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PubMed:38582892 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 163-172 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 259-268 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 629-632 Disease denotes STD http://purl.obolibrary.org/obo/MONDO_0021681

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 403-409 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 714-720 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T3 976-982 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T4 1127-1133 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 163-172 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 259-268 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 629-632 Disease denotes STD http://purl.obolibrary.org/obo/MONDO_0021681

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 65-70 OrganismTaxon denotes human 9606
T2 157-162 OrganismTaxon denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling.
T2 132-227 Sentence denotes Prototypic receptors for human influenza viruses are N-glycans carrying α2,6-linked sialosides.
T3 228-418 Sentence denotes Due to immune pressure, A/H3N2 influenza viruses have emerged with altered receptor specificities that bind α2,6-linked sialosides presented on extended N-acetyl-lactosamine (LacNAc) chains.
T4 419-589 Sentence denotes Here, binding modes of such drifted hemagglutinin's (HAs) are examined by chemoenzymatic synthesis of N-glycans having 13C-labeled monosaccharides at strategic positions.
T5 590-767 Sentence denotes The labeled glycans are employed in 2D STD-1H by 13C-HSQC NMR experiments to pinpoint which monosaccharides of the extended LacNAc chain engage with evolutionarily distinct HAs.
T6 768-989 Sentence denotes The NMR data in combination with computation and mutagenesis demonstrate that mutations distal to the receptor binding domain of recent HAs create an extended binding site that accommodates with the extended LacNAc chain.
T7 990-1152 Sentence denotes A fluorine containing sialoside is used as NMR probe to derive relative binding affinities and confirms the contribution of the extended LacNAc chain for binding.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 403-409 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 714-720 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T3 976-982 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T4 1127-1133 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 65-70 OrganismTaxon denotes human 9606
T2 157-162 OrganismTaxon denotes human 9606