PubMed:39134528
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 322-328 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/MAT_0000119 |
| T2 | 398-403 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T3 | 523-528 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T4 | 592-597 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T5 | 723-728 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T6 | 806-811 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T8 | 887-892 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T9 | 994-999 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 50-53 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 103-106 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 239-242 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T4 | 404-407 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T5 | 466-469 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T6 | 512-515 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T7 | 598-601 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T8 | 729-732 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T9 | 812-815 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T10 | 904-907 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T11 | 1000-1003 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 61-65 | OrganismTaxon | denotes | mice | 10088 |
| T2 | 663-667 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 37-46 | Body_part | denotes | excretion | http://purl.obolibrary.org/obo/UBERON_0000174 |
| T2 | 264-278 | Body_part | denotes | cell membranes | http://purl.obolibrary.org/obo/GO_0005886 |
| T3 | 322-328 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T4 | 340-355 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T5 | 398-403 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T6 | 523-528 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T7 | 592-597 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T8 | 723-728 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T9 | 806-811 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T10 | 887-892 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T11 | 897-903 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T12 | 994-999 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T13 | 1069-1078 | Body_part | denotes | excretion | http://purl.obolibrary.org/obo/UBERON_0000174 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 322-328 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/MAT_0000119 |
| T2 | 398-403 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T3 | 523-528 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T4 | 592-597 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T5 | 723-728 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T6 | 806-811 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T8 | 887-892 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T9 | 994-999 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-77 | Sentence | denotes | SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. |
| T2 | 78-188 | Sentence | denotes | N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. |
| T3 | 189-279 | Sentence | denotes | Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. |
| T4 | 280-425 | Sentence | denotes | Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carriers, as physiologic urine Lac-Phe transporters. |
| T5 | 426-490 | Sentence | denotes | In cell culture, SLC17A1/3 exhibit high Lac-Phe efflux activity. |
| T6 | 491-591 | Sentence | denotes | In humans, levels of Lac-Phe in urine exhibit a strong genetic association with the SLC17A1-4 locus. |
| T7 | 592-659 | Sentence | denotes | Urine Lac-Phe levels are increased following a Wingate sprint test. |
| T8 | 660-744 | Sentence | denotes | In mice, genetic ablation of either SLC17A1 or SLC17A3 reduces urine Lac-Phe levels. |
| T9 | 745-918 | Sentence | denotes | Despite these differences, both knockout strains have normal blood Lac-Phe and body weights, demonstrating SLC17A1/3-dependent de-coupling of urine and plasma Lac-Phe pools. |
| T10 | 919-1108 | Sentence | denotes | Together, these data establish SLC17A1/3 family members as the physiologic urine Lac-Phe transporters and uncover a biochemical pathway for the renal excretion of this signaling metabolite. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 50-53 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 103-106 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 239-242 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T4 | 404-407 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T5 | 466-469 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T6 | 512-515 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T7 | 598-601 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T8 | 729-732 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T9 | 812-815 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T10 | 904-907 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T11 | 1000-1003 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 61-65 | OrganismTaxon | denotes | mice | 10088 |
| T2 | 663-667 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 37-46 | Body_part | denotes | excretion | http://purl.obolibrary.org/obo/UBERON_0000174 |
| T2 | 264-278 | Body_part | denotes | cell membranes | http://purl.obolibrary.org/obo/GO_0005886 |
| T3 | 322-328 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T4 | 340-355 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T5 | 398-403 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T6 | 523-528 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T7 | 592-597 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T8 | 723-728 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T9 | 806-811 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T10 | 887-892 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T11 | 897-903 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T12 | 994-999 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T13 | 1069-1078 | Body_part | denotes | excretion | http://purl.obolibrary.org/obo/UBERON_0000174 |