":{"begin":556,"end":557},"obj":"."},{"id":"spaCy_T86","span":{"begin":558,"end":568},"obj":"VBN"},{"id":"spaCy_T87","span":{"begin":569,"end":579},"obj":"NN"},{"id":"spaCy_T88","span":{"begin":580,"end":592},"obj":"NNS"},{"id":"spaCy_T89","span":{"begin":593,"end":597},"obj":"VBD"},{"id":"spaCy_T90","span":{"begin":598,"end":606},"obj":"VBN"},{"id":"spaCy_T91","span":{"begin":607,"end":609},"obj":"IN"},{"id":"spaCy_T92","span":{"begin":610,"end":621},"obj":"NN"},{"id":"spaCy_T93","span":{"begin":622,"end":624},"obj":"IN"},{"id":"spaCy_T94","span":{"begin":625,"end":635},"obj":"JJ"},{"id":"spaCy_T95","span":{"begin":636,"end":641},"obj":"NN"},{"id":"spaCy_T96","span":{"begin":642,"end":653},"obj":"NN"},{"id":"spaCy_T97","span":{"begin":654,"end":659},"obj":"NNS"},{"id":"spaCy_T98","span":{"begin":660,"end":664},"obj":"IN"},{"id":"spaCy_T99","span":{"begin":665,"end":677},"obj":"NN"},{"id":"spaCy_T100","span":{"begin":678,"end":679},"obj":"DT"},{"id":"spaCy_T101","span":{"begin":680,"end":682},"obj":"IN"},{"id":"spaCy_T102","span":{"begin":683,"end":693},"obj":"JJ"},{"id":"spaCy_T103","span":{"begin":694,"end":699},"obj":"NNS"},{"id":"spaCy_T104","span":{"begin":699,"end":700},"obj":"."},{"id":"spaCy_T105","span":{"begin":701,"end":711},"obj":"NNP"},{"id":"spaCy_T106","span":{"begin":712,"end":715},"obj":"VBD"},{"id":"spaCy_T107","span":{"begin":716,"end":724},"obj":"VBN"},{"id":"spaCy_T108","span":{"begin":725,"end":727},"obj":"IN"},{"id":"spaCy_T109","span":{"begin":728,"end":730},"obj":"DT"},{"id":"spaCy_T110","span":{"begin":731,"end":740},"obj":"JJ"},{"id":"spaCy_T111","span":{"begin":741,"end":746},"obj":"NN"},{"id":"spaCy_T112","span":{"begin":746,"end":747},"obj":"."},{"id":"spaCy_T113","span":{"begin":748,"end":752},"obj":"CD"},{"id":"spaCy_T114","span":{"begin":753,"end":758},"obj":"NNS"},{"id":"spaCy_T115","span":{"begin":759,"end":761},"obj":"IN"},{"id":"spaCy_T116","span":{"begin":762,"end":770},"obj":"NN"},{"id":"spaCy_T117","span":{"begin":771,"end":775},"obj":"NN"},{"id":"spaCy_T118","span":{"begin":776,"end":778},"obj":"TO"},{"id":"spaCy_T119","span":{"begin":779,"end":782},"obj":"DT"},{"id":"spaCy_T120","span":{"begin":783,"end":793},"obj":"NN"},{"id":"spaCy_T121","span":{"begin":794,"end":798},"obj":"WDT"},{"id":"spaCy_T122","span":{"begin":799,"end":802},"obj":"NNP"},{"id":"spaCy_T123","span":{"begin":803,"end":806},"obj":"CC"},{"id":"spaCy_T124","span":{"begin":807,"end":816},"obj":"NNP"},{"id":"spaCy_T125","span":{"begin":817,"end":820},"obj":"VBP"},{"id":"spaCy_T126","span":{"begin":821,"end":830},"obj":"JJ"},{"id":"spaCy_T127","span":{"begin":831,"end":833},"obj":"IN"},{"id":"spaCy_T128","span":{"begin":834,"end":838},"obj":"DT"},{"id":"spaCy_T129","span":{"begin":839,"end":845},"obj":"NN"},{"id":"spaCy_T130","span":{"begin":845,"end":846},"obj":":"},{"id":"spaCy_T131","span":{"begin":847,"end":848},"obj":"-LRB-"},{"id":"spaCy_T132","span":{"begin":848,"end":849},"obj":"DT"},{"id":"spaCy_T133","span":{"begin":849,"end":850},"obj":"-RRB-"},{"id":"spaCy_T134","span":{"begin":851,"end":864},"obj":"NN"},{"id":"spaCy_T135","span":{"begin":865,"end":867},"obj":"IN"},{"id":"spaCy_T136","span":{"begin":868,"end":878},"obj":"VBN"},{"id":"spaCy_T137","span":{"begin":879,"end":889},"obj":"NN"},{"id":"spaCy_T138","span":{"begin":890,"end":902},"obj":"NNS"},{"id":"spaCy_T139","span":{"begin":903,"end":905},"obj":"IN"},{"id":"spaCy_T140","span":{"begin":906,"end":916},"obj":"NN"},{"id":"spaCy_T141","span":{"begin":917,"end":931},"obj":"NN"},{"id":"spaCy_T142","span":{"begin":931,"end":932},"obj":","},{"id":"spaCy_T143","span":{"begin":933,"end":941},"obj":"VBN"},{"id":"spaCy_T144","span":{"begin":942,"end":944},"obj":"IN"},{"id":"spaCy_T145","span":{"begin":945,"end":950},"obj":"NN"},{"id":"spaCy_T146","span":{"begin":951,"end":953},"obj":"CC"},{"id":"spaCy_T147","span":{"begin":954,"end":960},"obj":"NN"},{"id":"spaCy_T148","span":{"begin":961,"end":969},"obj":"NN"},{"id":"spaCy_T149","span":{"begin":970,"end":984},"obj":"NN"},{"id":"spaCy_T150","span":{"begin":985,"end":986},"obj":"-LRB-"},{"id":"spaCy_T151","span":{"begin":986,"end":992},"obj":"NNP"},{"id":"spaCy_T152","span":{"begin":992,"end":993},"obj":","},{"id":"spaCy_T153","span":{"begin":994,"end":1000},"obj":"NNP"},{"id":"spaCy_T154","span":{"begin":1001,"end":1008},"obj":"NNS"},{"id":"spaCy_T155","span":{"begin":1008,"end":1009},"obj":"-RRB-"},{"id":"spaCy_T156","span":{"begin":1009,"end":1010},"obj":","},{"id":"spaCy_T157","span":{"begin":1011,"end":1019},"obj":"VBD"},{"id":"spaCy_T158","span":{"begin":1020,"end":1022},"obj":"IN"},{"id":"spaCy_T159","span":{"begin":1023,"end":1029},"obj":"RB"},{"id":"spaCy_T160","span":{"begin":1030,"end":1039},"obj":"JJ"},{"id":"spaCy_T161","span":{"begin":1040,"end":1047},"obj":"NN"},{"id":"spaCy_T162","span":{"begin":1048,"end":1056},"obj":"NNS"},{"id":"spaCy_T163","span":{"begin":1057,"end":1059},"obj":"IN"},{"id":"spaCy_T164","span":{"begin":1060,"end":1063},"obj":"NNP"},{"id":"spaCy_T165","span":{"begin":1064,"end":1067},"obj":"CC"},{"id":"spaCy_T166","span":{"begin":1068,"end":1071},"obj":"NNP"},{"id":"spaCy_T167","span":{"begin":1072,"end":1082},"obj":"NNS"},{"id":"spaCy_T168","span":{"begin":1082,"end":1083},"obj":"."},{"id":"spaCy_T169","span":{"begin":1084,"end":1087},"obj":"DT"},{"id":"spaCy_T170","span":{"begin":1088,"end":1090},"obj":"IN"},{"id":"spaCy_T171","span":{"begin":1091,"end":1094},"obj":"DT"},{"id":"spaCy_T172","span":{"begin":1095,"end":1105},"obj":"JJ"},{"id":"spaCy_T173","span":{"begin":1106,"end":1115},"obj":"NNS"},{"id":"spaCy_T174","span":{"begin":1116,"end":1126},"obj":"VBG"},{"id":"spaCy_T175","span":{"begin":1127,"end":1130},"obj":"NNP"},{"id":"spaCy_T176","span":{"begin":1131,"end":1139},"obj":"NN"},{"id":"spaCy_T177","span":{"begin":1140,"end":1144},"obj":"VBD"},{"id":"spaCy_T178","span":{"begin":1145,"end":1150},"obj":"VBN"},{"id":"spaCy_T179","span":{"begin":1151,"end":1153},"obj":"TO"},{"id":"spaCy_T180","span":{"begin":1154,"end":1161},"obj":"VB"},{"id":"spaCy_T181","span":{"begin":1162,"end":1165},"obj":"NNP"},{"id":"spaCy_T182","span":{"begin":1166,"end":1168},"obj":"IN"},{"id":"spaCy_T183","span":{"begin":1169,"end":1176},"obj":"NNS"},{"id":"spaCy_T184","span":{"begin":1177,"end":1190},"obj":"JJ"},{"id":"spaCy_T185","span":{"begin":1191,"end":1193},"obj":"TO"},{"id":"spaCy_T186","span":{"begin":1194,"end":1197},"obj":"NNP"},{"id":"spaCy_T187","span":{"begin":1198,"end":1206},"obj":"NN"},{"id":"spaCy_T188","span":{"begin":1206,"end":1207},"obj":"."},{"id":"spaCy_T189","span":{"begin":1208,"end":1209},"obj":"-LRB-"},{"id":"spaCy_T190","span":{"begin":1209,"end":1210},"obj":"NN"},{"id":"spaCy_T191","span":{"begin":1210,"end":1211},"obj":"-RRB-"},{"id":"spaCy_T192","span":{"begin":1212,"end":1222},"obj":"NNP"},{"id":"spaCy_T193","span":{"begin":1223,"end":1231},"obj":"NN"},{"id":"spaCy_T194","span":{"begin":1232,"end":1240},"obj":"NN"},{"id":"spaCy_T195","span":{"begin":1241,"end":1244},"obj":"IN"},{"id":"spaCy_T196","span":{"begin":1245,"end":1254},"obj":"NNP"},{"id":"spaCy_T197","span":{"begin":1255,"end":1266},"obj":"VBD"},{"id":"spaCy_T198","span":{"begin":1267,"end":1270},"obj":"DT"},{"id":"spaCy_T199","span":{"begin":1271,"end":1278},"obj":"NN"},{"id":"spaCy_T200","span":{"begin":1279,"end":1281},"obj":"IN"},{"id":"spaCy_T201","span":{"begin":1282,"end":1292},"obj":"VBN"},{"id":"spaCy_T202","span":{"begin":1293,"end":1303},"obj":"NN"},{"id":"spaCy_T203","span":{"begin":1304,"end":1316},"obj":"NNS"},{"id":"spaCy_T204","span":{"begin":1317,"end":1319},"obj":"TO"},{"id":"spaCy_T205","span":{"begin":1320,"end":1326},"obj":"VB"},{"id":"spaCy_T206","span":{"begin":1327,"end":1332},"obj":"JJ"},{"id":"spaCy_T207","span":{"begin":1333,"end":1341},"obj":"NN"},{"id":"spaCy_T208","span":{"begin":1342,"end":1353},"obj":"NN"},{"id":"spaCy_T209","span":{"begin":1354,"end":1362},"obj":"NN"},{"id":"spaCy_T210","span":{"begin":1362,"end":1363},"obj":"."},{"id":"spaCy_T211","span":{"begin":1364,"end":1368},"obj":"DT"},{"id":"spaCy_T212","span":{"begin":1369,"end":1377},"obj":"NN"},{"id":"spaCy_T213","span":{"begin":1378,"end":1382},"obj":"RB"},{"id":"spaCy_T214","span":{"begin":1383,"end":1394},"obj":"VBD"},{"id":"spaCy_T215","span":{"begin":1395,"end":1398},"obj":"DT"},{"id":"spaCy_T216","span":{"begin":1399,"end":1402},"obj":"NNP"},{"id":"spaCy_T217","span":{"begin":1403,"end":1411},"obj":"NN"},{"id":"spaCy_T218","span":{"begin":1412,"end":1414},"obj":"IN"},{"id":"spaCy_T219","span":{"begin":1415,"end":1423},"obj":"VBN"},{"id":"spaCy_T220","span":{"begin":1424,"end":1433},"obj":"NNP"},{"id":"spaCy_T221","span":{"begin":1434,"end":1437},"obj":"CC"},{"id":"spaCy_T222","span":{"begin":1438,"end":1441},"obj":"RB"},{"id":"spaCy_T223","span":{"begin":1442,"end":1458},"obj":"JJ"},{"id":"spaCy_T224","span":{"begin":1458,"end":1459},"obj":"."},{"id":"spaCy_T225","span":{"begin":1460,"end":1461},"obj":"-LRB-"},{"id":"spaCy_T226","span":{"begin":1461,"end":1462},"obj":"NN"},{"id":"spaCy_T227","span":{"begin":1462,"end":1463},"obj":"-RRB-"},{"id":"spaCy_T228","span":{"begin":1464,"end":1467},"obj":"DT"},{"id":"spaCy_T229","span":{"begin":1468,"end":1478},"obj":"JJ"},{"id":"spaCy_T230","span":{"begin":1479,"end":1482},"obj":"NNP"},{"id":"spaCy_T231","span":{"begin":1483,"end":1491},"obj":"NN"},{"id":"spaCy_T232","span":{"begin":1492,"end":1494},"obj":"IN"},{"id":"spaCy_T233","span":{"begin":1495,"end":1504},"obj":"VBN"},{"id":"spaCy_T234","span":{"begin":1505,"end":1515},"obj":"NN"},{"id":"spaCy_T235","span":{"begin":1516,"end":1528},"obj":"NNS"},{"id":"spaCy_T236","span":{"begin":1529,"end":1532},"obj":"CC"},{"id":"spaCy_T237","span":{"begin":1533,"end":1542},"obj":"NN"},{"id":"spaCy_T238","span":{"begin":1543,"end":1547},"obj":"VBD"},{"id":"spaCy_T239","span":{"begin":1548,"end":1555},"obj":"JJ"},{"id":"spaCy_T240","span":{"begin":1555,"end":1556},"obj":"."},{"id":"spaCy_T241","span":{"begin":1557,"end":1565},"obj":"NN"},{"id":"spaCy_T242","span":{"begin":1566,"end":1572},"obj":"IN"},{"id":"spaCy_T243","span":{"begin":1573,"end":1576},"obj":"NNP"},{"id":"spaCy_T244","span":{"begin":1577,"end":1585},"obj":"NN"},{"id":"spaCy_T245","span":{"begin":1586,"end":1589},"obj":"IN"},{"id":"spaCy_T246","span":{"begin":1590,"end":1599},"obj":"NNP"},{"id":"spaCy_T247","span":{"begin":1600,"end":1603},"obj":"CC"},{"id":"spaCy_T248","span":{"begin":1604,"end":1614},"obj":"VBD"},{"id":"spaCy_T249","span":{"begin":1615,"end":1625},"obj":"NN"},{"id":"spaCy_T250","span":{"begin":1626,"end":1638},"obj":"NNS"},{"id":"spaCy_T251","span":{"begin":1639,"end":1648},"obj":"VBD"},{"id":"spaCy_T252","span":{"begin":1649,"end":1658},"obj":"JJ"},{"id":"spaCy_T253","span":{"begin":1659,"end":1665},"obj":"NNS"},{"id":"spaCy_T254","span":{"begin":1665,"end":1666},"obj":"."},{"id":"spaCy_T255","span":{"begin":1667,"end":1677},"obj":"NNP"},{"id":"spaCy_T256","span":{"begin":1678,"end":1690},"obj":"NNS"},{"id":"spaCy_T257","span":{"begin":1691,"end":1694},"obj":"CC"},{"id":"spaCy_T258","span":{"begin":1695,"end":1704},"obj":"JJ"},{"id":"spaCy_T259","span":{"begin":1705,"end":1717},"obj":"VBD"},{"id":"spaCy_T260","span":{"begin":1718,"end":1725},"obj":"JJ"},{"id":"spaCy_T261","span":{"begin":1726,"end":1729},"obj":"NNP"},{"id":"spaCy_T262","span":{"begin":1730,"end":1738},"obj":"NN"},{"id":"spaCy_T263","span":{"begin":1739,"end":1741},"obj":"IN"},{"id":"spaCy_T264","span":{"begin":1742,"end":1747},"obj":"CD"},{"id":"spaCy_T265","span":{"begin":1748,"end":1756},"obj":"NN"},{"id":"spaCy_T266","span":{"begin":1757,"end":1762},"obj":"NNS"},{"id":"spaCy_T267","span":{"begin":1762,"end":1763},"obj":":"},{"id":"spaCy_T268","span":{"begin":1764,"end":1773},"obj":"NNS"},{"id":"spaCy_T269","span":{"begin":1773,"end":1774},"obj":","},{"id":"spaCy_T270","span":{"begin":1775,"end":1777},"obj":"IN"},{"id":"spaCy_T271","span":{"begin":1778,"end":1798},"obj":"JJ"},{"id":"spaCy_T272","span":{"begin":1799,"end":1810},"obj":"NNS"},{"id":"spaCy_T273","span":{"begin":1810,"end":1811},"obj":","},{"id":"spaCy_T274","span":{"begin":1812,"end":1815},"obj":"CC"},{"id":"spaCy_T275","span":{"begin":1816,"end":1844},"obj":"JJ"},{"id":"spaCy_T276","span":{"begin":1845,"end":1856},"obj":"NNS"},{"id":"spaCy_T277","span":{"begin":1856,"end":1857},"obj":"."},{"id":"spaCy_T278","span":{"begin":1858,"end":1859},"obj":"-LRB-"},{"id":"spaCy_T279","span":{"begin":1859,"end":1860},"obj":"LS"},{"id":"spaCy_T280","span":{"begin":1860,"end":1861},"obj":"-RRB-"},{"id":"spaCy_T281","span":{"begin":1862,"end":1870},"obj":"NN"},{"id":"spaCy_T282","span":{"begin":1871,"end":1873},"obj":"IN"},{"id":"spaCy_T283","span":{"begin":1874,"end":1886},"obj":"NNS"},{"id":"spaCy_T284","span":{"begin":1887,"end":1895},"obj":"VBN"},{"id":"spaCy_T285","span":{"begin":1896,"end":1898},"obj":"IN"},{"id":"spaCy_T286","span":{"begin":1899,"end":1903},"obj":"CD"},{"id":"spaCy_T287","span":{"begin":1904,"end":1922},"obj":"JJ"},{"id":"spaCy_T288","span":{"begin":1923,"end":1928},"obj":"JJ"},{"id":"spaCy_T289","span":{"begin":1929,"end":1935},"obj":"NN"},{"id":"spaCy_T290","span":{"begin":1936,"end":1942},"obj":"NNS"},{"id":"spaCy_T291","span":{"begin":1943,"end":1955},"obj":"VBD"},{"id":"spaCy_T292","span":{"begin":1956,"end":1966},"obj":"VB"},{"id":"spaCy_T293","span":{"begin":1967,"end":1977},"obj":"NN"},{"id":"spaCy_T294","span":{"begin":1978,"end":1980},"obj":"IN"},{"id":"spaCy_T295","span":{"begin":1981,"end":1984},"obj":"NNP"},{"id":"spaCy_T296","span":{"begin":1985,"end":1988},"obj":"CC"},{"id":"spaCy_T297","span":{"begin":1989,"end":1992},"obj":"NNP"},{"id":"spaCy_T298","span":{"begin":1992,"end":1993},"obj":"."},{"id":"spaCy_T299","span":{"begin":1994,"end":1999},"obj":"DT"},{"id":"spaCy_T300","span":{"begin":2000,"end":2007},"obj":"NNS"},{"id":"spaCy_T301","span":{"begin":2008,"end":2015},"obj":"VBP"},{"id":"spaCy_T302","span":{"begin":2016,"end":2026},"obj":"JJ"},{"id":"spaCy_T303","span":{"begin":2027,"end":2035},"obj":"NN"},{"id":"spaCy_T304","span":{"begin":2036,"end":2039},"obj":"IN"},{"id":"spaCy_T305","span":{"begin":2040,"end":2047},"obj":"NN"},{"id":"spaCy_T306","span":{"begin":2048,"end":2050},"obj":"IN"},{"id":"spaCy_T307","span":{"begin":2051,"end":2054},"obj":"DT"},{"id":"spaCy_T308","span":{"begin":2055,"end":2062},"obj":"NN"},{"id":"spaCy_T309","span":{"begin":2063,"end":2067},"obj":"WDT"},{"id":"spaCy_T310","span":{"begin":2068,"end":2077},"obj":"NNP"},{"id":"spaCy_T311","span":{"begin":2078,"end":2080},"obj":"VBZ"},{"id":"spaCy_T312","span":{"begin":2081,"end":2084},"obj":"DT"},{"id":"spaCy_T313","span":{"begin":2085,"end":2090},"obj":"JJ"},{"id":"spaCy_T314","span":{"begin":2091,"end":2096},"obj":"JJ"},{"id":"spaCy_T315","span":{"begin":2097,"end":2107},"obj":"NN"},{"id":"spaCy_T316","span":{"begin":2108,"end":2115},"obj":"JJ"},{"id":"spaCy_T317","span":{"begin":2116,"end":2118},"obj":"IN"},{"id":"spaCy_T318","span":{"begin":2119,"end":2127},"obj":"VBG"},{"id":"spaCy_T319","span":{"begin":2128,"end":2147},"obj":"JJ"},{"id":"spaCy_T320","span":{"begin":2148,"end":2159},"obj":"JJ"},{"id":"spaCy_T321","span":{"begin":2160,"end":2168},"obj":"NN"},{"id":"spaCy_T322","span":{"begin":2168,"end":2169},"obj":"."}],"relations":[{"id":"spaCy_R0","pred":"nmod","subj":"spaCy_T0","obj":"spaCy_T5"},{"id":"spaCy_R1","pred":"amod","subj":"spaCy_T1","obj":"spaCy_T5"},{"id":"spaCy_R2","pred":"amod","subj":"spaCy_T2","obj":"spaCy_T3"},{"id":"spaCy_R3","pred":"compound","subj":"spaCy_T3","obj":"spaCy_T5"},{"id":"spaCy_R4","pred":"compound","subj":"spaCy_T4","obj":"spaCy_T5"},{"id":"spaCy_R5","pred":"ROOT","subj":"spaCy_T5","obj":"spaCy_T5"},{"id":"spaCy_R6","pred":"punct","subj":"spaCy_T6","obj":"spaCy_T5"},{"id":"spaCy_R7","pred":"appos","subj":"spaCy_T7","obj":"spaCy_T5"},{"id":"spaCy_R8","pred":"prep","subj":"spaCy_T8","obj":"spaCy_T7"},{"id":"spaCy_R9","pred":"det","subj":"spaCy_T9","obj":"spaCy_T10"},{"id":"spaCy_R10","pred":"pobj","subj":"spaCy_T10","obj":"spaCy_T8"},{"id":"spaCy_R11","pred":"prep","subj":"spaCy_T11","obj":"spaCy_T10"},{"id":"spaCy_R12","pred":"pobj","subj":"spaCy_T12","obj":"spaCy_T11"},{"id":"spaCy_R13","pred":"punct","subj":"spaCy_T13","obj":"spaCy_T5"},{"id":"spaCy_R14","pred":"advmod","subj":"spaCy_T14","obj":"spaCy_T22"},{"id":"spaCy_R15","pred":"punct","subj":"spaCy_T15","obj":"spaCy_T22"},{"id":"spaCy_R16","pred":"nsubjpass","subj":"spaCy_T16","obj":"spaCy_T22"},{"id":"spaCy_R17","pred":"punct","subj":"spaCy_T17","obj":"spaCy_T18"},{"id":"spaCy_R18","pred":"appos","subj":"spaCy_T18","obj":"spaCy_T16"},{"id":"spaCy_R19","pred":"punct","subj":"spaCy_T19","obj":"spaCy_T18"},{"id":"spaCy_R20","pred":"aux","subj":"spaCy_T20","obj":"spaCy_T22"},{"id":"spaCy_R21","pred":"auxpass","subj":"spaCy_T21","obj":"spaCy_T22"},{"id":"spaCy_R22","pred":"ROOT","subj":"spaCy_T22","obj":"spaCy_T22"},{"id":"spaCy_R23","pred":"aux","subj":"spaCy_T23","obj":"spaCy_T25"},{"id":"spaCy_R24","pred":"aux","subj":"spaCy_T24","obj":"spaCy_T25"},{"id":"spaCy_R25","pred":"xcomp","subj":"spaCy_T25","obj":"spaCy_T22"},{"id":"spaCy_R26","pred":"det","subj":"spaCy_T26","obj":"spaCy_T27"},{"id":"spaCy_R27","pred":"dobj","subj":"spaCy_T27","obj":"spaCy_T25"},{"id":"spaCy_R28","pred":"aux","subj":"spaCy_T28","obj":"spaCy_T29"},{"id":"spaCy_R29","pred":"acl","subj":"spaCy_T29","obj":"spaCy_T27"},{"id":"spaCy_R30","pred":"dobj","subj":"spaCy_T30","obj":"spaCy_T29"},{"id":"spaCy_R31","pred":"prep","subj":"spaCy_T31","obj":"spaCy_T29"},{"id":"spaCy_R32","pred":"amod","subj":"spaCy_T32","obj":"spaCy_T36"},{"id":"spaCy_R33","pred":"nmod","subj":"spaCy_T33","obj":"spaCy_T36"},{"id":"spaCy_R34","pred":"cc","subj":"spaCy_T34","obj":"spaCy_T33"},{"id":"spaCy_R35","pred":"conj","subj":"spaCy_T35","obj":"spaCy_T33"},{"id":"spaCy_R36","pred":"pobj","subj":"spaCy_T36","obj":"spaCy_T31"},{"id":"spaCy_R37","pred":"punct","subj":"spaCy_T37","obj":"spaCy_T22"},{"id":"spaCy_R38","pred":"det","subj":"spaCy_T38","obj":"spaCy_T39"},{"id":"spaCy_R39","pred":"nsubj","subj":"spaCy_T39","obj":"spaCy_T40"},{"id":"spaCy_R40","pred":"ROOT","subj":"spaCy_T40","obj":"spaCy_T40"},{"id":"spaCy_R41","pred":"advmod","subj":"spaCy_T41","obj":"spaCy_T40"},{"id":"spaCy_R42","pred":"auxpass","subj":"spaCy_T42","obj":"spaCy_T43"},{"id":"spaCy_R43","pred":"ccomp","subj":"spaCy_T43","obj":"spaCy_T40"},{"id":"spaCy_R44","pred":"aux","subj":"spaCy_T44","obj":"spaCy_T45"},{"id":"spaCy_R45","pred":"advcl","subj":"spaCy_T45","obj":"spaCy_T43"},{"id":"spaCy_R46","pred":"det","subj":"spaCy_T46","obj":"spaCy_T47"},{"id":"spaCy_R47","pred":"dobj","subj":"spaCy_T47","obj":"spaCy_T45"},{"id":"spaCy_R48","pred":"prep","subj":"spaCy_T48","obj":"spaCy_T47"},{"id":"spaCy_R49","pred":"det","subj":"spaCy_T49","obj":"spaCy_T50"},{"id":"spaCy_R50","pred":"pobj","subj":"spaCy_T50","obj":"spaCy_T48"},{"id":"spaCy_R51","pred":"amod","subj":"spaCy_T51","obj":"spaCy_T50"},{"id":"spaCy_R52","pred":"prep","subj":"spaCy_T52","obj":"spaCy_T51"},{"id":"spaCy_R53","pred":"pobj","subj":"spaCy_T53","obj":"spaCy_T52"},{"id":"spaCy_R54","pred":"prep","subj":"spaCy_T54","obj":"spaCy_T53"},{"id":"spaCy_R55","pred":"amod","subj":"spaCy_T55","obj":"spaCy_T56"},{"id":"spaCy_R56","pred":"pobj","subj":"spaCy_T56","obj":"spaCy_T54"},{"id":"spaCy_R57","pred":"prep","subj":"spaCy_T57","obj":"spaCy_T45"},{"id":"spaCy_R58","pred":"det","subj":"spaCy_T58","obj":"spaCy_T60"},{"id":"spaCy_R59","pred":"amod","subj":"spaCy_T59","obj":"spaCy_T60"},{"id":"spaCy_R60","pred":"pobj","subj":"spaCy_T60","obj":"spaCy_T57"},{"id":"spaCy_R61","pred":"punct","subj":"spaCy_T61","obj":"spaCy_T40"},{"id":"spaCy_R62","pred":"amod","subj":"spaCy_T62","obj":"spaCy_T63"},{"id":"spaCy_R63","pred":"nsubjpass","subj":"spaCy_T63","obj":"spaCy_T69"},{"id":"spaCy_R64","pred":"punct","subj":"spaCy_T64","obj":"spaCy_T65"},{"id":"spaCy_R65","pred":"appos","subj":"spaCy_T65","obj":"spaCy_T63"},{"id":"spaCy_R66","pred":"punct","subj":"spaCy_T66","obj":"spaCy_T65"},{"id":"spaCy_R67","pred":"nsubjpass","subj":"spaCy_T67","obj":"spaCy_T69"},{"id":"spaCy_R68","pred":"auxpass","subj":"spaCy_T68","obj":"spaCy_T69"},{"id":"spaCy_R69","pred":"ROOT","subj":"spaCy_T69","obj":"spaCy_T69"},{"id":"spaCy_R70","pred":"advcl","subj":"spaCy_T70","obj":"spaCy_T69"},{"id":"spaCy_R71","pred":"det","subj":"spaCy_T71","obj":"spaCy_T75"},{"id":"spaCy_R72","pred":"amod","subj":"spaCy_T72","obj":"spaCy_T75"},{"id":"spaCy_R73","pred":"amod","subj":"spaCy_T73","obj":"spaCy_T75"},{"id":"spaCy_R74","pred":"compound","subj":"spaCy_T74","obj":"spaCy_T75"},{"id":"spaCy_R75","pred":"dobj","subj":"spaCy_T75","obj":"spaCy_T70"},{"id":"spaCy_R76","pred":"prep","subj":"spaCy_T76","obj":"spaCy_T75"},{"id":"spaCy_R77","pred":"amod","subj":"spaCy_T77","obj":"spaCy_T78"},{"id":"spaCy_R78","pred":"pobj","subj":"spaCy_T78","obj":"spaCy_T76"},{"id":"spaCy_R79","pred":"prep","subj":"spaCy_T79","obj":"spaCy_T70"},{"id":"spaCy_R80","pred":"compound","subj":"spaCy_T80","obj":"spaCy_T81"},{"id":"spaCy_R81","pred":"pobj","subj":"spaCy_T81","obj":"spaCy_T79"},{"id":"spaCy_R82","pred":"cc","subj":"spaCy_T82","obj":"spaCy_T81"},{"id":"spaCy_R83","pred":"compound","subj":"spaCy_T83","obj":"spaCy_T84"},{"id":"spaCy_R84","pred":"conj","subj":"spaCy_T84","obj":"spaCy_T81"},{"id":"spaCy_R85","pred":"punct","subj":"spaCy_T85","obj":"spaCy_T69"},{"id":"spaCy_R86","pred":"amod","subj":"spaCy_T86","obj":"spaCy_T88"},{"id":"spaCy_R87","pred":"compound","subj":"spaCy_T87","obj":"spaCy_T88"},{"id":"spaCy_R88","pred":"nsubjpass","subj":"spaCy_T88","obj":"spaCy_T90"},{"id":"spaCy_R89","pred":"auxpass","subj":"spaCy_T89","obj":"spaCy_T90"},{"id":"spaCy_R90","pred":"ROOT","subj":"spaCy_T90","obj":"spaCy_T90"},{"id":"spaCy_R91","pred":"agent","subj":"spaCy_T91","obj":"spaCy_T90"},{"id":"spaCy_R92","pred":"pobj","subj":"spaCy_T92","obj":"spaCy_T91"},{"id":"spaCy_R93","pred":"prep","subj":"spaCy_T93","obj":"spaCy_T92"},{"id":"spaCy_R94","pred":"amod","subj":"spaCy_T94","obj":"spaCy_T97"},{"id":"spaCy_R95","pred":"compound","subj":"spaCy_T95","obj":"spaCy_T96"},{"id":"spaCy_R96","pred":"compound","subj":"spaCy_T96","obj":"spaCy_T97"},{"id":"spaCy_R97","pred":"pobj","subj":"spaCy_T97","obj":"spaCy_T93"},{"id":"spaCy_R98","pred":"prep","subj":"spaCy_T98","obj":"spaCy_T97"},{"id":"spaCy_R99","pred":"compound","subj":"spaCy_T99","obj":"spaCy_T100"},{"id":"spaCy_R100","pred":"pobj","subj":"spaCy_T100","obj":"spaCy_T98"},{"id":"spaCy_R101","pred":"prep","subj":"spaCy_T101","obj":"spaCy_T100"},{"id":"spaCy_R102","pred":"amod","subj":"spaCy_T102","obj":"spaCy_T103"},{"id":"spaCy_R103","pred":"pobj","subj":"spaCy_T103","obj":"spaCy_T101"},{"id":"spaCy_R104","pred":"punct","subj":"spaCy_T104","obj":"spaCy_T90"},{"id":"spaCy_R105","pred":"nsubjpass","subj":"spaCy_T105","obj":"spaCy_T107"},{"id":"spaCy_R106","pred":"auxpass","subj":"spaCy_T106","obj":"spaCy_T107"},{"id":"spaCy_R107","pred":"ROOT","subj":"spaCy_T107","obj":"spaCy_T107"},{"id":"spaCy_R108","pred":"prep","subj":"spaCy_T108","obj":"spaCy_T107"},{"id":"spaCy_R109","pred":"det","subj":"spaCy_T109","obj":"spaCy_T111"},{"id":"spaCy_R110","pred":"amod","subj":"spaCy_T110","obj":"spaCy_T111"},{"id":"spaCy_R111","pred":"pobj","subj":"spaCy_T111","obj":"spaCy_T108"},{"id":"spaCy_R112","pred":"punct","subj":"spaCy_T112","obj":"spaCy_T107"},{"id":"spaCy_R113","pred":"nummod","subj":"spaCy_T113","obj":"spaCy_T114"},{"id":"spaCy_R114","pred":"nsubj","subj":"spaCy_T114","obj":"spaCy_T117"},{"id":"spaCy_R115","pred":"prep","subj":"spaCy_T115","obj":"spaCy_T114"},{"id":"spaCy_R116","pred":"pobj","subj":"spaCy_T116","obj":"spaCy_T115"},{"id":"spaCy_R117","pred":"ROOT","subj":"spaCy_T117","obj":"spaCy_T117"},{"id":"spaCy_R118","pred":"prep","subj":"spaCy_T118","obj":"spaCy_T117"},{"id":"spaCy_R119","pred":"det","subj":"spaCy_T119","obj":"spaCy_T120"},{"id":"spaCy_R120","pred":"pobj","subj":"spaCy_T120","obj":"spaCy_T118"},{"id":"spaCy_R121","pred":"mark","subj":"spaCy_T121","obj":"spaCy_T125"},{"id":"spaCy_R122","pred":"nsubj","subj":"spaCy_T122","obj":"spaCy_T125"},{"id":"spaCy_R123","pred":"cc","subj":"spaCy_T123","obj":"spaCy_T122"},{"id":"spaCy_R124","pred":"conj","subj":"spaCy_T124","obj":"spaCy_T122"},{"id":"spaCy_R125","pred":"acl","subj":"spaCy_T125","obj":"spaCy_T120"},{"id":"spaCy_R126","pred":"acomp","subj":"spaCy_T126","obj":"spaCy_T125"},{"id":"spaCy_R127","pred":"prep","subj":"spaCy_T127","obj":"spaCy_T126"},{"id":"spaCy_R128","pred":"det","subj":"spaCy_T128","obj":"spaCy_T129"},{"id":"spaCy_R129","pred":"pobj","subj":"spaCy_T129","obj":"spaCy_T127"},{"id":"spaCy_R130","pred":"punct","subj":"spaCy_T130","obj":"spaCy_T120"},{"id":"spaCy_R131","pred":"punct","subj":"spaCy_T131","obj":"spaCy_T132"},{"id":"spaCy_R132","pred":"nummod","subj":"spaCy_T132","obj":"spaCy_T134"},{"id":"spaCy_R133","pred":"punct","subj":"spaCy_T133","obj":"spaCy_T132"},{"id":"spaCy_R134","pred":"appos","subj":"spaCy_T134","obj":"spaCy_T120"},{"id":"spaCy_R135","pred":"prep","subj":"spaCy_T135","obj":"spaCy_T134"},{"id":"spaCy_R136","pred":"amod","subj":"spaCy_T136","obj":"spaCy_T138"},{"id":"spaCy_R137","pred":"compound","subj":"spaCy_T137","obj":"spaCy_T138"},{"id":"spaCy_R138","pred":"pobj","subj":"spaCy_T138","obj":"spaCy_T135"},{"id":"spaCy_R139","pred":"prep","subj":"spaCy_T139","obj":"spaCy_T134"},{"id":"spaCy_R140","pred":"compound","subj":"spaCy_T140","obj":"spaCy_T141"},{"id":"spaCy_R141","pred":"pobj","subj":"spaCy_T141","obj":"spaCy_T139"},{"id":"spaCy_R142","pred":"punct","subj":"spaCy_T142","obj":"spaCy_T120"},{"id":"spaCy_R143","pred":"acl","subj":"spaCy_T143","obj":"spaCy_T120"},{"id":"spaCy_R144","pred":"agent","subj":"spaCy_T144","obj":"spaCy_T143"},{"id":"spaCy_R145","pred":"pobj","subj":"spaCy_T145","obj":"spaCy_T144"},{"id":"spaCy_R146","pred":"cc","subj":"spaCy_T146","obj":"spaCy_T145"},{"id":"spaCy_R147","pred":"conj","subj":"spaCy_T147","obj":"spaCy_T145"},{"id":"spaCy_R148","pred":"compound","subj":"spaCy_T148","obj":"spaCy_T149"},{"id":"spaCy_R149","pred":"appos","subj":"spaCy_T149","obj":"spaCy_T147"},{"id":"spaCy_R150","pred":"punct","subj":"spaCy_T150","obj":"spaCy_T151"},{"id":"spaCy_R151","pred":"appos","subj":"spaCy_T151","obj":"spaCy_T149"},{"id":"spaCy_R152","pred":"punct","subj":"spaCy_T152","obj":"spaCy_T151"},{"id":"spaCy_R153","pred":"compound","subj":"spaCy_T153","obj":"spaCy_T154"},{"id":"spaCy_R154","pred":"appos","subj":"spaCy_T154","obj":"spaCy_T151"},{"id":"spaCy_R155","pred":"punct","subj":"spaCy_T155","obj":"spaCy_T151"},{"id":"spaCy_R156","pred":"punct","subj":"spaCy_T156","obj":"spaCy_T157"},{"id":"spaCy_R157","pred":"acl","subj":"spaCy_T157","obj":"spaCy_T120"},{"id":"spaCy_R158","pred":"prep","subj":"spaCy_T158","obj":"spaCy_T157"},{"id":"spaCy_R159","pred":"advmod","subj":"spaCy_T159","obj":"spaCy_T160"},{"id":"spaCy_R160","pred":"amod","subj":"spaCy_T160","obj":"spaCy_T162"},{"id":"spaCy_R161","pred":"compound","subj":"spaCy_T161","obj":"spaCy_T162"},{"id":"spaCy_R162","pred":"pobj","subj":"spaCy_T162","obj":"spaCy_T158"},{"id":"spaCy_R163","pred":"prep","subj":"spaCy_T163","obj":"spaCy_T162"},{"id":"spaCy_R164","pred":"nmod","subj":"spaCy_T164","obj":"spaCy_T167"},{"id":"spaCy_R165","pred":"cc","subj":"spaCy_T165","obj":"spaCy_T164"},{"id":"spaCy_R166","pred":"conj","subj":"spaCy_T166","obj":"spaCy_T164"},{"id":"spaCy_R167","pred":"pobj","subj":"spaCy_T167","obj":"spaCy_T163"},{"id":"spaCy_R168","pred":"punct","subj":"spaCy_T168","obj":"spaCy_T117"},{"id":"spaCy_R169","pred":"nsubjpass","subj":"spaCy_T169","obj":"spaCy_T178"},{"id":"spaCy_R170","pred":"prep","subj":"spaCy_T170","obj":"spaCy_T169"},{"id":"spaCy_R171","pred":"det","subj":"spaCy_T171","obj":"spaCy_T173"},{"id":"spaCy_R172","pred":"amod","subj":"spaCy_T172","obj":"spaCy_T173"},{"id":"spaCy_R173","pred":"pobj","subj":"spaCy_T173","obj":"spaCy_T170"},{"id":"spaCy_R174","pred":"acl","subj":"spaCy_T174","obj":"spaCy_T173"},{"id":"spaCy_R175","pred":"compound","subj":"spaCy_T175","obj":"spaCy_T176"},{"id":"spaCy_R176","pred":"dobj","subj":"spaCy_T176","obj":"spaCy_T174"},{"id":"spaCy_R177","pred":"auxpass","subj":"spaCy_T177","obj":"spaCy_T178"},{"id":"spaCy_R178","pred":"ROOT","subj":"spaCy_T178","obj":"spaCy_T178"},{"id":"spaCy_R179","pred":"aux","subj":"spaCy_T179","obj":"spaCy_T180"},{"id":"spaCy_R180","pred":"xcomp","subj":"spaCy_T180","obj":"spaCy_T178"},{"id":"spaCy_R181","pred":"dobj","subj":"spaCy_T181","obj":"spaCy_T180"},{"id":"spaCy_R182","pred":"prep","subj":"spaCy_T182","obj":"spaCy_T178"},{"id":"spaCy_R183","pred":"pobj","subj":"spaCy_T183","obj":"spaCy_T182"},{"id":"spaCy_R184","pred":"amod","subj":"spaCy_T184","obj":"spaCy_T183"},{"id":"spaCy_R185","pred":"prep","subj":"spaCy_T185","obj":"spaCy_T184"},{"id":"spaCy_R186","pred":"compound","subj":"spaCy_T186","obj":"spaCy_T187"},{"id":"spaCy_R187","pred":"pobj","subj":"spaCy_T187","obj":"spaCy_T185"},{"id":"spaCy_R188","pred":"punct","subj":"spaCy_T188","obj":"spaCy_T178"},{"id":"spaCy_R189","pred":"punct","subj":"spaCy_T189","obj":"spaCy_T190"},{"id":"spaCy_R190","pred":"ROOT","subj":"spaCy_T190","obj":"spaCy_T190"},{"id":"spaCy_R191","pred":"punct","subj":"spaCy_T191","obj":"spaCy_T190"},{"id":"spaCy_R192","pred":"compound","subj":"spaCy_T192","obj":"spaCy_T194"},{"id":"spaCy_R193","pred":"compound","subj":"spaCy_T193","obj":"spaCy_T194"},{"id":"spaCy_R194","pred":"nsubj","subj":"spaCy_T194","obj":"spaCy_T197"},{"id":"spaCy_R195","pred":"prep","subj":"spaCy_T195","obj":"spaCy_T194"},{"id":"spaCy_R196","pred":"pobj","subj":"spaCy_T196","obj":"spaCy_T195"},{"id":"spaCy_R197","pred":"ROOT","subj":"spaCy_T197","obj":"spaCy_T197"},{"id":"spaCy_R198","pred":"det","subj":"spaCy_T198","obj":"spaCy_T199"},{"id":"spaCy_R199","pred":"dobj","subj":"spaCy_T199","obj":"spaCy_T197"},{"id":"spaCy_R200","pred":"prep","subj":"spaCy_T200","obj":"spaCy_T199"},{"id":"spaCy_R201","pred":"amod","subj":"spaCy_T201","obj":"spaCy_T203"},{"id":"spaCy_R202","pred":"compound","subj":"spaCy_T202","obj":"spaCy_T203"},{"id":"spaCy_R203","pred":"pobj","subj":"spaCy_T203","obj":"spaCy_T200"},{"id":"spaCy_R204","pred":"aux","subj":"spaCy_T204","obj":"spaCy_T205"},{"id":"spaCy_R205","pred":"acl","subj":"spaCy_T205","obj":"spaCy_T199"},{"id":"spaCy_R206","pred":"amod","subj":"spaCy_T206","obj":"spaCy_T207"},{"id":"spaCy_R207","pred":"compound","subj":"spaCy_T207","obj":"spaCy_T209"},{"id":"spaCy_R208","pred":"compound","subj":"spaCy_T208","obj":"spaCy_T209"},{"id":"spaCy_R209","pred":"dobj","subj":"spaCy_T209","obj":"spaCy_T205"},{"id":"spaCy_R210","pred":"punct","subj":"spaCy_T210","obj":"spaCy_T197"},{"id":"spaCy_R211","pred":"det","subj":"spaCy_T211","obj":"spaCy_T212"},{"id":"spaCy_R212","pred":"nsubj","subj":"spaCy_T212","obj":"spaCy_T214"},{"id":"spaCy_R213","pred":"advmod","subj":"spaCy_T213","obj":"spaCy_T214"},{"id":"spaCy_R214","pred":"ROOT","subj":"spaCy_T214","obj":"spaCy_T214"},{"id":"spaCy_R215","pred":"det","subj":"spaCy_T215","obj":"spaCy_T217"},{"id":"spaCy_R216","pred":"compound","subj":"spaCy_T216","obj":"spaCy_T217"},{"id":"spaCy_R217","pred":"dobj","subj":"spaCy_T217","obj":"spaCy_T214"},{"id":"spaCy_R218","pred":"prep","subj":"spaCy_T218","obj":"spaCy_T217"},{"id":"spaCy_R219","pred":"amod","subj":"spaCy_T219","obj":"spaCy_T220"},{"id":"spaCy_R220","pred":"pobj","subj":"spaCy_T220","obj":"spaCy_T218"},{"id":"spaCy_R221","pred":"cc","subj":"spaCy_T221","obj":"spaCy_T217"},{"id":"spaCy_R222","pred":"neg","subj":"spaCy_T222","obj":"spaCy_T223"},{"id":"spaCy_R223","pred":"conj","subj":"spaCy_T223","obj":"spaCy_T214"},{"id":"spaCy_R224","pred":"punct","subj":"spaCy_T224","obj":"spaCy_T214"},{"id":"spaCy_R225","pred":"punct","subj":"spaCy_T225","obj":"spaCy_T226"},{"id":"spaCy_R226","pred":"ROOT","subj":"spaCy_T226","obj":"spaCy_T226"},{"id":"spaCy_R227","pred":"punct","subj":"spaCy_T227","obj":"spaCy_T226"},{"id":"spaCy_R228","pred":"det","subj":"spaCy_T228","obj":"spaCy_T231"},{"id":"spaCy_R229","pred":"amod","subj":"spaCy_T229","obj":"spaCy_T231"},{"id":"spaCy_R230","pred":"compound","subj":"spaCy_T230","obj":"spaCy_T231"},{"id":"spaCy_R231","pred":"nsubj","subj":"spaCy_T231","obj":"spaCy_T238"},{"id":"spaCy_R232","pred":"prep","subj":"spaCy_T232","obj":"spaCy_T231"},{"id":"spaCy_R233","pred":"amod","subj":"spaCy_T233","obj":"spaCy_T235"},{"id":"spaCy_R234","pred":"compound","subj":"spaCy_T234","obj":"spaCy_T235"},{"id":"spaCy_R235","pred":"pobj","subj":"spaCy_T235","obj":"spaCy_T232"},{"id":"spaCy_R236","pred":"cc","subj":"spaCy_T236","obj":"spaCy_T235"},{"id":"spaCy_R237","pred":"conj","subj":"spaCy_T237","obj":"spaCy_T235"},{"id":"spaCy_R238","pred":"ROOT","subj":"spaCy_T238","obj":"spaCy_T238"},{"id":"spaCy_R239","pred":"acomp","subj":"spaCy_T239","obj":"spaCy_T238"},{"id":"spaCy_R240","pred":"punct","subj":"spaCy_T240","obj":"spaCy_T238"},{"id":"spaCy_R241","pred":"nsubj","subj":"spaCy_T241","obj":"spaCy_T248"},{"id":"spaCy_R242","pred":"prep","subj":"spaCy_T242","obj":"spaCy_T241"},{"id":"spaCy_R243","pred":"compound","subj":"spaCy_T243","obj":"spaCy_T244"},{"id":"spaCy_R244","pred":"pobj","subj":"spaCy_T244","obj":"spaCy_T242"},{"id":"spaCy_R245","pred":"prep","subj":"spaCy_T245","obj":"spaCy_T244"},{"id":"spaCy_R246","pred":"pobj","subj":"spaCy_T246","obj":"spaCy_T245"},{"id":"spaCy_R247","pred":"cc","subj":"spaCy_T247","obj":"spaCy_T241"},{"id":"spaCy_R248","pred":"ROOT","subj":"spaCy_T248","obj":"spaCy_T248"},{"id":"spaCy_R249","pred":"compound","subj":"spaCy_T249","obj":"spaCy_T250"},{"id":"spaCy_R250","pred":"nsubj","subj":"spaCy_T250","obj":"spaCy_T251"},{"id":"spaCy_R251","pred":"ccomp","subj":"spaCy_T251","obj":"spaCy_T248"},{"id":"spaCy_R252","pred":"amod","subj":"spaCy_T252","obj":"spaCy_T253"},{"id":"spaCy_R253","pred":"dobj","subj":"spaCy_T253","obj":"spaCy_T251"},{"id":"spaCy_R254","pred":"punct","subj":"spaCy_T254","obj":"spaCy_T248"},{"id":"spaCy_R255","pred":"compound","subj":"spaCy_T255","obj":"spaCy_T256"},{"id":"spaCy_R256","pred":"nsubj","subj":"spaCy_T256","obj":"spaCy_T259"},{"id":"spaCy_R257","pred":"cc","subj":"spaCy_T257","obj":"spaCy_T256"},{"id":"spaCy_R258","pred":"conj","subj":"spaCy_T258","obj":"spaCy_T256"},{"id":"spaCy_R259","pred":"ROOT","subj":"spaCy_T259","obj":"spaCy_T259"},{"id":"spaCy_R260","pred":"amod","subj":"spaCy_T260","obj":"spaCy_T262"},{"id":"spaCy_R261","pred":"compound","subj":"spaCy_T261","obj":"spaCy_T262"},{"id":"spaCy_R262","pred":"dobj","subj":"spaCy_T262","obj":"spaCy_T259"},{"id":"spaCy_R263","pred":"prep","subj":"spaCy_T263","obj":"spaCy_T259"},{"id":"spaCy_R264","pred":"nummod","subj":"spaCy_T264","obj":"spaCy_T266"},{"id":"spaCy_R265","pred":"compound","subj":"spaCy_T265","obj":"spaCy_T266"},{"id":"spaCy_R266","pred":"pobj","subj":"spaCy_T266","obj":"spaCy_T263"},{"id":"spaCy_R267","pred":"punct","subj":"spaCy_T267","obj":"spaCy_T266"},{"id":"spaCy_R268","pred":"appos","subj":"spaCy_T268","obj":"spaCy_T266"},{"id":"spaCy_R269","pred":"punct","subj":"spaCy_T269","obj":"spaCy_T268"},{"id":"spaCy_R270","pred":"prep","subj":"spaCy_T270","obj":"spaCy_T268"},{"id":"spaCy_R271","pred":"compound","subj":"spaCy_T271","obj":"spaCy_T272"},{"id":"spaCy_R272","pred":"pobj","subj":"spaCy_T272","obj":"spaCy_T270"},{"id":"spaCy_R273","pred":"punct","subj":"spaCy_T273","obj":"spaCy_T268"},{"id":"spaCy_R274","pred":"cc","subj":"spaCy_T274","obj":"spaCy_T268"},{"id":"spaCy_R275","pred":"amod","subj":"spaCy_T275","obj":"spaCy_T276"},{"id":"spaCy_R276","pred":"conj","subj":"spaCy_T276","obj":"spaCy_T268"},{"id":"spaCy_R277","pred":"punct","subj":"spaCy_T277","obj":"spaCy_T259"},{"id":"spaCy_R278","pred":"punct","subj":"spaCy_T278","obj":"spaCy_T279"},{"id":"spaCy_R279","pred":"meta","subj":"spaCy_T279","obj":"spaCy_T281"},{"id":"spaCy_R280","pred":"punct","subj":"spaCy_T280","obj":"spaCy_T279"},{"id":"spaCy_R281","pred":"nsubj","subj":"spaCy_T281","obj":"spaCy_T291"},{"id":"spaCy_R282","pred":"prep","subj":"spaCy_T282","obj":"spaCy_T281"},{"id":"spaCy_R283","pred":"pobj","subj":"spaCy_T283","obj":"spaCy_T282"},{"id":"spaCy_R284","pred":"acl","subj":"spaCy_T284","obj":"spaCy_T283"},{"id":"spaCy_R285","pred":"agent","subj":"spaCy_T285","obj":"spaCy_T284"},{"id":"spaCy_R286","pred":"nummod","subj":"spaCy_T286","obj":"spaCy_T290"},{"id":"spaCy_R287","pred":"amod","subj":"spaCy_T287","obj":"spaCy_T290"},{"id":"spaCy_R288","pred":"amod","subj":"spaCy_T288","obj":"spaCy_T289"},{"id":"spaCy_R289","pred":"compound","subj":"spaCy_T289","obj":"spaCy_T290"},{"id":"spaCy_R290","pred":"pobj","subj":"spaCy_T290","obj":"spaCy_T285"},{"id":"spaCy_R291","pred":"ROOT","subj":"spaCy_T291","obj":"spaCy_T291"},{"id":"spaCy_R292","pred":"xcomp","subj":"spaCy_T292","obj":"spaCy_T291"},{"id":"spaCy_R293","pred":"dobj","subj":"spaCy_T293","obj":"spaCy_T292"},{"id":"spaCy_R294","pred":"prep","subj":"spaCy_T294","obj":"spaCy_T293"},{"id":"spaCy_R295","pred":"pobj","subj":"spaCy_T295","obj":"spaCy_T294"},{"id":"spaCy_R296","pred":"cc","subj":"spaCy_T296","obj":"spaCy_T295"},{"id":"spaCy_R297","pred":"conj","subj":"spaCy_T297","obj":"spaCy_T295"},{"id":"spaCy_R298","pred":"punct","subj":"spaCy_T298","obj":"spaCy_T291"},{"id":"spaCy_R299","pred":"det","subj":"spaCy_T299","obj":"spaCy_T300"},{"id":"spaCy_R300","pred":"nsubj","subj":"spaCy_T300","obj":"spaCy_T301"},{"id":"spaCy_R301","pred":"ROOT","subj":"spaCy_T301","obj":"spaCy_T301"},{"id":"spaCy_R302","pred":"amod","subj":"spaCy_T302","obj":"spaCy_T303"},{"id":"spaCy_R303","pred":"dobj","subj":"spaCy_T303","obj":"spaCy_T301"},{"id":"spaCy_R304","pred":"prep","subj":"spaCy_T304","obj":"spaCy_T303"},{"id":"spaCy_R305","pred":"pobj","subj":"spaCy_T305","obj":"spaCy_T304"},{"id":"spaCy_R306","pred":"prep","subj":"spaCy_T306","obj":"spaCy_T305"},{"id":"spaCy_R307","pred":"det","subj":"spaCy_T307","obj":"spaCy_T308"},{"id":"spaCy_R308","pred":"pobj","subj":"spaCy_T308","obj":"spaCy_T306"},{"id":"spaCy_R309","pred":"mark","subj":"spaCy_T309","obj":"spaCy_T311"},{"id":"spaCy_R310","pred":"nsubj","subj":"spaCy_T310","obj":"spaCy_T311"},{"id":"spaCy_R311","pred":"acl","subj":"spaCy_T311","obj":"spaCy_T308"},{"id":"spaCy_R312","pred":"det","subj":"spaCy_T312","obj":"spaCy_T315"},{"id":"spaCy_R313","pred":"amod","subj":"spaCy_T313","obj":"spaCy_T315"},{"id":"spaCy_R314","pred":"amod","subj":"spaCy_T314","obj":"spaCy_T315"},{"id":"spaCy_R315","pred":"attr","subj":"spaCy_T315","obj":"spaCy_T311"},{"id":"spaCy_R316","pred":"amod","subj":"spaCy_T316","obj":"spaCy_T315"},{"id":"spaCy_R317","pred":"prep","subj":"spaCy_T317","obj":"spaCy_T316"},{"id":"spaCy_R318","pred":"pcomp","subj":"spaCy_T318","obj":"spaCy_T317"},{"id":"spaCy_R319","pred":"amod","subj":"spaCy_T319","obj":"spaCy_T321"},{"id":"spaCy_R320","pred":"amod","subj":"spaCy_T320","obj":"spaCy_T321"},{"id":"spaCy_R321","pred":"dobj","subj":"spaCy_T321","obj":"spaCy_T318"},{"id":"spaCy_R322","pred":"punct","subj":"spaCy_T322","obj":"spaCy_T301"}],"text":"Lymphocyte supernatant-induced human monocyte tumoricidal activity: dependence on the presence of gamma-interferon.