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PubMed:38755139 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 61-71 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 206-216 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 245-260 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T4 472-482 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 615-630 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T6 817-827 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T7 1337-1347 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 377-383 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 1017-1023 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 1185-1191 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 377-383 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 1017-1023 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 1185-1191 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 946-951 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 797-805 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T2 1222-1226 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 61-71 Disease denotes SARS-CoV-2 MONDO:0100096
T2 206-216 Disease denotes SARS-CoV-2 MONDO:0100096
T3 245-260 Disease denotes viral infection MONDO:0005108
T4 472-482 Disease denotes SARS-CoV-2 MONDO:0100096
T5 615-630 Disease denotes viral infection MONDO:0005108
T6 817-827 Disease denotes SARS-CoV-2 MONDO:0100096
T7 1337-1347 Disease denotes SARS-CoV-2 MONDO:0100096

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 61-69 Organism denotes SARS-CoV 694009
T2 206-214 Organism denotes SARS-CoV 694009
T3 472-480 Organism denotes SARS-CoV 694009
T4 817-825 Organism denotes SARS-CoV 694009
T5 1042-1049 Organism denotes omicron 2613138
T6 1216-1221 Organism denotes human 9606
T7 1337-1345 Organism denotes SARS-CoV 694009

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.
T2 111-261 Sentence denotes The multibasic furin cleavage site at the S1/S2 boundary of the spike protein is a hallmark of SARS-CoV-2 and plays a crucial role in viral infection.
T3 262-357 Sentence denotes However, the mechanism underlying furin activation and its regulation remain poorly understood.
T4 358-631 Sentence denotes Here, we show that GalNAc-T3 and T7 jointly initiate clustered O-glycosylations in the furin cleavage site of the SARS-CoV-2 spike protein, which inhibit furin processing, suppress the incorporation of the spike protein into virus-like-particles and affect viral infection.
T5 632-882 Sentence denotes Mechanistic analysis reveals that the assembly of the spike protein into virus-like particles relies on interactions between the furin-cleaved spike protein and the membrane protein of SARS-CoV-2, suggesting a possible mechanism for furin activation.
T6 883-1034 Sentence denotes Interestingly, mutations in the spike protein of the alpha and delta variants of the virus confer resistance against glycosylation by GalNAc-T3 and T7.
T7 1035-1233 Sentence denotes In the omicron variant, additional mutations reverse this resistance, making the spike protein susceptible to glycosylation in vitro and sensitive to GalNAc-T3 and T7 expression in human lung cells.
T8 1234-1424 Sentence denotes Our findings highlight the role of glycosylation as a defense mechanism employed by host cells against SARS-CoV-2 and shed light on the evolutionary interplay between the host and the virus.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 1222-1226 Body_part denotes lung FMA:7195

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1222-1226 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 61-69 OrganismTaxon denotes SARS-CoV 694009
T2 206-214 OrganismTaxon denotes SARS-CoV 694009
T3 472-480 OrganismTaxon denotes SARS-CoV 694009
T4 817-825 OrganismTaxon denotes SARS-CoV 694009
T5 1042-1049 OrganismTaxon denotes omicron 2613138
T6 1216-1221 OrganismTaxon denotes human 9606
T7 1337-1345 OrganismTaxon denotes SARS-CoV 694009

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 797-805 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1222-1226 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1222-1226 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 946-951 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124