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PubMed:38154551 JSONTXT

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HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 71-85 Phenotype denotes aa amyloidosis HP:4000041
T2 90-112 Phenotype denotes membranous nephropathy HP:0012578
T3 314-328 Phenotype denotes AA amyloidosis HP:4000041
T4 314-316 Phenotype denotes AA HP:4000041
T5 437-451 Phenotype denotes AA amyloidosis HP:4000041
T6 437-439 Phenotype denotes AA HP:4000041
T7 453-455 Phenotype denotes AA HP:4000041
T8 461-483 Phenotype denotes membranous nephropathy HP:0012578
T9 485-487 Phenotype denotes MN HP:0012578
T10 522-524 Phenotype denotes AA HP:4000041
T11 528-530 Phenotype denotes MN HP:0012578
T12 694-712 Phenotype denotes glomerulosclerosis HP:0000096
T13 717-744 Phenotype denotes tubulointerstitial fibrosis HP:0005576
T14 792-794 Phenotype denotes AA HP:4000041
T15 993-995 Phenotype denotes AA HP:4000041
T16 1008-1010 Phenotype denotes MN HP:0012578
T17 1062-1073 Phenotype denotes proteinuria HP:0000093
T18 1210-1212 Phenotype denotes AA HP:4000041
T19 1225-1227 Phenotype denotes MN HP:0012578
T20 1621-1635 Phenotype denotes AA amyloidosis HP:4000041
T21 1621-1623 Phenotype denotes AA HP:4000041
T22 1791-1805 Phenotype denotes AA amyloidosis HP:4000041
T23 1791-1793 Phenotype denotes AA HP:4000041
T24 1896-1910 Phenotype denotes AA amyloidosis HP:4000041
T25 1896-1898 Phenotype denotes AA HP:4000041
T26 1912-1914 Phenotype denotes AA HP:4000041
T27 1917-1939 Phenotype denotes membranous nephropathy HP:0012578
T28 1941-1943 Phenotype denotes MN HP:0012578
T29 2016-2034 Phenotype denotes glomerulosclerosis HP:0000096
T30 2043-2070 Phenotype denotes tubulointerstitial fibrosis HP:0005576
T31 2498-2500 Phenotype denotes AA HP:4000041
T32 2513-2515 Phenotype denotes MN HP:0012578
T33 2603-2605 Phenotype denotes AA HP:4000041
T34 2618-2620 Phenotype denotes MN HP:0012578
T35 2672-2683 Phenotype denotes proteinuria HP:0000093
T36 2893-2907 Phenotype denotes AA Amyloidosis HP:4000041
T37 2893-2895 Phenotype denotes AA HP:4000041
T38 3199-3213 Phenotype denotes AA amyloidosis HP:4000041
T39 3199-3201 Phenotype denotes AA HP:4000041

