PubMed:38844136
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 346-351 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 376-384 | Body_part | denotes | stemness | http://purl.obolibrary.org/obo/MAT_0000239 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 178-184 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 208-211 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T3 | 431-434 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T4 | 541-547 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T5 | 621-624 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T6 | 652-658 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T7 | 939-945 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 1158-1161 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T9 | 1166-1172 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T10 | 1201-1204 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T11 | 1343-1349 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T12 | 1436-1439 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T13 | 1489-1492 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T14 | 1689-1692 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T15 | 1775-1781 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1623-1645 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | human natural killer-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1623-1628 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 346-351 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 346-351 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 376-384 | Body_part | denotes | stemness | http://purl.obolibrary.org/obo/MAT_0000239 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-84 | Sentence | denotes | LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping. |
| T2 | 85-177 | Sentence | denotes | Structural variation of N-glycans is essential for the regulation of glycoprotein functions. |
| T3 | 178-385 | Sentence | denotes | GalNAcβ1-4GlcNAc (LacdiNAc or LDN), a unique subterminal glycan structure synthesized by B4GALNT3 or B4GALNT4, is involved in the clearance of N-glycoproteins from the blood and maintenance of cell stemness. |
| T4 | 386-549 | Sentence | denotes | Such regulation of glycoprotein functions by LDN is largely different from that by the dominant subterminal structure, N-acetyllactosamine (Galβ1-4GlcNAc, LacNAc). |
| T5 | 550-674 | Sentence | denotes | However, the mechanisms by which B4GALNT activity is regulated and how LDN plays different roles from LacNAc remain unclear. |
| T6 | 675-826 | Sentence | denotes | Here, we found that B4GALNT3 and four have unique domain organization containing a noncatalytic PA14 domain, which is a putative glycan-binding module. |
| T7 | 827-1073 | Sentence | denotes | A mutant lacking this domain dramatically decreases the activity toward various substrates, such as N-glycan, O-GalNAc glycan, and glycoproteins, indicating that this domain is essential for enzyme activity and forms part of the catalytic region. |
| T8 | 1074-1317 | Sentence | denotes | In addition, to clarify the mechanism underlying the functional differences between LDN and LacNAc, we examined the effects of LDN on the maturation of N-glycans, focusing on the related glycosyltransferases upstream and downstream of B4GALNT. |
| T9 | 1318-1462 | Sentence | denotes | We revealed that, unlike LacNAc synthesis, prior formation of bisecting GlcNAc in N-glycan almost completely inhibits LDN synthesis by B4GALNT3. |
| T10 | 1463-1656 | Sentence | denotes | Moreover, the presence of LDN negatively impacted the actions of many glycosyltransferases for terminal modifications, including sialylation, fucosylation, and human natural killer-1 synthesis. |
| T11 | 1657-1899 | Sentence | denotes | These findings demonstrate that LDN has significant impacts on N-glycan maturation in a completely different way from LacNAc, which could contribute to obtaining a comprehensive overview of the system regulating complex N-glycan biosynthesis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | glycosmos_id | image |
|---|---|---|---|---|---|---|
| T1 | 178-184 | Glycan | denotes | GalNAc | https://glycosmos.org/glycans/show/G39738WL | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 208-211 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T3 | 431-434 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T4 | 541-547 | Glycan | denotes | LacNAc | https://glycosmos.org/glycans/show/G66213AR | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T5 | 621-624 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T6 | 652-658 | Glycan | denotes | LacNAc | https://glycosmos.org/glycans/show/G66213AR | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T7 | 939-945 | Glycan | denotes | GalNAc | https://glycosmos.org/glycans/show/G39738WL | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 1158-1161 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T9 | 1166-1172 | Glycan | denotes | LacNAc | https://glycosmos.org/glycans/show/G66213AR | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T10 | 1201-1204 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T11 | 1343-1349 | Glycan | denotes | LacNAc | https://glycosmos.org/glycans/show/G66213AR | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T12 | 1436-1439 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T13 | 1489-1492 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T14 | 1689-1692 | Glycan | denotes | LDN | https://glycosmos.org/glycans/show/G31736BK | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T15 | 1775-1781 | Glycan | denotes | LacNAc | https://glycosmos.org/glycans/show/G66213AR | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1623-1645 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | human natural killer-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1623-1628 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 346-351 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |