PubMed:38049592
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 558-567 | Cell | denotes | (DP) cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T2 | 683-690 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T3 | 845-853 | Cell | denotes | DP cells | http://purl.obolibrary.org/obo/CL:0000809 |
| T4 | 1159-1166 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T5 | 1229-1241 | Cell | denotes | keratinocyte | http://purl.obolibrary.org/obo/CL:0000312 |
| T6 | 1397-1404 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T7 | 1465-1472 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T8 | 1656-1663 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T9 | 1706-1713 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T10 | 1887-1895 | Cell | denotes | DP cells | http://purl.obolibrary.org/obo/CL:0000809 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 124-145 | Disease | denotes | androgenetic alopecia | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T2 | 147-168 | Disease | denotes | Androgenetic alopecia | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T3 | 170-173 | Disease | denotes | AGA | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T4 | 190-211 | Disease | denotes | male pattern baldness | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T5 | 225-234 | Disease | denotes | hair loss | http://purl.obolibrary.org/obo/MONDO_0004907 |
| T6 | 411-414 | Disease | denotes | AGA | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T7 | 702-705 | Disease | denotes | AGA | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T8 | 1785-1794 | Disease | denotes | hair loss | http://purl.obolibrary.org/obo/MONDO_0004907 |
| T9 | 1975-1978 | Disease | denotes | AGA | http://purl.obolibrary.org/obo/MONDO_0005339 |
| T10 | 2077-2086 | Disease | denotes | hair loss | http://purl.obolibrary.org/obo/MONDO_0004907 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 137-145 | Phenotype | denotes | alopecia | HP:0001596 |
| T2 | 160-168 | Phenotype | denotes | alopecia | HP:0001596 |
| T3 | 190-211 | Phenotype | denotes | male pattern baldness | HP:0002292 |
| T4 | 225-234 | Phenotype | denotes | hair loss | HP:0001596 |
| T5 | 1785-1794 | Phenotype | denotes | hair loss | HP:0001596 |
| T6 | 2077-2086 | Phenotype | denotes | hair loss | HP:0001596 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 738-747 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 738-747 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 137-145 | Phenotype | denotes | alopecia | HP:0001596 |
| T2 | 160-168 | Phenotype | denotes | alopecia | HP:0001596 |
| T3 | 190-211 | Phenotype | denotes | male pattern baldness | HP:0002292 |
| T4 | 225-234 | Phenotype | denotes | hair loss | HP:0001596 |
| T5 | 1785-1794 | Phenotype | denotes | hair loss | HP:0001596 |
| T6 | 2077-2086 | Phenotype | denotes | hair loss | HP:0001596 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 558-567 | Cell | denotes | (DP) cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T2 | 683-690 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T3 | 845-853 | Cell | denotes | DP cells | http://purl.obolibrary.org/obo/CL:0000809 |
| T4 | 1159-1166 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T5 | 1229-1241 | Cell | denotes | keratinocyte | http://purl.obolibrary.org/obo/CL:0000312 |
| T6 | 1397-1404 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T7 | 1465-1472 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T8 | 1656-1663 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T9 | 1706-1713 | Cell | denotes | DP cell | http://purl.obolibrary.org/obo/CL:0000809 |
| T10 | 1887-1895 | Cell | denotes | DP cells | http://purl.obolibrary.org/obo/CL:0000809 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 65-72 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T2 | 87-92 | Body_part | denotes | scalp | http://purl.obolibrary.org/obo/UBERON_0000403 |
| T3 | 93-112 | Body_part | denotes | dermal papilla cell | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T4 | 225-229 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/UBERON_0001037|http://purl.obolibrary.org/obo/UBERON_8420000 |
| T6 | 378-385 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T7 | 390-407 | Body_part | denotes | occipital regions | http://purl.obolibrary.org/obo/UBERON_0005902 |
| T8 | 460-467 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T9 | 468-482 | Body_part | denotes | hair follicles | http://purl.obolibrary.org/obo/UBERON_0002073 |
| T10 | 521-528 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T11 | 543-557 | Body_part | denotes | dermal papilla | http://purl.obolibrary.org/obo/UBERON_0000412|http://purl.obolibrary.org/obo/UBERON_0001763|http://purl.obolibrary.org/obo/UBERON_0011803|http://purl.obolibrary.org/obo/UBERON_2001995 |
| T15 | 559-561 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T16 | 655-662 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T17 | 677-682 | Body_part | denotes | scalp | http://purl.obolibrary.org/obo/UBERON_0000403 |
| T18 | 683-685 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T19 | 845-847 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T20 | 1151-1158 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T21 | 1159-1161 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T22 | 1188-1201 | Body_part | denotes | hair follicle | http://purl.obolibrary.org/obo/UBERON_0002073 |
| T23 | 1229-1241 | Body_part | denotes | keratinocyte | http://purl.obolibrary.org/obo/CL_0000312 |
| T24 | 1389-1396 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T25 | 1397-1399 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T26 | 1465-1467 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T27 | 1596-1598 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T28 | 1648-1655 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T29 | 1656-1658 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T30 | 1684-1691 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T31 | 1706-1708 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T32 | 1785-1789 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/UBERON_0001037|http://purl.obolibrary.org/obo/UBERON_8420000 |
| T34 | 1865-1872 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T35 | 1887-1889 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T36 | 2077-2081 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/UBERON_0001037|http://purl.obolibrary.org/obo/UBERON_8420000 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 190-194 | Body_part | denotes | male | http://purl.obolibrary.org/obo/MAT_0000029 |
| T2 | 225-229 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T3 | 468-472 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T4 | 1188-1192 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T5 | 1785-1789 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T6 | 2077-2081 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-146 | Sentence | denotes | Establishment and characterization of matched immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia. |
| T2 | 147-288 | Sentence | denotes | Androgenetic alopecia (AGA), also known as male pattern baldness, is a common hair loss condition influenced by genetic and hormonal factors. |
| T3 | 289-424 | Sentence | denotes | Variations in gene expression and androgen responsiveness have been observed between the frontal and occipital regions of AGA patients. |
| T4 | 425-498 | Sentence | denotes | However, obtaining and cultivating frontal hair follicles is challenging. |
| T5 | 499-597 | Sentence | denotes | Therefore, no matched frontal and occipital dermal papilla (DP) cell lines have been reported yet. |
| T6 | 598-715 | Sentence | denotes | This study aimed to establish matched immortalized human frontal and occipital scalp DP cell lines from AGA patients. |
| T7 | 716-854 | Sentence | denotes | Simian virus 40 large T antigen (SV40T-Ag) and human telomerase reverse transcriptase (hTERT) were introduced into primary human DP cells. |
| T8 | 855-1018 | Sentence | denotes | The obtained cell lines were characterized by assessing their gene expression patterns, androgen receptor (AR) levels, and the presence of 5-alpha reductase (5αR). |
| T9 | 1019-1118 | Sentence | denotes | Additionally, we examined their response to dihydrotestosterone (DHT) and evaluated cell viability. |
| T10 | 1119-1280 | Sentence | denotes | The conditioned medium from the frontal DP cell line inhibited human hair follicle growth, leading to reduced keratinocyte proliferation and increased apoptosis. |
| T11 | 1281-1563 | Sentence | denotes | Furthermore, when the cells were cultured in a 3D environment mimicking in vivo conditions, the 3D cultured frontal DP cell line exhibited weaker sphere aggregation than the occipital DP cell line due to the increased expression of matrix metalloproteinase 1 (MMP1), MMP3, and MMP9. |
| T12 | 1564-1669 | Sentence | denotes | Additionally, the expression of DP signature genes was inhibited in the 3D cultured frontal DP cell line. |
| T13 | 1670-1795 | Sentence | denotes | These matched frontal and occipital DP cell lines hold significant potential as valuable resources for research on hair loss. |
| T14 | 1796-1979 | Sentence | denotes | Their establishment allows us to investigate the differences between frontal and occipital DP cells, contributing to a better understanding of the molecular mechanisms underlying AGA. |
| T15 | 1980-2098 | Sentence | denotes | Furthermore, these cell lines may be valuable for developing targeted therapeutic approaches for hair loss conditions. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 738-747 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 738-747 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 124-145 | Disease | denotes | androgenetic alopecia | MONDO:0005339 |
| T2 | 147-168 | Disease | denotes | Androgenetic alopecia | MONDO:0005339 |
| T3 | 170-173 | Disease | denotes | AGA | MONDO:0005339 |
| T4 | 190-211 | Disease | denotes | male pattern baldness | MONDO:0005339 |
| T5 | 225-234 | Disease | denotes | hair loss | MONDO:0004907 |
| T6 | 411-414 | Disease | denotes | AGA | MONDO:0005339 |
| T7 | 702-705 | Disease | denotes | AGA | MONDO:0005339 |
| T8 | 1785-1794 | Disease | denotes | hair loss | MONDO:0004907 |
| T9 | 1975-1978 | Disease | denotes | AGA | MONDO:0005339 |
| T10 | 2077-2086 | Disease | denotes | hair loss | MONDO:0004907 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 59-64 | OrganismTaxon | denotes | human | 9606 |
| T2 | 649-654 | OrganismTaxon | denotes | human | 9606 |
| T3 | 716-731 | OrganismTaxon | denotes | Simian virus 40 | 1891767 |
| T4 | 763-768 | OrganismTaxon | denotes | human | 9606 |
| T5 | 839-844 | OrganismTaxon | denotes | human | 9606 |
| T6 | 1182-1187 | OrganismTaxon | denotes | human | 9606 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 59-64 | OrganismTaxon | denotes | human | 9606 |
| T2 | 649-654 | OrganismTaxon | denotes | human | 9606 |
| T3 | 716-731 | OrganismTaxon | denotes | Simian virus 40 | 1891767 |
| T4 | 763-768 | OrganismTaxon | denotes | human | 9606 |
| T5 | 839-844 | OrganismTaxon | denotes | human | 9606 |
| T6 | 1182-1187 | OrganismTaxon | denotes | human | 9606 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 190-194 | Body_part | denotes | male | http://purl.obolibrary.org/obo/MAT_0000029 |
| T2 | 225-229 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T3 | 468-472 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T4 | 1188-1192 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T5 | 1785-1789 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
| T6 | 2077-2081 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/MAT_0000160 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 65-72 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T2 | 87-92 | Body_part | denotes | scalp | http://purl.obolibrary.org/obo/UBERON_0000403 |
| T3 | 93-112 | Body_part | denotes | dermal papilla cell | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T4 | 225-229 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/UBERON_0001037|http://purl.obolibrary.org/obo/UBERON_8420000 |
| T6 | 378-385 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T7 | 390-407 | Body_part | denotes | occipital regions | http://purl.obolibrary.org/obo/UBERON_0005902 |
| T8 | 460-467 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T9 | 468-482 | Body_part | denotes | hair follicles | http://purl.obolibrary.org/obo/UBERON_0002073 |
| T10 | 521-528 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T11 | 543-557 | Body_part | denotes | dermal papilla | http://purl.obolibrary.org/obo/UBERON_0000412|http://purl.obolibrary.org/obo/UBERON_0001763|http://purl.obolibrary.org/obo/UBERON_0011803|http://purl.obolibrary.org/obo/UBERON_2001995 |
| T15 | 559-561 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T16 | 655-662 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T17 | 677-682 | Body_part | denotes | scalp | http://purl.obolibrary.org/obo/UBERON_0000403 |
| T18 | 683-685 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T19 | 845-847 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T20 | 1151-1158 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T21 | 1159-1161 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T22 | 1188-1201 | Body_part | denotes | hair follicle | http://purl.obolibrary.org/obo/UBERON_0002073 |
| T23 | 1229-1241 | Body_part | denotes | keratinocyte | http://purl.obolibrary.org/obo/CL_0000312 |
| T24 | 1389-1396 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T25 | 1397-1399 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T26 | 1465-1467 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T27 | 1596-1598 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T28 | 1648-1655 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T29 | 1656-1658 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T30 | 1684-1691 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T31 | 1706-1708 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T32 | 1785-1789 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/UBERON_0001037|http://purl.obolibrary.org/obo/UBERON_8420000 |
| T34 | 1865-1872 | Body_part | denotes | frontal | http://purl.obolibrary.org/obo/UBERON_0000209 |
| T35 | 1887-1889 | Body_part | denotes | DP | http://purl.obolibrary.org/obo/UBERON_0000412 |
| T36 | 2077-2081 | Body_part | denotes | hair | http://purl.obolibrary.org/obo/UBERON_0001037|http://purl.obolibrary.org/obo/UBERON_8420000 |