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 71-85 Disease denotes aa amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T2 90-112 Disease denotes membranous nephropathy http://purl.obolibrary.org/obo/MONDO_0005376
T3 226-245 Disease denotes glomerular diseases http://purl.obolibrary.org/obo/MONDO_0019722
T4 314-328 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T5 314-316 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T6 437-451 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T7 437-439 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T8 453-455 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T9 461-483 Disease denotes membranous nephropathy http://purl.obolibrary.org/obo/MONDO_0005376
T10 485-487 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T11 522-524 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T12 528-530 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T13 694-712 Disease denotes glomerulosclerosis http://purl.obolibrary.org/obo/MONDO_0000490
T14 792-794 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T15 993-995 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T16 1008-1010 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T17 1062-1073 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T18 1210-1212 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T19 1225-1227 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T20 1448-1455 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T21 1605-1617 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T22 1621-1635 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T23 1621-1623 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T24 1791-1805 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T25 1791-1793 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T26 1896-1910 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T27 1896-1898 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T28 1912-1914 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T29 1917-1939 Disease denotes membranous nephropathy http://purl.obolibrary.org/obo/MONDO_0005376
T30 1941-1943 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T31 2016-2034 Disease denotes glomerulosclerosis http://purl.obolibrary.org/obo/MONDO_0000490
T32 2345-2352 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T33 2498-2500 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T34 2513-2515 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T35 2603-2605 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T36 2618-2620 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T37 2672-2683 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T38 2893-2907 Disease denotes AA Amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T39 2893-2895 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T40 3160-3172 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T41 3199-3213 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T42 3199-3201 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 2580-2587 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 71-85 Phenotype denotes aa amyloidosis HP:4000041
T2 90-112 Phenotype denotes membranous nephropathy HP:0012578
T3 314-328 Phenotype denotes AA amyloidosis HP:4000041
T4 314-316 Phenotype denotes AA HP:4000041
T5 437-451 Phenotype denotes AA amyloidosis HP:4000041
T6 437-439 Phenotype denotes AA HP:4000041
T7 453-455 Phenotype denotes AA HP:4000041
T8 461-483 Phenotype denotes membranous nephropathy HP:0012578
T9 485-487 Phenotype denotes MN HP:0012578
T10 522-524 Phenotype denotes AA HP:4000041
T11 528-530 Phenotype denotes MN HP:0012578
T12 694-712 Phenotype denotes glomerulosclerosis HP:0000096
T13 717-744 Phenotype denotes tubulointerstitial fibrosis HP:0005576
T14 792-794 Phenotype denotes AA HP:4000041
T15 993-995 Phenotype denotes AA HP:4000041
T16 1008-1010 Phenotype denotes MN HP:0012578
T17 1062-1073 Phenotype denotes proteinuria HP:0000093
T18 1210-1212 Phenotype denotes AA HP:4000041
T19 1225-1227 Phenotype denotes MN HP:0012578
T20 1621-1635 Phenotype denotes AA amyloidosis HP:4000041
T21 1621-1623 Phenotype denotes AA HP:4000041
T22 1791-1805 Phenotype denotes AA amyloidosis HP:4000041
T23 1791-1793 Phenotype denotes AA HP:4000041
T24 1896-1910 Phenotype denotes AA amyloidosis HP:4000041
T25 1896-1898 Phenotype denotes AA HP:4000041
T26 1912-1914 Phenotype denotes AA HP:4000041
T27 1917-1939 Phenotype denotes membranous nephropathy HP:0012578
T28 1941-1943 Phenotype denotes MN HP:0012578
T29 2016-2034 Phenotype denotes glomerulosclerosis HP:0000096
T30 2043-2070 Phenotype denotes tubulointerstitial fibrosis HP:0005576
T31 2498-2500 Phenotype denotes AA HP:4000041
T32 2513-2515 Phenotype denotes MN HP:0012578
T33 2603-2605 Phenotype denotes AA HP:4000041
T34 2618-2620 Phenotype denotes MN HP:0012578
T35 2672-2683 Phenotype denotes proteinuria HP:0000093
T36 2893-2907 Phenotype denotes AA Amyloidosis HP:4000041
T37 2893-2895 Phenotype denotes AA HP:4000041
T38 3199-3213 Phenotype denotes AA amyloidosis HP:4000041
T39 3199-3201 Phenotype denotes AA HP:4000041

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 71-85 Disease denotes aa amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T2 90-112 Disease denotes membranous nephropathy http://purl.obolibrary.org/obo/MONDO_0005376
T3 226-245 Disease denotes glomerular diseases http://purl.obolibrary.org/obo/MONDO_0019722
T4 314-328 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T5 314-316 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T6 437-451 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T7 437-439 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T8 453-455 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T9 461-483 Disease denotes membranous nephropathy http://purl.obolibrary.org/obo/MONDO_0005376
T10 485-487 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T11 522-524 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T12 528-530 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T13 694-712 Disease denotes glomerulosclerosis http://purl.obolibrary.org/obo/MONDO_0000490
T14 792-794 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T15 993-995 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T16 1008-1010 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T17 1062-1073 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T18 1210-1212 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T19 1225-1227 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T20 1448-1455 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T21 1605-1617 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T22 1621-1635 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T23 1621-1623 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T24 1791-1805 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T25 1791-1793 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T26 1896-1910 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T27 1896-1898 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T28 1912-1914 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T29 1917-1939 Disease denotes membranous nephropathy http://purl.obolibrary.org/obo/MONDO_0005376
T30 1941-1943 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T31 2016-2034 Disease denotes glomerulosclerosis http://purl.obolibrary.org/obo/MONDO_0000490
T32 2345-2352 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T33 2498-2500 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T34 2513-2515 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T35 2603-2605 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T36 2618-2620 Disease denotes MN http://purl.obolibrary.org/obo/MONDO_0005376
T37 2672-2683 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T38 2893-2907 Disease denotes AA Amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T39 2893-2895 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439
T40 3160-3172 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T41 3199-3213 Disease denotes AA amyloidosis http://purl.obolibrary.org/obo/MONDO_0019439
T42 3199-3201 Disease denotes AA http://purl.obolibrary.org/obo/MONDO_0019439

