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PubMed:38366592 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 323-336 Disease denotes malabsorption http://purl.obolibrary.org/obo/MONDO_0020598
T2 914-922 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 323-336 Phenotype denotes malabsorption HP:0002024
T2 914-922 Phenotype denotes diarrhea HP:0002014
T3 1115-1122 Phenotype denotes hypoxia HP:0012418

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 182-189 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 323-336 Phenotype denotes malabsorption HP:0002024
T2 914-922 Phenotype denotes diarrhea HP:0002014
T3 1115-1122 Phenotype denotes hypoxia HP:0012418

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 323-336 Disease denotes malabsorption http://purl.obolibrary.org/obo/MONDO_0020598
T2 914-922 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 72-82 OrganismTaxon denotes Clostridia 186801
T2 106-116 OrganismTaxon denotes microbiota 13613
T3 512-516 OrganismTaxon denotes mice 10088
T4 529-539 OrganismTaxon denotes Clostridia 186801
T5 666-682 OrganismTaxon denotes Escherichia coli 562
T6 693-697 OrganismTaxon denotes mice 10088
T7 747-757 OrganismTaxon denotes Clostridia 186801
T8 808-827 OrganismTaxon denotes Anaerostipes caccae 105841
T9 846-856 OrganismTaxon denotes Clostridia 186801
T10 884-888 OrganismTaxon denotes mice 10088
T11 978-988 OrganismTaxon denotes Clostridia 186801

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 5-8 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T2 102-105 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907
T5 454-457 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T6 1130-1135 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 102-105 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043
T2 1130-1135 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota.
T2 118-275 Sentence denotes Carbohydrate intolerance, commonly linked to the consumption of lactose, fructose, or sorbitol, affects up to 30% of the population in high-income countries.
T3 276-382 Sentence denotes Although sorbitol intolerance is attributed to malabsorption, the underlying mechanism remains unresolved.
T4 383-596 Sentence denotes Here, we show that a history of antibiotic exposure combined with high fat intake triggered long-lasting sorbitol intolerance in mice by reducing Clostridia abundance, which impaired microbial sorbitol catabolism.
T5 597-768 Sentence denotes The restoration of sorbitol catabolism by inoculation with probiotic Escherichia coli protected mice against sorbitol intolerance but did not restore Clostridia abundance.
T6 769-959 Sentence denotes Inoculation with the butyrate producer Anaerostipes caccae restored a normal Clostridia abundance, which protected mice against sorbitol-induced diarrhea even when the probiotic was cleared.
T7 960-1136 Sentence denotes Butyrate restored Clostridia abundance by stimulating epithelial peroxisome proliferator-activated receptor-gamma (PPAR-γ) signaling to restore epithelial hypoxia in the colon.
T8 1137-1323 Sentence denotes Collectively, these mechanistic insights identify microbial sorbitol catabolism as a potential target for approaches for the diagnosis, treatment, and prevention of sorbitol intolerance.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 182-189 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 72-82 OrganismTaxon denotes Clostridia 186801
T2 106-116 OrganismTaxon denotes microbiota 13613
T3 512-516 OrganismTaxon denotes mice 10088
T4 529-539 OrganismTaxon denotes Clostridia 186801
T5 666-682 OrganismTaxon denotes Escherichia coli 562
T6 693-697 OrganismTaxon denotes mice 10088
T7 747-757 OrganismTaxon denotes Clostridia 186801
T8 808-827 OrganismTaxon denotes Anaerostipes caccae 105841
T9 846-856 OrganismTaxon denotes Clostridia 186801
T10 884-888 OrganismTaxon denotes mice 10088
T11 978-988 OrganismTaxon denotes Clostridia 186801

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 102-105 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043
T2 1130-1135 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 5-8 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T2 102-105 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907
T5 454-457 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T6 1130-1135 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155