PubMed:38724577
Annnotations
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 953-961 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 1091-1099 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 1459-1467 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 953-961 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 1091-1099 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 1459-1467 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 78-82 | OrganismTaxon | denotes | rats | 10114|10116 |
| T3 | 115-120 | OrganismTaxon | denotes | human | 9606 |
| T4 | 570-574 | OrganismTaxon | denotes | rats | 10114|10116 |
| T6 | 1636-1640 | OrganismTaxon | denotes | rats | 10114|10116 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 884-889 | Body_part | denotes | Heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T5 | 891-896 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 901-906 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/UBERON_0000170 |
| T8 | 1231-1236 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T9 | 1247-1252 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 558-562 | Body_part | denotes | Male | http://purl.obolibrary.org/obo/MAT_0000029 |
| T2 | 884-889 | Body_part | denotes | Heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T3 | 891-896 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 901-906 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/MAT_0000135 |
| T5 | 1231-1236 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T7 | 1247-1252 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-83 | Sentence | denotes | O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats. |
| T2 | 84-179 | Sentence | denotes | Anaesthetics are used daily in human and veterinary medicine as well as in scientific research. |
| T3 | 180-302 | Sentence | denotes | Anaesthetics have an impact on cell homeostasis especially through modulation of protein post-translational modifications. |
| T4 | 303-408 | Sentence | denotes | O-GlcNAcylation, a ubiquitous post-translational modification, plays a role in many biological processes. |
| T5 | 409-557 | Sentence | denotes | The aims of this study were to evaluate whether (1) anaesthesia influences O-GlcNAcylation and (2) its stimulation affects physiological parameters. |
| T6 | 558-640 | Sentence | denotes | Male Wistar rats (n = 38) were anaesthetized with ketamine-xylazine or isoflurane. |
| T7 | 641-780 | Sentence | denotes | They randomly received either an intravenous injection of Ringer's lactate or NButGT (10mg/kg) in order to increase O-GlcNAcylation levels. |
| T8 | 781-883 | Sentence | denotes | One hour after induction of anaesthesia, haemodynamic parameters and plasmatic markers were evaluated. |
| T9 | 884-1009 | Sentence | denotes | Heart, brain and lungs were harvested and O-GlcNAcylation levels and O-GlcNAc-related enzymes were evaluated by western blot. |
| T10 | 1010-1164 | Sentence | denotes | Cardiac and pulmonary O-GlcNAcylation levels and cardiac, cerebral and pulmonary O-GlcNAc associated enzyme expression were not impacted with anaesthesia. |
| T11 | 1165-1272 | Sentence | denotes | Compared with ketamine-xylazine, isoflurane had a lower impact on blood pressure, heart rate and glycaemia. |
| T12 | 1273-1374 | Sentence | denotes | Pharmacological stimulation of O-GlcNAcylation by NButGT did not affect the physiological parameters. |
| T13 | 1375-1503 | Sentence | denotes | This study offers unprecedented insights into the regulation of O-GlcNAcylation and O-GlcNAc related enzymes during anaesthesia. |
| T14 | 1504-1641 | Sentence | denotes | Pharmacological stimulation of O-GlcNAcylation over a 1-h period did not disrupt the physiological balance in healthy anaesthetized rats. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 953-961 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 1091-1099 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 1459-1467 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 953-961 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 1091-1099 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 1459-1467 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 78-82 | OrganismTaxon | denotes | rats | 10114|10116 |
| T3 | 115-120 | OrganismTaxon | denotes | human | 9606 |
| T4 | 570-574 | OrganismTaxon | denotes | rats | 10114|10116 |
| T6 | 1636-1640 | OrganismTaxon | denotes | rats | 10114|10116 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 558-562 | Body_part | denotes | Male | http://purl.obolibrary.org/obo/MAT_0000029 |
| T2 | 884-889 | Body_part | denotes | Heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T3 | 891-896 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 901-906 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/MAT_0000135 |
| T5 | 1231-1236 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T7 | 1247-1252 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 884-889 | Body_part | denotes | Heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T5 | 891-896 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 901-906 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/UBERON_0000170 |
| T8 | 1231-1236 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T9 | 1247-1252 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |