PubMed:384871 JSONTXT

{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":10,"end":26},"obj":"HP:0001138"},{"id":"AB1","span":{"begin":314,"end":321},"obj":"HP:0000575"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":314,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":532,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-nr-ng-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":276,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T11","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-nr-g-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-ng-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-g-experiment","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-m30","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":314,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":532,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-m20","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-nr-ng","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":276,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T11","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gemini-nr-ng","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gemini-r-g","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":303,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gemini-r-ng","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":314,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":532,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gemini-nr-g","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":292,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-nr-g","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-ng","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-nr-ng","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-g","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-r-ng","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gemini-r-m","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-m2","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-r-g","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-nr-g","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":235,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T8","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T9","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T10","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T11","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-deepseek-r-m","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":520,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}

{"project":"bc5cdr-valid-gpt-r-m","denotations":[{"id":"T1","span":{"begin":10,"end":26},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":53},"obj":"Chemical"},{"id":"T3","span":{"begin":58,"end":67},"obj":"Chemical"},{"id":"T4","span":{"begin":195,"end":205},"obj":"Chemical"},{"id":"T5","span":{"begin":210,"end":219},"obj":"Chemical"},{"id":"T6","span":{"begin":245,"end":267},"obj":"Disease"},{"id":"T7","span":{"begin":284,"end":321},"obj":"Disease"},{"id":"T8","span":{"begin":333,"end":343},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":423},"obj":"Chemical"},{"id":"T10","span":{"begin":532,"end":540},"obj":"Disease"},{"id":"T11","span":{"begin":548,"end":558},"obj":"Chemical"},{"id":"T12","span":{"begin":618,"end":628},"obj":"Chemical"},{"id":"T13","span":{"begin":633,"end":642},"obj":"Chemical"}],"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.\nThe case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid."}