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PubMed:3838173 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 36-39 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 227-230 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 267-278 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 482-485 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T8 537-540 Glycan_Motif denotes GM2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC
T10 759-762 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T12 774-797 Glycan_Motif denotes N-acetylneuraminic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T14 1002-1005 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T16 1075-1078 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T18 1155-1158 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T20 1294-1297 Glycan_Motif denotes GM2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC
T22 1511-1514 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T24 1672-1695 Glycan_Motif denotes N-acetylneuraminic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T26 1707-1710 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes N-Acetylneuraminyllactosylceramide, GM3-NeuAc, a new influenza A virus receptor which mediates the adsorption-fusion process of viral infection.
T2 145-279 Sentence denotes Binding specificity of influenza virus A/Aichi/2/68 (H3N2) to membrane-associated GM3 with different molecular species of sialic acid.
T3 280-458 Sentence denotes Agglutinates of native chicken erythrocytes caused by influenza virus A/Aichi/2/68 (H3N2) at 4 degrees C were potently fused and lysed at low pH (optimum pH 5.3) at 37 degrees C.
T4 459-711 Sentence denotes Exogenous gangliosides GM3 (Sia alpha 2-3Gal beta 1-4Glc beta 1-ceramide) and GM2 (GalNAc beta 1-4(Sia alpha 2-3)-Gal beta 1-4Glc beta 1-ceramide) were integrated into the membranes of chicken asialoerythrocytes within 5-min incubation at 37 degrees C.
T5 712-972 Sentence denotes We found that the incorporation of ganglioside GM3 containing N-acetylneuraminic acid into asialoerythrocytes restored the biological responsiveness to the virus as established by agglutination at 4 degrees C and fusion and hemolysis at 37 degrees C at pH 5.3.
T6 973-1137 Sentence denotes Biological responsiveness of GM3-NeuAc-erythrocytes to the virus was considerably higher than that of GM3-NeuGc-erythrocytes under the same experimental conditions.
T7 1138-1269 Sentence denotes Treatment of the GM3-NeuAc-erythrocytes with neuraminidase again resulted in the complete abolishment of the response to the virus.
T8 1270-1363 Sentence denotes Erythrocytes containing GM2-NeuAc showed no detectable biological responses toward the virus.
T9 1364-1769 Sentence denotes The above results indicate that the hemagglutinin of influenza virus A/Aichi/2/68 (H3N2) recognizes the sialyloligosaccharide chain of ganglioside GM3 as its receptor which mediates the adsorption and fusion process on the virus entry into the host cells and has more preferential specificity for binding to N-acetylneuraminic acid-containing GM3 than that to N-glycolyl type in the target cell membranes.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 36-39 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 36-39 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 227-230 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 227-230 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 267-278 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 482-485 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T7 482-485 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T8 537-540 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T9 537-540 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T10 759-762 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T11 759-762 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T12 774-797 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T13 774-797 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T14 1002-1005 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T15 1002-1005 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T16 1075-1078 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T17 1075-1078 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T18 1155-1158 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T19 1155-1158 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T20 1294-1297 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T21 1294-1297 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T22 1511-1514 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T23 1511-1514 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T24 1672-1695 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T25 1672-1695 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T26 1707-1710 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T27 1707-1710 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 53-62 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 128-143 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T3 168-177 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T4 334-343 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T5 1417-1426 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1747-1758 Phenotype denotes target cell HP:0034280

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 36-39 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 40-45 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 227-230 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 482-485 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 537-540 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T6 542-548 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 759-762 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1002-1005 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1006-1011 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T10 1075-1078 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T11 1155-1158 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 1159-1164 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T13 1294-1297 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T14 1298-1303 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T15 1511-1514 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T16 1707-1710 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 53-62 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 128-143 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T3 168-177 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T4 334-343 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T5 1417-1426 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 53-70 OrganismTaxon denotes influenza A virus 11320
T2 168-185 OrganismTaxon denotes influenza virus A 197911
T3 334-351 OrganismTaxon denotes influenza virus A 197911
T4 1417-1434 OrganismTaxon denotes influenza virus A 197911

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 311-323 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T2 1012-1024 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T3 1085-1097 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T4 1165-1177 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T5 1270-1282 Cell denotes Erythrocytes http://purl.obolibrary.org/obo/CL:0000232