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 363-368 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T2 499-504 Body_part denotes Urine http://purl.obolibrary.org/obo/UBERON_0001088
T3 2382-2388 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 363-368 Body_part denotes urine http://purl.obolibrary.org/obo/MAT_0000058
T2 499-504 Body_part denotes Urine http://purl.obolibrary.org/obo/MAT_0000058

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes A comparative urinary proteomic and metabolomic analysis between renal aa amyloidosis and membranous nephropathy with clinicopathologic correlations.
T2 150-246 Sentence denotes Urinary omics has become a powerful tool for elucidating pathophysiology of glomerular diseases.
T3 247-329 Sentence denotes However, no urinary omics analysis has been performed yet on renal AA amyloidosis.
T4 330-498 Sentence denotes Here, we performed a comparative urine proteomic and metabolomic analysis between recently diagnosed renal AA amyloidosis (AA) and membranous nephropathy (MN) patients.
T5 499-654 Sentence denotes Urine samples of 22 (8 AA, 8 MN and 6 healthy control) patients were analyzed with nLC-MS/MS and GC/MS for proteomic and metabolomic studies, respectively.
T6 655-752 Sentence denotes Pathological specimens were scored for glomerulosclerosis and tubulointerstitial fibrosis grades.
T7 753-869 Sentence denotes Functional enrichment analysis between AA and control groups showed enrichment in cell adhesion related sub-domains.
T8 870-1017 Sentence denotes Uromodulin (UMOD) was lower, whereas ribonuclease 1 (RNase1) and α-1-microglobulin/bikunin precursor (AMBP) were higher in AA compared to MN group.
T9 1018-1143 Sentence denotes Correlations were demonstrated between UMOD-proteinuria (r = -0.48, p = 0.03) and AMBP-eGFR (r = -0.69, p = 0.003) variables.
T10 1144-1234 Sentence denotes Metabolomic analysis showed myo-inositol and urate were higher in AA compared to MN group.
T11 1235-1344 Sentence denotes A positive correlation was detected between RNase1 and urate independent of eGFR values (r = 0.63, p = 0.01).
T12 1345-1464 Sentence denotes Enrichment in cell adhesion related domains suggested a possible increased urinary shear stress due to amyloid fibrils.
T13 1465-1636 Sentence denotes UMOD, AMBP and myo-inositol were related with tubulointerstitial damage, whereas RNase1 and urate were believed to be related with systemic inflammation in AA amyloidosis.
T14 1637-1650 Sentence denotes SIGNIFICANCE:
T15 1651-1723 Sentence denotes Urinary omics studies have become a standard tool for biomarker studies.
T16 1724-1806 Sentence denotes However, no urinary omics analysis has been performed yet on renal AA amyloidosis.
T17 1807-1975 Sentence denotes Here, we performed a comparative urinary omics analysis between recently diagnosed renal AA amyloidosis (AA), membranous nephropathy (MN) patients and healthy controls.
T18 1976-2156 Sentence denotes Pathological specimens were scored with glomerulosclerosis (G) and tubulointerstitial fibrosis (IF) grades to consolidate the results of the omics studies and correlation analyzes.
T19 2157-2408 Sentence denotes Functional enrichment analysis showed enrichment in cell adhesion related sub-domains due to downregulation of cadherins; which could be related with increased urinary shear stress due to amyloid deposition and disruption of tissue micro-architecture.
T20 2409-2522 Sentence denotes In comparative proteomic analyzes UMOD was lower, whereas RNase1 and AMBP were higher in AA compared to MN group.
T21 2523-2627 Sentence denotes Whereas in metabolomic analyzes; myo-inositol, urate and maltose were higher in AA compared to MN group.
T22 2628-2813 Sentence denotes Correlations were demonstrated between UMOD-proteinuria (r = -0.48, p = 0.03), AMBP-eGFR (r = -0.69, p = 0.003) and between RNase1-Urate independent of eGFR values (r = 0.63, p = 0.01).
T23 2814-2937 Sentence denotes This study is the first comprehensive urinary omics analysis focusing on renal AA Amyloidosis to the best of our knowledge.
T24 2938-3214 Sentence denotes Based on physiologic roles and clinicopathologic correlations of the molecules; UMOD, AMBP and myo-inositol were related with tubulointerstitial damage, whereas RNase1 and urate were believed to be increased with systemic inflammation and endothelial damage in AA amyloidosis.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 2580-2587 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 363-368 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T2 499-504 Body_part denotes Urine http://purl.obolibrary.org/obo/UBERON_0001088
T3 2382-2388 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 363-368 Body_part denotes urine http://purl.obolibrary.org/obo/MAT_0000058
T2 499-504 Body_part denotes Urine http://purl.obolibrary.org/obo/MAT_0000058