\nRecently, gamma-interferon (IFN-gamma) has been shown to be have the capacity to activate macrophages in several murine and human systems. The studies reported here were undertaken to determine the identity of the lymphokine responsible for activation of human monocytes to a tumoricidal state. Macrophage-activating factor (MAF) activity was assessed using a 24-h 51Cr release assay with human monocytes as effector cells and K-562 targets. Stimulated lymphocyte supernatants were produced by stimulation of peripheral blood mononuclear cells with concanavalin A in serum-free media. Interferon was detected in an antiviral assay. Four lines of evidence lead to the conclusion that MAF and IFN-gamma are identical in this system: (a) fractionation of stimulated lymphocyte supernatants by adsorption chromatography, followed by anion or cation exchange chromatography (Mono-S, Mono-Q columns), resulted in nearly identical elution profiles of MAF and IFN activities. All of the individual fractions containing MAF activity were found to contain IFN in amounts corresponding to MAF activity. (b) Monoclonal antibody specific for IFN-gamma neutralized the ability of stimulated lymphocyte supernatants to induce human monocyte tumoricidal activity. This antibody also neutralized the MAF activity of purified IFN-gamma but not alpha-interferon. (c) The biological MAF activity of activated lymphocyte supernatants and IFN-gamma were similar. Dilution versus MAF activity for IFN-gamma and stimulated lymphocyte supernatants exhibited identical slopes. Lymphocyte supernatants and IFN-gamma demonstrated similar MAF activity on three effector cells: monocytes, in vitro-differentiated macrophages, and dexamethasone-differentiated macrophages. (d) Analysis of supernatants produced by five antigen-stimulated human T-cell clones demonstrated coordinate production of MAF and IFN. These results provide compelling evidence for support of the concept that IFN-gamma is the major human lymphokine capable of inducing monocyte-macrophage tumoricidal activity."}

{"project":"oger-json-test","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"CL:0000542"},{"id":"T2","span":{"begin":31,"end":36},"obj":"PR:Q9Y653"},{"id":"T3","span":{"begin":31,"end":36},"obj":"9606"},{"id":"T4","span":{"begin":31,"end":36},"obj":"D006801"},{"id":"T5","span":{"begin":37,"end":45},"obj":"CL:0000576"},{"id":"T6","span":{"begin":37,"end":45},"obj":"CL:0001054"},{"id":"T7","span":{"begin":98,"end":103},"obj":"CHEBI:30212"},{"id":"T8","span":{"begin":98,"end":103},"obj":"P12799"},{"id":"T9","span":{"begin":98,"end":114},"obj":"D007371"},{"id":"T10","span":{"begin":104,"end":114},"obj":"P51527"},{"id":"T11","span":{"begin":104,"end":114},"obj":"D007372"},{"id":"T12","span":{"begin":104,"end":114},"obj":"P51526"},{"id":"T13","span":{"begin":104,"end":114},"obj":"CHEBI:52999"},{"id":"T14","span":{"begin":126,"end":131},"obj":"CHEBI:30212"},{"id":"T15","span":{"begin":126,"end":131},"obj":"P12799"},{"id":"T16","span":{"begin":126,"end":142},"obj":"D007371"},{"id":"T17","span":{"begin":132,"end":142},"obj":"P51527"},{"id":"T18","span":{"begin":132,"end":142},"obj":"D007372"},{"id":"T19","span":{"begin":132,"end":142},"obj":"P51526"},{"id":"T20","span":{"begin":132,"end":142},"obj":"CHEBI:52999"},{"id":"T21","span":{"begin":144,"end":153},"obj":"Q7TSP4"},{"id":"T22","span":{"begin":144,"end":153},"obj":"P28341"},{"id":"T23","span":{"begin":144,"end":153},"obj":"P46402"},{"id":"T24","span":{"begin":144,"end":153},"obj":"O57603"},{"id":"T25","span":{"begin":144,"end":153},"obj":"P07353"},{"id":"T26","span":{"begin":144,"end":153},"obj":"A4PIZ9"},{"id":"T27","span":{"begin":144,"end":153},"obj":"Q25BC0"},{"id":"T28","span":{"begin":144,"end":153},"obj":"PR:000000017"},{"id":"T29","span":{"begin":144,"end":153},"obj":"P49708"},{"id":"T30","span":{"begin":144,"end":153},"obj":"Q865W6"},{"id":"T31","span":{"begin":144,"end":153},"obj":"O73915"},{"id":"T32","span":{"begin":144,"end":153},"obj":"Q62574"},{"id":"T33","span":{"begin":144,"end":153},"obj":"P28333"},{"id":"T34","span":{"begin":144,"end":153},"obj":"Q9QXX2"},{"id":"T35","span":{"begin":144,"end":153},"obj":"P01580"},{"id":"T36","span":{"begin":144,"end":153},"obj":"Q8MKF5"},{"id":"T37","span":{"begin":144,"end":153},"obj":"P01579"},{"id":"T38","span":{"begin":144,"end":153},"obj":"Q2PE75"},{"id":"T39","span":{"begin":144,"end":153},"obj":"Q4ZH68"},{"id":"T40","span":{"begin":144,"end":153},"obj":"P30123"},{"id":"T41","span":{"begin":144,"end":153},"obj":"P42162"},{"id":"T42","span":{"begin":144,"end":153},"obj":"Q9TTB0"},{"id":"T43","span":{"begin":144,"end":153},"obj":"O57571"},{"id":"T44","span":{"begin":144,"end":153},"obj":"P79154"},{"id":"T45","span":{"begin":144,"end":153},"obj":"O77763"},{"id":"T46","span":{"begin":144,"end":153},"obj":"Q866Y6"},{"id":"T47","span":{"begin":144,"end":153},"obj":"O57608"},{"id":"T48","span":{"begin":144,"end":153},"obj":"Q5CCK0"},{"id":"T49","span":{"begin":144,"end":153},"obj":"P63310"},{"id":"T50","span":{"begin":144,"end":153},"obj":"Q865Y4"},{"id":"T51","span":{"begin":144,"end":153},"obj":"P17773"},{"id":"T52","span":{"begin":144,"end":153},"obj":"Q5I6S9"},{"id":"T53","span":{"begin":144,"end":153},"obj":"Q8SPW9"},{"id":"T54","span":{"begin":144,"end":153},"obj":"Q9TV67"},{"id":"T55","span":{"begin":144,"end":153},"obj":"P42161"},{"id":"T56","span":{"begin":144,"end":153},"obj":"P17803"},{"id":"T57","span":{"begin":144,"end":153},"obj":"Q9YGB9"},{"id":"T58","span":{"begin":144,"end":153},"obj":"P01581"},{"id":"T59","span":{"begin":144,"end":153},"obj":"Q1WM28"},{"id":"T60","span":{"begin":144,"end":153},"obj":"Q647G2"},{"id":"T61","span":{"begin":144,"end":153},"obj":"P42160"},{"id":"T62","span":{"begin":144,"end":153},"obj":"O35735"},{"id":"T63","span":{"begin":144,"end":153},"obj":"Q865X1"},{"id":"T64","span":{"begin":144,"end":153},"obj":"P63309"},{"id":"T65","span":{"begin":144,"end":153},"obj":"P63311"},{"id":"T66","span":{"begin":144,"end":153},"obj":"O35497"},{"id":"T67","span":{"begin":148,"end":153},"obj":"CHEBI:30212"},{"id":"T68","span":{"begin":148,"end":153},"obj":"P12799"},{"id":"T69","span":{"begin":240,"end":245},"obj":"PR:Q9Y653"},{"id":"T70","span":{"begin":240,"end":245},"obj":"9606"},{"id":"T71","span":{"begin":240,"end":245},"obj":"D006801"},{"id":"T72","span":{"begin":371,"end":376},"obj":"PR:Q9Y653"},{"id":"T73","span":{"begin":371,"end":376},"obj":"9606"},{"id":"T74","span":{"begin":371,"end":376},"obj":"D006801"},{"id":"T75","span":{"begin":387,"end":391},"obj":"A7MBU6"},{"id":"T76","span":{"begin":411,"end":421},"obj":"CL:0000235"},{"id":"T77","span":{"begin":441,"end":444},"obj":"PR:Q719N3"},{"id":"T78","span":{"begin":441,"end":444},"obj":"PR:000010045"},{"id":"T79","span":{"begin":441,"end":444},"obj":"CVCL_R844"},{"id":"T80","span":{"begin":441,"end":444},"obj":"Q719N3"},{"id":"T81","span":{"begin":474,"end":478},"obj":"CVCL_V064"},{"id":"T82","span":{"begin":476,"end":480},"obj":"CVCL_8262"},{"id":"T83","span":{"begin":481,"end":485},"obj":"CHEBI:50076"},{"id":"T84","span":{"begin":505,"end":510},"obj":"PR:Q9Y653"},{"id":"T85","span":{"begin":505,"end":510},"obj":"9606"},{"id":"T86","span":{"begin":505,"end":510},"obj":"D006801"},{"id":"T87","span":{"begin":524,"end":532},"obj":"CHEBI:35224"},{"id":"T88","span":{"begin":543,"end":548},"obj":"CVCL_0004"},{"id":"T89","span":{"begin":569,"end":579},"obj":"CL:0000542"},{"id":"T90","span":{"begin":665,"end":679},"obj":"P81460"},{"id":"T91","span":{"begin":665,"end":679},"obj":"P81461"},{"id":"T92","span":{"begin":665,"end":679},"obj":"P14894"},{"id":"T93","span":{"begin":665,"end":679},"obj":"P02866"},{"id":"T94","span":{"begin":665,"end":679},"obj":"D003208"},{"id":"T95","span":{"begin":683,"end":699},"obj":"D016895"},{"id":"T96","span":{"begin":689,"end":693},"obj":"SO:0001516"},{"id":"T97","span":{"begin":701,"end":711},"obj":"P51527"},{"id":"T98","span":{"begin":701,"end":711},"obj":"D007372"},{"id":"T99","span":{"begin":701,"end":711},"obj":"P51526"},{"id":"T100","span":{"begin":701,"end":711},"obj":"CHEBI:52999"},{"id":"T101","span":{"begin":731,"end":740},"obj":"CHEBI:22587"},{"id":"T102","span":{"begin":771,"end":775},"obj":"CHEBI:27889"},{"id":"T103","span":{"begin":771,"end":775},"obj":"CHEBI:25016"},{"id":"T104","span":{"begin":799,"end":802},"obj":"PR:Q719N3"},{"id":"T105","span":{"begin":799,"end":802},"obj":"PR:000010045"},{"id":"T106","span":{"begin":799,"end":802},"obj":"CVCL_R844"},{"id":"T107","span":{"begin":799,"end":802},"obj":"Q719N3"},{"id":"T108","span":{"begin":807,"end":816},"obj":"Q7TSP4"},{"id":"T109","span":{"begin":807,"end":816},"obj":"P28341"},{"id":"T110","span":{"begin":807,"end":816},"obj":"P46402"},{"id":"T111","span":{"begin":807,"end":816},"obj":"O57603"},{"id":"T112","span":{"begin":807,"end":816},"obj":"P07353"},{"id":"T113","span":{"begin":807,"end":816},"obj":"A4PIZ9"},{"id":"T114","span":{"begin":807,"end":816},"obj":"Q25BC0"},{"id":"T115","span":{"begin":807,"end":816},"obj":"PR:000000017"},{"id":"T116","span":{"begin":807,"end":816},"obj":"P49708"},{"id":"T117","span":{"begin":807,"end":816},"obj":"Q865W6"},{"id":"T118","span":{"begin":807,"end":816},"obj":"O73915"},{"id":"T119","span":{"begin":807,"end":816},"obj":"Q62574"},{"id":"T120","span":{"begin":807,"end":816},"obj":"P28333"},{"id":"T121","span":{"begin":807,"end":816},"obj":"Q9QXX2"},{"id":"T122","span":{"begin":807,"end":816},"obj":"P01580"},{"id":"T123","span":{"begin":807,"end":816},"obj":"Q8MKF5"},{"id":"T124","span":{"begin":807,"end":816},"obj":"P01579"},{"id":"T125","span":{"begin":807,"end":816},"obj":"Q2PE75"},{"id":"T126","span":{"begin":807,"end":816},"obj":"Q4ZH68"},{"id":"T127","span":{"begin":807,"end":816},"obj":"P30123"},{"id":"T128","span":{"begin":807,"end":816},"obj":"P42162"},{"id":"T129","span":{"begin":807,"end":816},"obj":"Q9TTB0"},{"id":"T130","span":{"begin":807,"end":816},"obj":"O57571"},{"id":"T131","span":{"begin":807,"end":816},"obj":"P79154"},{"id":"T132","span":{"begin":807,"end":816},"obj":"O77763"},{"id":"T133","span":{"begin":807,"end":816},"obj":"Q866Y6"},{"id":"T134","span":{"begin":807,"end":816},"obj":"O57608"},{"id":"T135","span":{"begin":807,"end":816},"obj":"Q5CCK0"},{"id":"T136","span":{"begin":807,"end":816},"obj":"P63310"},{"id":"T137","span":{"begin":807,"end":816},"obj":"Q865Y4"},{"id":"T138","span":{"begin":807,"end":816},"obj":"P17773"},{"id":"T139","span":{"begin":807,"end":816},"obj":"Q5I6S9"},{"id":"T140","span":{"begin":807,"end":816},"obj":"Q8SPW9"},{"id":"T141","span":{"begin":807,"end":816},"obj":"Q9TV67"},{"id":"T142","span":{"begin":807,"end":816},"obj":"P42161"},{"id":"T143","span":{"begin":807,"end":816},"obj":"P17803"},{"id":"T144","span":{"begin":807,"end":816},"obj":"Q9YGB9"},{"id":"T145","span":{"begin":807,"end":816},"obj":"P01581"},{"id":"T146","span":{"begin":807,"end":816},"obj":"Q1WM28"},{"id":"T147","span":{"begin":807,"end":816},"obj":"Q647G2"},{"id":"T148","span":{"begin":807,"end":816},"obj":"P42160"},{"id":"T149","span":{"begin":807,"end":816},"obj":"O35735"},{"id":"T150","span":{"begin":807,"end":816},"obj":"Q865X1"},{"id":"T151","span":{"begin":807,"end":816},"obj":"P63309"},{"id":"T152","span":{"begin":807,"end":816},"obj":"P63311"},{"id":"T153","span":{"begin":807,"end":816},"obj":"O35497"},{"id":"T154","span":{"begin":811,"end":816},"obj":"CHEBI:30212"},{"id":"T155","span":{"begin":811,"end":816},"obj":"P12799"},{"id":"T156","span":{"begin":879,"end":889},"obj":"CL:0000542"},{"id":"T157","span":{"begin":945,"end":950},"obj":"CHEBI:22563"},{"id":"T158","span":{"begin":954,"end":960},"obj":"CHEBI:36916"},{"id":"T159","span":{"begin":986,"end":992},"obj":"C106553"},{"id":"T160","span":{"begin":994,"end":1000},"obj":"C042855"},{"id":"T161","span":{"begin":1060,"end":1063},"obj":"PR:Q719N3"},{"id":"T162","span":{"begin":1060,"end":1063},"obj":"PR:000010045"},{"id":"T163","span":{"begin":1060,"end":1063},"obj":"CVCL_R844"},{"id":"T164","span":{"begin":1060,"end":1063},"obj":"Q719N3"},{"id":"T165","span":{"begin":1084,"end":1087},"obj":"CHEBI:37690"},{"id":"T166","span":{"begin":1127,"end":1130},"obj":"PR:Q719N3"},{"id":"T167","span":{"begin":1127,"end":1130},"obj":"PR:000010045"},{"id":"T168","span":{"begin":1127,"end":1130},"obj":"CVCL_R844"},{"id":"T169","span":{"begin":1127,"end":1130},"obj":"Q719N3"},{"id":"T170","span":{"begin":1194,"end":1197},"obj":"PR:Q719N3"},{"id":"T171","span":{"begin":1194,"end":1197},"obj":"PR:000010045"},{"id":"T172","span":{"begin":1194,"end":1197},"obj":"CVCL_R844"},{"id":"T173","span":{"begin":1194,"end":1197},"obj":"Q719N3"},{"id":"T174","span":{"begin":1223,"end":1231},"obj":"GO:0019815"},{"id":"T175","span":{"begin":1223,"end":1231},"obj":"GO:0042571"},{"id":"T176","span":{"begin":1223,"end":1231},"obj":"GO:0003823"},{"id":"T177","span":{"begin":1245,"end":1254},"obj":"Q7TSP4"},{"id":"T178","span":{"begin":1245,"end":1254},"obj":"P28341"},{"id":"T179","span":{"begin":1245,"end":1254},"obj":"P46402"},{"id":"T180","span":{"begin":1245,"end":1254},"obj":"O57603"},{"id":"T181","span":{"begin":1245,"end":1254},"obj":"P07353"},{"id":"T182","span":{"begin":1245,"end":1254},"obj":"A4PIZ9"},{"id":"T183","span":{"begin":1245,"end":1254},"obj":"Q25BC0"},{"id":"T184","span":{"begin":1245,"end":1254},"obj":"PR:000000017"},{"id":"T185","span":{"begin":1245,"end":1254},"obj":"P49708"},{"id":"T186","span":{"begin":1245,"end":1254},"obj":"Q865W6"},{"id":"T187","span":{"begin":1245,"end":1254},"obj":"O73915"},{"id":"T188","span":{"begin":1245,"end":1254},"obj":"Q62574"},{"id":"T189","span":{"begin":1245,"end":1254},"obj":"P28333"},{"id":"T190","span":{"begin":1245,"end":1254},"obj":"Q9QXX2"},{"id":"T191","span":{"begin":1245,"end":1254},"obj":"P01580"},{"id":"T192","span":{"begin":1245,"end":1254},"obj":"Q8MKF5"},{"id":"T193","span":{"begin":1245,"end":1254},"obj":"P01579"},{"id":"T194","span":{"begin":1245,"end":1254},"obj":"Q2PE75"},{"id":"T195","span":{"begin":1245,"end":1254},"obj":"Q4ZH68"},{"id":"T196","span":{"begin":1245,"end":1254},"obj":"P30123"},{"id":"T197","span":{"begin":1245,"end":1254},"obj":"P42162"},{"id":"T198","span":{"begin":1245,"end":1254},"obj":"Q9TTB0"},{"id":"T199","span":{"begin":1245,"end":1254},"obj":"O57571"},{"id":"T200","span":{"begin":1245,"end":1254},"obj":"P79154"},{"id":"T201","span":{"begin":1245,"end":1254},"obj":"O77763"},{"id":"T202","span":{"begin":1245,"end":1254},"obj":"Q866Y6"},{"id":"T203","span":{"begin":1245,"end":1254},"obj":"O57608"},{"id":"T204","span":{"begin":1245,"end":1254},"obj":"Q5CCK0"},{"id":"T205","span":{"begin":1245,"end":1254},"obj":"P63310"},{"id":"T206","span":{"begin":1245,"end":1254},"obj":"Q865Y4"},{"id":"T207","span":{"begin":1245,"end":1254},"obj":"P17773"},{"id":"T208","span":{"begin":1245,"end":1254},"obj":"Q5I6S9"},{"id":"T209","span":{"begin":1245,"end":1254},"obj":"Q8SPW9"},{"id":"T210","span":{"begin":1245,"end":1254},"obj":"Q9TV67"},{"id":"T211","span":{"begin":1245,"end":1254},"obj":"P42161"},{"id":"T212","span":{"begin":1245,"end":1254},"obj":"P17803"},{"id":"T213","span":{"begin":1245,"end":1254},"obj":"Q9YGB9"},{"id":"T214","span":{"begin":1245,"end":1254},"obj":"P01581"},{"id":"T215","span":{"begin":1245,"end":1254},"obj":"Q1WM28"},{"id":"T216","span":{"begin":1245,"end":1254},"obj":"Q647G2"},{"id":"T217","span":{"begin":1245,"end":1254},"obj":"P42160"},{"id":"T218","span":{"begin":1245,"end":1254},"obj":"O35735"},{"id":"T219","span":{"begin":1245,"end":1254},"obj":"Q865X1"},{"id":"T220","span":{"begin":1245,"end":1254},"obj":"P63309"},{"id":"T221","span":{"begin":1245,"end":1254},"obj":"P63311"},{"id":"T222","span":{"begin":1245,"end":1254},"obj":"O35497"},{"id":"T223","span":{"begin":1249,"end":1254},"obj":"CHEBI:30212"},{"id":"T224","span":{"begin":1249,"end":1254},"obj":"P12799"},{"id":"T225","span":{"begin":1293,"end":1303},"obj":"CL:0000542"},{"id":"T226","span":{"begin":1327,"end":1332},"obj":"PR:Q9Y653"},{"id":"T227","span":{"begin":1327,"end":1332},"obj":"9606"},{"id":"T228","span":{"begin":1327,"end":1332},"obj":"D006801"},{"id":"T229","span":{"begin":1333,"end":1341},"obj":"CL:0000576"},{"id":"T230","span":{"begin":1333,"end":1341},"obj":"CL:0001054"},{"id":"T231","span":{"begin":1369,"end":1377},"obj":"GO:0019815"},{"id":"T232","span":{"begin":1369,"end":1377},"obj":"GO:0042571"},{"id":"T233","span":{"begin":1369,"end":1377},"obj":"GO:0003823"},{"id":"T234","span":{"begin":1399,"end":1402},"obj":"PR:Q719N3"},{"id":"T235","span":{"begin":1399,"end":1402},"obj":"PR:000010045"},{"id":"T236","span":{"begin":1399,"end":1402},"obj":"CVCL_R844"},{"id":"T237","span":{"begin":1399,"end":1402},"obj":"Q719N3"},{"id":"T238","span":{"begin":1424,"end":1433},"obj":"Q7TSP4"},{"id":"T239","span":{"begin":1424,"end":1433},"obj":"P28341"},{"id":"T240","span":{"begin":1424,"end":1433},"obj":"P46402"},{"id":"T241","span":{"begin":1424,"end":1433},"obj":"O57603"},{"id":"T242","span":{"begin":1424,"end":1433},"obj":"P07353"},{"id":"T243","span":{"begin":1424,"end":1433},"obj":"A4PIZ9"},{"id":"T244","span":{"begin":1424,"end":1433},"obj":"Q25BC0"},{"id":"T245","span":{"begin":1424,"end":1433},"obj":"PR:000000017"},{"id":"T246","span":{"begin":1424,"end":1433},"obj":"P49708"},{"id":"T247","span":{"begin":1424,"end":1433},"obj":"Q865W6"},{"id":"T248","span":{"begin":1424,"end":1433},"obj":"O73915"},{"id":"T249","span":{"begin":1424,"end":1433},"obj":"Q62574"},{"id":"T250","span":{"begin":1424,"end":1433},"obj":"P28333"},{"id":"T251","span":{"begin":1424,"end":1433},"obj":"Q9QXX2"},{"id":"T252","span":{"begin":1424,"end":1433},"obj":"P01580"},{"id":"T253","span":{"begin":1424,"end":1433},"obj":"Q8MKF5"},{"id":"T254","span":{"begin":1424,"end":1433},"obj":"P01579"},{"id":"T255","span":{"begin":1424,"end":1433},"obj":"Q2PE75"},{"id":"T256","span":{"begin":1424,"end":1433},"obj":"Q4ZH68"},{"id":"T257","span":{"begin":1424,"end":1433},"obj":"P30123"},{"id":"T258","span":{"begin":1424,"end":1433},"obj":"P42162"},{"id":"T259","span":{"begin":1424,"end":1433},"obj":"Q9TTB0"},{"id":"T260","span":{"begin":1424,"end":1433},"obj":"O57571"},{"id":"T261","span":{"begin":1424,"end":1433},"obj":"P79154"},{"id":"T262","span":{"begin":1424,"end":1433},"obj":"O77763"},{"id":"T263","span":{"begin":1424,"end":1433},"obj":"Q866Y6"},{"id":"T264","span":{"begin":1424,"end":1433},"obj":"O57608"},{"id":"T265","span":{"begin":1424,"end":1433},"obj":"Q5CCK0"},{"id":"T266","span":{"begin":1424,"end":1433},"obj":"P63310"},{"id":"T267","span":{"begin":1424,"end":1433},"obj":"Q865Y4"},{"id":"T268","span":{"begin":1424,"end":1433},"obj":"P17773"},{"id":"T269","span":{"begin":1424,"end":1433},"obj":"Q5I6S9"},{"id":"T270","span":{"begin":1424,"end":1433},"obj":"Q8SPW9"},{"id":"T271","span":{"begin":1424,"end":1433},"obj":"Q9TV67"},{"id":"T272","span":{"begin":1424,"end":1433},"obj":"P42161"},{"id":"T273","span":{"begin":1424,"end":1433},"obj":"P17803"},{"id":"T274","span":{"begin":1424,"end":1433},"obj":"Q9YGB9"},{"id":"T275","span":{"begin":1424,"end":1433},"obj":"P01581"},{"id":"T276","span":{"begin":1424,"end":1433},"obj":"Q1WM28"},{"id":"T277","span":{"begin":1424,"end":1433},"obj":"Q647G2"},{"id":"T278","span":{"begin":1424,"end":1433},"obj":"P42160"},{"id":"T279","span":{"begin":1424,"end":1433},"obj":"O35735"},{"id":"T280","span":{"begin":1424,"end":1433},"obj":"Q865X1"},{"id":"T281","span":{"begin":1424,"end":1433},"obj":"P63309"},{"id":"T282","span":{"begin":1424,"end":1433},"obj":"P63311"},{"id":"T283","span":{"begin":1424,"end":1433},"obj":"O35497"},{"id":"T284","span":{"begin":1428,"end":1433},"obj":"CHEBI:30212"},{"id":"T285","span":{"begin":1428,"end":1433},"obj":"P12799"},{"id":"T286","span":{"begin":1442,"end":1447},"obj":"CHEBI:30216"},{"id":"T287","span":{"begin":1442,"end":1458},"obj":"D016898"},{"id":"T288","span":{"begin":1448,"end":1458},"obj":"P51527"},{"id":"T289","span":{"begin":1448,"end":1458},"obj":"D007372"},{"id":"T290","span":{"begin":1448,"end":1458},"obj":"P51526"},{"id":"T291","span":{"begin":1448,"end":1458},"obj":"CHEBI:52999"},{"id":"T292","span":{"begin":1479,"end":1482},"obj":"PR:Q719N3"},{"id":"T293","span":{"begin":1479,"end":1482},"obj":"PR:000010045"},{"id":"T294","span":{"begin":1479,"end":1482},"obj":"CVCL_R844"},{"id":"T295","span":{"begin":1479,"end":1482},"obj":"Q719N3"},{"id":"T296","span":{"begin":1505,"end":1515},"obj":"CL:0000542"},{"id":"T297","span":{"begin":1533,"end":1542},"obj":"Q7TSP4"},{"id":"T298","span":{"begin":1533,"end":1542},"obj":"P28341"},{"id":"T299","span":{"begin":1533,"end":1542},"obj":"P46402"},{"id":"T300","span":{"begin":1533,"end":1542},"obj":"O57603"},{"id":"T301","span":{"begin":1533,"end":1542},"obj":"P07353"},{"id":"T302","span":{"begin":1533,"end":1542},"obj":"A4PIZ9"},{"id":"T303","span":{"begin":1533,"end":1542},"obj":"Q25BC0"},{"id":"T304","span":{"begin":1533,"end":1542},"obj":"PR:000000017"},{"id":"T305","span":{"begin":1533,"end":1542},"obj":"P49708"},{"id":"T306","span":{"begin":1533,"end":1542},"obj":"Q865W6"},{"id":"T307","span":{"begin":1533,"end":1542},"obj":"O73915"},{"id":"T308","span":{"begin":1533,"end":1542},"obj":"Q62574"},{"id":"T309","span":{"begin":1533,"end":1542},"obj":"P28333"},{"id":"T310","span":{"begin":1533,"end":1542},"obj":"Q9QXX2"},{"id":"T311","span":{"begin":1533,"end":1542},"obj":"P01580"},{"id":"T312","span":{"begin":1533,"end":1542},"obj":"Q8MKF5"},{"id":"T313","span":{"begin":1533,"end":1542},"obj":"P01579"},{"id":"T314","span":{"begin":1533,"end":1542},"obj":"Q2PE75"},{"id":"T315","span":{"begin":1533,"end":1542},"obj":"Q4ZH68"},{"id":"T316","span":{"begin":1533,"end":1542},"obj":"P30123"},{"id":"T317","span":{"begin":1533,"end":1542},"obj":"P42162"},{"id":"T318","span":{"begin":1533,"end":1542},"obj":"Q9TTB0"},{"id":"T319","span":{"begin":1533,"end":1542},"obj":"O57571"},{"id":"T320","span":{"begin":1533,"end":1542},"obj":"P79154"},{"id":"T321","span":{"begin":1533,"end":1542},"obj":"O77763"},{"id":"T322","span":{"begin":1533,"end":1542},"obj":"Q866Y6"},{"id":"T323","span":{"begin":1533,"end":1542},"obj":"O57608"},{"id":"T324","span":{"begin":1533,"end":1542},"obj":"Q5CCK0"},{"id":"T325","span":{"begin":1533,"end":1542},"obj":"P63310"},{"id":"T326","span":{"begin":1533,"end":1542},"obj":"Q865Y4"},{"id":"T327","span":{"begin":1533,"end":1542},"obj":"P17773"},{"id":"T328","span":{"begin":1533,"end":1542},"obj":"Q5I6S9"},{"id":"T329","span":{"begin":1533,"end":1542},"obj":"Q8SPW9"},{"id":"T330","span":{"begin":1533,"end":1542},"obj":"Q9TV67"},{"id":"T331","span":{"begin":1533,"end":1542},"obj":"P42161"},{"id":"T332","span":{"begin":1533,"end":1542},"obj":"P17803"},{"id":"T333","span":{"begin":1533,"end":1542},"obj":"Q9YGB9"},{"id":"T334","span":{"begin":1533,"end":1542},"obj":"P01581"},{"id":"T335","span":{"begin":1533,"end":1542},"obj":"Q1WM28"},{"id":"T336","span":{"begin":1533,"end":1542},"obj":"Q647G2"},{"id":"T337","span":{"begin":1533,"end":1542},"obj":"P42160"},{"id":"T338","span":{"begin":1533,"end":1542},"obj":"O35735"},{"id":"T339","span":{"begin":1533,"end":1542},"obj":"Q865X1"},{"id":"T340","span":{"begin":1533,"end":1542},"obj":"P63309"},{"id":"T341","span":{"begin":1533,"end":1542},"obj":"P63311"},{"id":"T342","span":{"begin":1533,"end":1542},"obj":"O35497"},{"id":"T343","span":{"begin":1537,"end":1542},"obj":"CHEBI:30212"},{"id":"T344","span":{"begin":1537,"end":1542},"obj":"P12799"},{"id":"T345","span":{"begin":1573,"end":1576},"obj":"PR:Q719N3"},{"id":"T346","span":{"begin":1573,"end":1576},"obj":"PR:000010045"},{"id":"T347","span":{"begin":1573,"end":1576},"obj":"CVCL_R844"},{"id":"T348","span":{"begin":1573,"end":1576},"obj":"Q719N3"},{"id":"T349","span":{"begin":1590,"end":1599},"obj":"Q7TSP4"},{"id":"T350","span":{"begin":1590,"end":1599},"obj":"P28341"},{"id":"T351","span":{"begin":1590,"end":1599},"obj":"P46402"},{"id":"T352","span":{"begin":1590,"end":1599},"obj":"O57603"},{"id":"T353","span":{"begin":1590,"end":1599},"obj":"P07353"},{"id":"T354","span":{"begin":1590,"end":1599},"obj":"A4PIZ9"},{"id":"T355","span":{"begin":1590,"end":1599},"obj":"Q25BC0"},{"id":"T356","span":{"begin":1590,"end":1599},"obj":"PR:000000017"},{"id":"T357","span":{"begin":1590,"end":1599},"obj":"P49708"},{"id":"T358","span":{"begin":1590,"end":1599},"obj":"Q865W6"},{"id":"T359","span":{"begin":1590,"end":1599},"obj":"O73915"},{"id":"T360","span":{"begin":1590,"end":1599},"obj":"Q62574"},{"id":"T361","span":{"begin":1590,"end":1599},"obj":"P28333"},{"id":"T362","span":{"begin":1590,"end":1599},"obj":"Q9QXX2"},{"id":"T363","span":{"begin":1590,"end":1599},"obj":"P01580"},{"id":"T364","span":{"begin":1590,"end":1599},"obj":"Q8MKF5"},{"id":"T365","span":{"begin":1590,"end":1599},"obj":"P01579"},{"id":"T366","span":{"begin":1590,"end":1599},"obj":"Q2PE75"},{"id":"T367","span":{"begin":1590,"end":1599},"obj":"Q4ZH68"},{"id":"T368","span":{"begin":1590,"end":1599},"obj":"P30123"},{"id":"T369","span":{"begin":1590,"end":1599},"obj":"P42162"},{"id":"T370","span":{"begin":1590,"end":1599},"obj":"Q9TTB0"},{"id":"T371","span":{"begin":1590,"end":1599},"obj":"O57571"},{"id":"T372","span":{"begin":1590,"end":1599},"obj":"P79154"},{"id":"T373","span":{"begin":1590,"end":1599},"obj":"O77763"},{"id":"T374","span":{"begin":1590,"end":1599},"obj":"Q866Y6"},{"id":"T375","span":{"begin":1590,"end":1599},"obj":"O57608"},{"id":"T376","span":{"begin":1590,"end":1599},"obj":"Q5CCK0"},{"id":"T377","span":{"begin":1590,"end":1599},"obj":"P63310"},{"id":"T378","span":{"begin":1590,"end":1599},"obj":"Q865Y4"},{"id":"T379","span":{"begin":1590,"end":1599},"obj":"P17773"},{"id":"T380","span":{"begin":1590,"end":1599},"obj":"Q5I6S9"},{"id":"T381","span":{"begin":1590,"end":1599},"obj":"Q8SPW9"},{"id":"T382","span":{"begin":1590,"end":1599},"obj":"Q9TV67"},{"id":"T383","span":{"begin":1590,"end":1599},"obj":"P42161"},{"id":"T384","span":{"begin":1590,"end":1599},"obj":"P17803"},{"id":"T385","span":{"begin":1590,"end":1599},"obj":"Q9YGB9"},{"id":"T386","span":{"begin":1590,"end":1599},"obj":"P01581"},{"id":"T387","span":{"begin":1590,"end":1599},"obj":"Q1WM28"},{"id":"T388","span":{"begin":1590,"end":1599},"obj":"Q647G2"},{"id":"T389","span":{"begin":1590,"end":1599},"obj":"P42160"},{"id":"T390","span":{"begin":1590,"end":1599},"obj":"O35735"},{"id":"T391","span":{"begin":1590,"end":1599},"obj":"Q865X1"},{"id":"T392","span":{"begin":1590,"end":1599},"obj":"P63309"},{"id":"T393","span":{"begin":1590,"end":1599},"obj":"P63311"},{"id":"T394","span":{"begin":1590,"end":1599},"obj":"O35497"},{"id":"T395","span":{"begin":1594,"end":1599},"obj":"CHEBI:30212"},{"id":"T396","span":{"begin":1594,"end":1599},"obj":"P12799"},{"id":"T397","span":{"begin":1615,"end":1625},"obj":"CL:0000542"},{"id":"T398","span":{"begin":1667,"end":1677},"obj":"CL:0000542"},{"id":"T399","span":{"begin":1695,"end":1704},"obj":"Q7TSP4"},{"id":"T400","span":{"begin":1695,"end":1704},"obj":"P28341"},{"id":"T401","span":{"begin":1695,"end":1704},"obj":"P46402"},{"id":"T402","span":{"begin":1695,"end":1704},"obj":"O57603"},{"id":"T403","span":{"begin":1695,"end":1704},"obj":"P07353"},{"id":"T404","span":{"begin":1695,"end":1704},"obj":"A4PIZ9"},{"id":"T405","span":{"begin":1695,"end":1704},"obj":"Q25BC0"},{"id":"T406","span":{"begin":1695,"end":1704},"obj":"PR:000000017"},{"id":"T407","span":{"begin":1695,"end":1704},"obj":"P49708"},{"id":"T408","span":{"begin":1695,"end":1704},"obj":"Q865W6"},{"id":"T409","span":{"begin":1695,"end":1704},"obj":"O73915"},{"id":"T410","span":{"begin":1695,"end":1704},"obj":"Q62574"},{"id":"T411","span":{"begin":1695,"end":1704},"obj":"P28333"},{"id":"T412","span":{"begin":1695,"end":1704},"obj":"Q9QXX2"},{"id":"T413","span":{"begin":1695,"end":1704},"obj":"P01580"},{"id":"T414","span":{"begin":1695,"end":1704},"obj":"Q8MKF5"},{"id":"T415","span":{"begin":1695,"end":1704},"obj":"P01579"},{"id":"T416","span":{"begin":1695,"end":1704},"obj":"Q2PE75"},{"id":"T417","span":{"begin":1695,"end":1704},"obj":"Q4ZH68"},{"id":"T418","span":{"begin":1695,"end":1704},"obj":"P30123"},{"id":"T419","span":{"begin":1695,"end":1704},"obj":"P42162"},{"id":"T420","span":{"begin":1695,"end":1704},"obj":"Q9TTB0"},{"id":"T421","span":{"begin":1695,"end":1704},"obj":"O57571"},{"id":"T422","span":{"begin":1695,"end":1704},"obj":"P79154"},{"id":"T423","span":{"begin":1695,"end":1704},"obj":"O77763"},{"id":"T424","span":{"begin":1695,"end":1704},"obj":"Q866Y6"},{"id":"T425","span":{"begin":1695,"end":1704},"obj":"O57608"},{"id":"T426","span":{"begin":1695,"end":1704},"obj":"Q5CCK0"},{"id":"T427","span":{"begin":1695,"end":1704},"obj":"P63310"},{"id":"T428","span":{"begin":1695,"end":1704},"obj":"Q865Y4"},{"id":"T429","span":{"begin":1695,"end":1704},"obj":"P17773"},{"id":"T430","span":{"begin":1695,"end":1704},"obj":"Q5I6S9"},{"id":"T431","span":{"begin":1695,"end":1704},"obj":"Q8SPW9"},{"id":"T432","span":{"begin":1695,"end":1704},"obj":"Q9TV67"},{"id":"T433","span":{"begin":1695,"end":1704},"obj":"P42161"},{"id":"T434","span":{"begin":1695,"end":1704},"obj":"P17803"},{"id":"T435","span":{"begin":1695,"end":1704},"obj":"Q9YGB9"},{"id":"T436","span":{"begin":1695,"end":1704},"obj":"P01581"},{"id":"T437","span":{"begin":1695,"end":1704},"obj":"Q1WM28"},{"id":"T438","span":{"begin":1695,"end":1704},"obj":"Q647G2"},{"id":"T439","span":{"begin":1695,"end":1704},"obj":"P42160"},{"id":"T440","span":{"begin":1695,"end":1704},"obj":"O35735"},{"id":"T441","span":{"begin":1695,"end":1704},"obj":"Q865X1"},{"id":"T442","span":{"begin":1695,"end":1704},"obj":"P63309"},{"id":"T443","span":{"begin":1695,"end":1704},"obj":"P63311"},{"id":"T444","span":{"begin":1695,"end":1704},"obj":"O35497"},{"id":"T445","span":{"begin":1699,"end":1704},"obj":"CHEBI:30212"},{"id":"T446","span":{"begin":1699,"end":1704},"obj":"P12799"},{"id":"T447","span":{"begin":1726,"end":1729},"obj":"PR:Q719N3"},{"id":"T448","span":{"begin":1726,"end":1729},"obj":"PR:000010045"},{"id":"T449","span":{"begin":1726,"end":1729},"obj":"CVCL_R844"},{"id":"T450","span":{"begin":1726,"end":1729},"obj":"Q719N3"},{"id":"T451","span":{"begin":1748,"end":1756},"obj":"CHEBI:35224"},{"id":"T452","span":{"begin":1816,"end":1829},"obj":"D003907"},{"id":"T453","span":{"begin":1816,"end":1829},"obj":"CHEBI:41879"},{"id":"T454","span":{"begin":1904,"end":1911},"obj":"D000941"},{"id":"T455","span":{"begin":1904,"end":1911},"obj":"CHEBI:59132"},{"id":"T456","span":{"begin":1923,"end":1928},"obj":"PR:Q9Y653"},{"id":"T457","span":{"begin":1923,"end":1928},"obj":"9606"},{"id":"T458","span":{"begin":1923,"end":1928},"obj":"D006801"},{"id":"T459","span":{"begin":1929,"end":1935},"obj":"CL:0000084"},{"id":"T460","span":{"begin":1931,"end":1935},"obj":"GO:0005623"},{"id":"T461","span":{"begin":1931,"end":1935},"obj":"CL:0000000"},{"id":"T462","span":{"begin":1981,"end":1984},"obj":"PR:Q719N3"},{"id":"T463","span":{"begin":1981,"end":1984},"obj":"PR:000010045"},{"id":"T464","span":{"begin":1981,"end":1984},"obj":"CVCL_R844"},{"id":"T465","span":{"begin":1981,"end":1984},"obj":"Q719N3"},{"id":"T466","span":{"begin":2068,"end":2077},"obj":"Q7TSP4"},{"id":"T467","span":{"begin":2068,"end":2077},"obj":"P28341"},{"id":"T468","span":{"begin":2068,"end":2077},"obj":"P46402"},{"id":"T469","span":{"begin":2068,"end":2077},"obj":"O57603"},{"id":"T470","span":{"begin":2068,"end":2077},"obj":"P07353"},{"id":"T471","span":{"begin":2068,"end":2077},"obj":"A4PIZ9"},{"id":"T472","span":{"begin":2068,"end":2077},"obj":"Q25BC0"},{"id":"T473","span":{"begin":2068,"end":2077},"obj":"PR:000000017"},{"id":"T474","span":{"begin":2068,"end":2077},"obj":"P49708"},{"id":"T475","span":{"begin":2068,"end":2077},"obj":"Q865W6"},{"id":"T476","span":{"begin":2068,"end":2077},"obj":"O73915"},{"id":"T477","span":{"begin":2068,"end":2077},"obj":"Q62574"},{"id":"T478","span":{"begin":2068,"end":2077},"obj":"P28333"},{"id":"T479","span":{"begin":2068,"end":2077},"obj":"Q9QXX2"},{"id":"T480","span":{"begin":2068,"end":2077},"obj":"P01580"},{"id":"T481","span":{"begin":2068,"end":2077},"obj":"Q8MKF5"},{"id":"T482","span":{"begin":2068,"end":2077},"obj":"P01579"},{"id":"T483","span":{"begin":2068,"end":2077},"obj":"Q2PE75"},{"id":"T484","span":{"begin":2068,"end":2077},"obj":"Q4ZH68"},{"id":"T485","span":{"begin":2068,"end":2077},"obj":"P30123"},{"id":"T486","span":{"begin":2068,"end":2077},"obj":"P42162"},{"id":"T487","span":{"begin":2068,"end":2077},"obj":"Q9TTB0"},{"id":"T488","span":{"begin":2068,"end":2077},"obj":"O57571"},{"id":"T489","span":{"begin":2068,"end":2077},"obj":"P79154"},{"id":"T490","span":{"begin":2068,"end":2077},"obj":"O77763"},{"id":"T491","span":{"begin":2068,"end":2077},"obj":"Q866Y6"},{"id":"T492","span":{"begin":2068,"end":2077},"obj":"O57608"},{"id":"T493","span":{"begin":2068,"end":2077},"obj":"Q5CCK0"},{"id":"T494","span":{"begin":2068,"end":2077},"obj":"P63310"},{"id":"T495","span":{"begin":2068,"end":2077},"obj":"Q865Y4"},{"id":"T496","span":{"begin":2068,"end":2077},"obj":"P17773"},{"id":"T497","span":{"begin":2068,"end":2077},"obj":"Q5I6S9"},{"id":"T498","span":{"begin":2068,"end":2077},"obj":"Q8SPW9"},{"id":"T499","span":{"begin":2068,"end":2077},"obj":"Q9TV67"},{"id":"T500","span":{"begin":2068,"end":2077},"obj":"P42161"},{"id":"T501","span":{"begin":2068,"end":2077},"obj":"P17803"},{"id":"T502","span":{"begin":2068,"end":2077},"obj":"Q9YGB9"},{"id":"T503","span":{"begin":2068,"end":2077},"obj":"P01581"},{"id":"T504","span":{"begin":2068,"end":2077},"obj":"Q1WM28"},{"id":"T505","span":{"begin":2068,"end":2077},"obj":"Q647G2"},{"id":"T506","span":{"begin":2068,"end":2077},"obj":"P42160"},{"id":"T507","span":{"begin":2068,"end":2077},"obj":"O35735"},{"id":"T508","span":{"begin":2068,"end":2077},"obj":"Q865X1"},{"id":"T509","span":{"begin":2068,"end":2077},"obj":"P63309"},{"id":"T510","span":{"begin":2068,"end":2077},"obj":"P63311"},{"id":"T511","span":{"begin":2068,"end":2077},"obj":"O35497"},{"id":"T512","span":{"begin":2072,"end":2077},"obj":"CHEBI:30212"},{"id":"T513","span":{"begin":2072,"end":2077},"obj":"P12799"},{"id":"T514","span":{"begin":2091,"end":2096},"obj":"PR:Q9Y653"},{"id":"T515","span":{"begin":2091,"end":2096},"obj":"9606"},{"id":"T516","span":{"begin":2091,"end":2096},"obj":"D006801"},{"id":"T517","span":{"begin":2128,"end":2136},"obj":"CL:0000576"},{"id":"T518","span":{"begin":2128,"end":2136},"obj":"CL:0001054"},{"id":"T519","span":{"begin":2137,"end":2147},"obj":"CL:0000235"}],"text":"Lymphocyte supernatant-induced human monocyte tumoricidal activity: dependence on the presence of gamma-interferon.\nRecently, gamma-interferon (IFN-gamma) has been shown to be have the capacity to activate macrophages in several murine and human systems. The studies reported here were undertaken to determine the identity of the lymphokine responsible for activation of human monocytes to a tumoricidal state. Macrophage-activating factor (MAF) activity was assessed using a 24-h 51Cr release assay with human monocytes as effector cells and K-562 targets. Stimulated lymphocyte supernatants were produced by stimulation of peripheral blood mononuclear cells with concanavalin A in serum-free media. Interferon was detected in an antiviral assay. Four lines of evidence lead to the conclusion that MAF and IFN-gamma are identical in this system: (a) fractionation of stimulated lymphocyte supernatants by adsorption chromatography, followed by anion or cation exchange chromatography (Mono-S, Mono-Q columns), resulted in nearly identical elution profiles of MAF and IFN activities. All of the individual fractions containing MAF activity were found to contain IFN in amounts corresponding to MAF activity. (b) Monoclonal antibody specific for IFN-gamma neutralized the ability of stimulated lymphocyte supernatants to induce human monocyte tumoricidal activity. This antibody also neutralized the MAF activity of purified IFN-gamma but not alpha-interferon. (c) The biological MAF activity of activated lymphocyte supernatants and IFN-gamma were similar. Dilution versus MAF activity for IFN-gamma and stimulated lymphocyte supernatants exhibited identical slopes. Lymphocyte supernatants and IFN-gamma demonstrated similar MAF activity on three effector cells: monocytes, in vitro-differentiated macrophages, and dexamethasone-differentiated macrophages. (d) Analysis of supernatants produced by five antigen-stimulated human T-cell clones demonstrated coordinate production of MAF and IFN. These results provide compelling evidence for support of the concept that IFN-gamma is the major human lymphokine capable of inducing monocyte-macrophage tumoricidal activity."}