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 207-215 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 311-323 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T5 631-640 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 1012-1024 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T9 1085-1097 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T10 1165-1177 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T11 1270-1282 Body_part denotes Erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T12 1754-1768 Body_part denotes cell membranes http://purl.obolibrary.org/obo/GO_0005886

sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes N-Acetylneuraminyllactosylceramide, GM3-NeuAc, a new influenza A virus receptor which mediates the adsorption-fusion process of viral infection.
T2 145-279 Sentence denotes Binding specificity of influenza virus A/Aichi/2/68 (H3N2) to membrane-associated GM3 with different molecular species of sialic acid.
T3 280-458 Sentence denotes Agglutinates of native chicken erythrocytes caused by influenza virus A/Aichi/2/68 (H3N2) at 4 degrees C were potently fused and lysed at low pH (optimum pH 5.3) at 37 degrees C.
T4 459-711 Sentence denotes Exogenous gangliosides GM3 (Sia alpha 2-3Gal beta 1-4Glc beta 1-ceramide) and GM2 (GalNAc beta 1-4(Sia alpha 2-3)-Gal beta 1-4Glc beta 1-ceramide) were integrated into the membranes of chicken asialoerythrocytes within 5-min incubation at 37 degrees C.
T5 712-972 Sentence denotes We found that the incorporation of ganglioside GM3 containing N-acetylneuraminic acid into asialoerythrocytes restored the biological responsiveness to the virus as established by agglutination at 4 degrees C and fusion and hemolysis at 37 degrees C at pH 5.3.
T6 973-1137 Sentence denotes Biological responsiveness of GM3-NeuAc-erythrocytes to the virus was considerably higher than that of GM3-NeuGc-erythrocytes under the same experimental conditions.
T7 1138-1269 Sentence denotes Treatment of the GM3-NeuAc-erythrocytes with neuraminidase again resulted in the complete abolishment of the response to the virus.
T8 1270-1363 Sentence denotes Erythrocytes containing GM2-NeuAc showed no detectable biological responses toward the virus.
T9 1364-1769 Sentence denotes The above results indicate that the hemagglutinin of influenza virus A/Aichi/2/68 (H3N2) recognizes the sialyloligosaccharide chain of ganglioside GM3 as its receptor which mediates the adsorption and fusion process on the virus entry into the host cells and has more preferential specificity for binding to N-acetylneuraminic acid-containing GM3 than that to N-glycolyl type in the target cell membranes.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes N-Acetylneuraminyllactosylceramide, GM3-NeuAc, a new influenza A virus receptor which mediates the adsorption-fusion process of viral infection.
T2 145-279 Sentence denotes Binding specificity of influenza virus A/Aichi/2/68 (H3N2) to membrane-associated GM3 with different molecular species of sialic acid.
T3 280-972 Sentence denotes Agglutinates of native chicken erythrocytes caused by influenza virus A/Aichi/2/68 (H3N2) at 4 degrees C were potently fused and lysed at low pH (optimum pH 5.3) at 37 degrees C. Exogenous gangliosides GM3 (Sia alpha 2-3Gal beta 1-4Glc beta 1-ceramide) and GM2 (GalNAc beta 1-4(Sia alpha 2-3)-Gal beta 1-4Glc beta 1-ceramide) were integrated into the membranes of chicken asialoerythrocytes within 5-min incubation at 37 degrees C. We found that the incorporation of ganglioside GM3 containing N-acetylneuraminic acid into asialoerythrocytes restored the biological responsiveness to the virus as established by agglutination at 4 degrees C and fusion and hemolysis at 37 degrees C at pH 5.3.
T4 973-1137 Sentence denotes Biological responsiveness of GM3-NeuAc-erythrocytes to the virus was considerably higher than that of GM3-NeuGc-erythrocytes under the same experimental conditions.
T5 1138-1269 Sentence denotes Treatment of the GM3-NeuAc-erythrocytes with neuraminidase again resulted in the complete abolishment of the response to the virus.
T6 1270-1363 Sentence denotes Erythrocytes containing GM2-NeuAc showed no detectable biological responses toward the virus.
T7 1364-1769 Sentence denotes The above results indicate that the hemagglutinin of influenza virus A/Aichi/2/68 (H3N2) recognizes the sialyloligosaccharide chain of ganglioside GM3 as its receptor which mediates the adsorption and fusion process on the virus entry into the host cells and has more preferential specificity for binding to N-acetylneuraminic acid-containing GM3 than that to N-glycolyl type in the target cell membranes.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 36-39 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 40-45 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 227-230 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 482-485 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 537-540 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T6 542-548 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 759-762 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1002-1005 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1006-1011 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T10 1075-1078 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T11 1155-1158 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 1159-1164 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T13 1294-1297 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T14 1298-1303 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T15 1511-1514 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T16 1707-1710 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 53-70 OrganismTaxon denotes influenza A virus 11320
T2 168-185 OrganismTaxon denotes influenza virus A 197911
T3 334-351 OrganismTaxon denotes influenza virus A 197911
T4 1417-1434 OrganismTaxon denotes influenza virus A 197911

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 207-215 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 311-323 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T5 631-640 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 1012-1024 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T9 1085-1097 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T10 1165-1177 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T11 1270-1282 Body_part denotes Erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T12 1754-1768 Body_part denotes cell membranes http://purl.obolibrary.org/obo/GO_0005886

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 311-323 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T2 1012-1024 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T3 1085-1097 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T4 1165-1177 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T5 1270-1282 Cell denotes Erythrocytes http://purl.obolibrary.org/obo/CL:0000232