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PubMed:39115362 JSONTXT

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Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 12-18 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 1109-1115 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 1195-1201 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T4 1617-1623 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 35-41 OrganismTaxon denotes bovine 9913
T2 444-450 OrganismTaxon denotes bovine 9913

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 99-108 Body_part denotes colostrum http://purl.obolibrary.org/obo/UBERON_0001914
T2 119-123 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T3 176-180 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T4 468-477 Body_part denotes colostrum http://purl.obolibrary.org/obo/UBERON_0001914
T5 482-486 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T6 1519-1528 Body_part denotes colostrum http://purl.obolibrary.org/obo/UBERON_0001914
T7 1539-1543 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes LacdiNAc to LacNAc: remodelling of bovine α-lactalbumin N-glycosylation during the transition from colostrum to mature milk.
T2 125-273 Sentence denotes α -Lactalbumin, an abundant protein present in the milk of most mammals, is associated with biological, nutritional and technological functionality.
T3 274-398 Sentence denotes Its sequence presents N-glycosylation motifs, the occupancy of which is species-specific, ranging from no to full occupancy.
T4 399-602 Sentence denotes Here, we investigated the N-glycosylation of bovine α-lactalbumin in colostrum and milk sampled from four individual cows, each at 9 time points starting from the day of calving up to 28.0 d post-partum.
T5 603-824 Sentence denotes Using a glycopeptide-centric mass spectrometry-based glycoproteomics approach, we identified N-glycosylation at both Asn residues found in the canonical Asn-Xxx-Ser/Thr motif, i.e. Asn45 and Asn74 of the secreted protein.
T6 825-965 Sentence denotes We found similar glycan profiles in all four cows, with partial site occupancies, averaging at 35% and 4% for Asn45 and Asn74, respectively.
T7 966-1041 Sentence denotes No substantial changes in occupancy occurred over lactation at either site.
T8 1042-1267 Sentence denotes Fucosylation, sialylation, primarily with N-acetylneuraminic acid (Neu5Ac), and a high ratio of N,N'-diacetyllactosamine (LacdiNAc)/N-acetyllactosamine (LacNAc) motifs were characteristic features of the identified N-glycans.
T9 1268-1677 Sentence denotes While no substantial changes occurred in site occupancy at either site during lactation, the glycoproteoform (i.e. glycosylated form of the protein) profile revealed dynamic changes; the maturation of the α-lactalbumin glycoproteoform repertoire from colostrum to mature milk was marked by substantial increases in neutral glycans and the number of LacNAc motifs per glycan, at the expense of LacdiNAc motifs.
T10 1678-1959 Sentence denotes While the implications of α-lactalbumin N-glycosylation on functionality are still unclear, we speculate that N-glycosylation at Asn74 results in a structurally and functionally different protein, due to competition with the formation of its two intra-molecular disulphide bridges.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 12-18 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 1109-1115 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 1195-1201 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T4 1617-1623 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 35-41 OrganismTaxon denotes bovine 9913
T2 444-450 OrganismTaxon denotes bovine 9913

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 99-108 Body_part denotes colostrum http://purl.obolibrary.org/obo/UBERON_0001914
T2 119-123 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T3 176-180 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T4 468-477 Body_part denotes colostrum http://purl.obolibrary.org/obo/UBERON_0001914
T5 482-486 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T6 1519-1528 Body_part denotes colostrum http://purl.obolibrary.org/obo/UBERON_0001914
T7 1539-1543 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913