PubMed:38642280
Annnotations
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1257-1268 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 418-433 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T3 | 435-437 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T4 | 613-615 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T5 | 824-826 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T7 | 1692-1694 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 77-87 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T2 | 113-160 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 162-172 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T4 | 197-205 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T5 | 398-408 | Disease | denotes | SARS‑CoV‑2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 1076-1086 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 2029-2039 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1257-1268 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 418-433 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T2 | 435-437 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T3 | 613-615 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T4 | 824-826 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T6 | 1692-1694 | Glycan | denotes | HS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 746-755 | Body_part | denotes | organisms | http://purl.obolibrary.org/obo/UBERON_0000468 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 77-87 | Disease | denotes | SARS-CoV-2 | MONDO:0100096 |
| T2 | 113-160 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | MONDO:0100096 |
| T3 | 162-172 | Disease | denotes | SARS-CoV-2 | MONDO:0100096 |
| T4 | 197-205 | Disease | denotes | COVID-19 | MONDO:0100096 |
| T5 | 398-408 | Disease | denotes | SARS‑CoV‑2 | MONDO:0100096 |
| T6 | 1076-1086 | Disease | denotes | SARS-CoV-2 | MONDO:0100096 |
| T7 | 2029-2039 | Disease | denotes | SARS-CoV-2 | MONDO:0100096 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 418-433 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 435-437 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 613-615 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 824-826 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 1257-1268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T6 | 1692-1694 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 77-85 | Organism | denotes | SARS-CoV | 694009 |
| T2 | 88-95 | Organism | denotes | Omicron | 2613138 |
| T3 | 113-146 | Organism | denotes | severe acute respiratory syndrome | 694009 |
| T4 | 162-170 | Organism | denotes | SARS-CoV | 694009 |
| T5 | 398-406 | Organism | denotes | SARS‑CoV | 694009 |
| T6 | 1076-1084 | Organism | denotes | SARS-CoV | 694009 |
| T7 | 1313-1322 | Organism | denotes | cucumbers | 3659 |
| T8 | 1324-1334 | Organism | denotes | sea urchin | 7625 |
| T9 | 1347-1366 | Organism | denotes | Saccharina japonica | 88149 |
| T10 | 2029-2037 | Organism | denotes | SARS-CoV | 694009 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-108 | Sentence | denotes | Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variant. |
| T2 | 109-246 | Sentence | denotes | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide COVID-19 pandemic, leading to 6.8 million deaths. |
| T3 | 247-369 | Sentence | denotes | Numerous variants have emerged since its outbreak, resulting in its significantly enhanced ability to spread among humans. |
| T4 | 370-577 | Sentence | denotes | As with many other viruses, SARS‑CoV‑2 utilizes heparan sulfate (HS) glycosaminoglycan (GAG) on the surface of host cells to facilitate viral attachment and initiate cellular entry through the ACE2 receptor. |
| T5 | 578-708 | Sentence | denotes | Therefore, interfering with virion-HS interactions represents a promising target to develop broad-spectrum antiviral therapeutics. |
| T6 | 709-978 | Sentence | denotes | Sulfated glycans derived from marine organisms have been proven to be exceptional reservoirs of naturally existing HS mimetics, which exhibit remarkable therapeutic properties encompassing antiviral/microbial, antitumor, anticoagulant, and anti-inflammatory activities. |
| T7 | 979-1381 | Sentence | denotes | In the current study, the interactions between the receptor-binding domain (RBD) of S-protein of SARS-CoV-2 (both WT and XBB.1.5 variants) and heparin were applied to assess the inhibitory activity of 10 marine-sourced glycans including three sulfated fucans, three fucosylated chondroitin sulfates and two fucoidans derived from sea cucumbers, sea urchin and seaweed Saccharina japonica, respectively. |
| T8 | 1382-1556 | Sentence | denotes | The inhibitory activity of these marine derived sulfated glycans on the interactions between RBD of S-protein and heparin was evaluated using Surface Plasmon Resonance (SPR). |
| T9 | 1557-1695 | Sentence | denotes | The RBDs of S-proteins from both Omicrion XBB.1.5 and wild-type (WT) were found to bind to heparin, which is a highly sulfated form of HS. |
| T10 | 1696-1818 | Sentence | denotes | All the tested marine-sourced sulfated glycans exhibited strong inhibition of WT and XBB.1.5 S-protein binding to heparin. |
| T11 | 1819-2047 | Sentence | denotes | We believe the study on the molecular interactions between S-proteins and host cell glycosaminoglycans provides valuable insight for the development of marine-sourced, glycan-based inhibitors as potential anti-SARS-CoV-2 agents. |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 77-85 | OrganismTaxon | denotes | SARS-CoV | 694009 |
| T2 | 88-95 | OrganismTaxon | denotes | Omicron | 2613138 |
| T3 | 113-146 | OrganismTaxon | denotes | severe acute respiratory syndrome | 694009 |
| T4 | 162-170 | OrganismTaxon | denotes | SARS-CoV | 694009 |
| T5 | 398-406 | OrganismTaxon | denotes | SARS‑CoV | 694009 |
| T6 | 1076-1084 | OrganismTaxon | denotes | SARS-CoV | 694009 |
| T7 | 1313-1322 | OrganismTaxon | denotes | cucumbers | 3659 |
| T8 | 1324-1334 | OrganismTaxon | denotes | sea urchin | 7625 |
| T9 | 1347-1366 | OrganismTaxon | denotes | Saccharina japonica | 88149 |
| T10 | 2029-2037 | OrganismTaxon | denotes | SARS-CoV | 694009 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 418-433 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 435-437 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 613-615 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 824-826 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 1257-1268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T6 | 1692-1694 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 746-755 | Body_part | denotes | organisms | http://purl.obolibrary.org/obo/UBERON_0000468 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1055-1058 | Phenotype | denotes | RBD | HP:5200291 |
| T2 | 1475-1478 | Phenotype | denotes | RBD | HP:5200291 |